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Browsing by Subject "Drug Delivery Systems"

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    • Article  

      Caspase-independent pathways of programmed cell death: The unraveling of new targets of cancer therapy? 

      Constantinou, Constantina; Papas, Konstantinos A.; Constantinou, Andreas I. (2009)
      In the past few years, accumulating evidence in the literature supports the existence of pathways of caspase-independent programmed cell death (CI-PCD). These pathways are likely to be acting as 'death backup systems' that ...

    • Article  

      Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model 

      Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (2013)
      Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...

    • Article  

      Combining two strategies to improve perfusion and drug delivery in solid tumors 

      Stylianopoulos, T.; Jain, R. K. (2013)
      Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a ...

    • Article  

      Delivering nanomedicine to solid tumors 

      Jain, R. K.; Stylianopoulos, T. (2010)
      Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for using nanoparticles to treat ...

    • Article  

      Delivery of molecular and nanoscale medicine to tumors: Transport barriers and strategies 

      Chauhan, V. P.; Stylianopoulos, T.; Boucher, Y.; Jain, R. K. (2011)
      Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by nonuniform drug delivery via blood vessels, inhomogeneous drug transport ...

    • Article  

      Design considerations for nanotherapeutics in oncology 

      Stylianopoulos, T.; Jain, R. K. (2015)
      Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing the adverse effects of chemotherapeutic agents, but improvements in overall survival are modest. This is in large part due to the ...

    • Article  

      Drug delivery innovations for enhancing the anticancer potential of vitamin e isoforms and their derivatives 

      Neophytou, Christiana M.; Constantinou, Andreas I. (2015)
      Vitamin E isoforms have been extensively studied for their anticancer properties. Novel drug delivery systems (DDS) that include liposomes, nanoparticles, and micelles are actively being developed to improve Vitamin E ...

    • Article  

      Multiresponsive polymer conetworks capable of responding to changes in pH, temperature, and magnetic field: Synthesis, characterization, and evaluation of their ability for controlled uptake and release of solutes 

      Papaphilippou, P.; Christodoulou, M.; Marinica, O. M.; Taculescu, A.; Vekas, L.; Chrissafis, K.; Krasia-Christoforou, T. (2012)
      This study deals with the preparation of novel multiresponsive (magnetoresponsive, thermoresponsive and pH-responsive) nanocomposite conetworks consisting of oleic acid-coated magnetite nanoparticles (OA•Fe 3O 4), ...

    • Article  

      Multistage nanoparticle delivery system for deep penetration into tumor tissue 

      Wong, C.; Stylianopoulos, T.; Cui, J.; Martin, J.; Chauhan, V. P.; Jiang, W.; Popovic, Z.; Jain, R. K.; Bawendi, M. G.; Fukumura, D. (2011)
      Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...

    • Article  

      The role of mechanical forces in tumor growth and therapy 

      Jain, R. K.; Martin, J. D.; Stylianopoulos, T. (2014)
      Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...

    • Article  

      Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy 

      Mpekris, F.; Papageorgis, P.; Polydorou, C.; Voutouri, C.; Kalli, M.; Pirentis, A. P.; Stylianopoulos, T. (2017)
      Targeting the rich extracellular matrix of desmoplastic tumors has been successfully shown to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical forces, improving tumor perfusion and chemotherapy. ...

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