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Browsing by Subject "Drug effect"

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    • Article  

      Are the effects of tamoxifen on the serum lipid profile modified by apolipoprotein E phenotypes? 

      Liberopoulos, E. N.; Karabina, S. A.; Tselepis, A.; Bairaktari, Eleni Th; Nikolaides, C.; Pavlidis, Nicholas; Elisaf, Moses S. (2002)
      Background: Tamoxifen has favorable effects on the serum lipid profile. It has been suggested that the apolipoprotein (Apo) E phenotype can influence serum lipid parameters; the ApoE allele 4 (ApoE4) is associated with ...

    • Article  

      The beneficial effect of tamoxifen on serum lipoprotein-a levels: An additional anti-atherogenic property 

      Elisaf, Moses S.; Bairaktari, Eleni Th; Nikolaides, C.; Fountzilas, George; Tzallas, C. S.; Siamopoulos, K. C.; Tsolas, O.; Pavlidis, Nicholas (1996)
      It has recently been suggested that increased lipoprotein (a) levels are an independent risk factor for coronary heart disease. It has also been reported that tamoxifen can induce changes in blood lipid values. In this ...

    • Article  

      Commentary on pravastatin and cancer: Need for individual patient data meta-analyses 

      Bonovas, Stefanos; Nikolopoulos, Georgios K.; Sitaras, N. M. (2010)

    • Article  

      Effect of letrozole on the lipid profile in postmenopausal women with breast cancer 

      Elisaf, Moses S.; Bairaktari, Eleni Th; Nikolaides, C.; Kakaidi, B.; Tzallas, C. S.; Katsaraki, A.; Pavlidis, Nicholas (2001)
      Hormonal therapy plays a central role in the overall treatment of breast cancer. Aromatase inhibitors can inhibit the aromatase enzyme system resulting in a reduction of oestrogens. Letrozole is a non-steroidal aromatase ...

    • Article  

      The effect of tamoxifen therapy on serum apolipoprotein A-I level is modified by the apolipoprotein E phenotype 

      Liberopoulos, E. N.; Pavlidis, Nicholas; Elisaf, Moses S. (2001)

    • Article  

      Glufosfamide administered using a 1-hour infusion given as first-line treatment for advanced pancreatic cancer. A phase II trial of the EORTC-new drug development group 

      Briassoulis, E. Ch; Pavlidis, Nicholas; Terret, C.; Bauer, J.; Fiedler, W.; Schöffski, P.; Raoul, J. L.; Hess, D.; Selvais, R.; Lacombe, D.; Bachmann, P.; Fumoleau, P. (2003)
      The activity of glufosfamide (β-D-glucopyranosyl-N,N′ -di-(2-chloroethyl)-phosphoric acid diamide) against pancreatic cancer was investigated in a multicentre, phase II clinical study. Chemotherapy-naïve patients with ...

    • Article  

      Laboratory Assessment of the Anticoagulant Activity of Dabigatran 

      Kyriakou, Elias; Ikonomidis, Ignatios; Stylos, D.; Bonovas, Stefanos; Papadakis, I.; Nikolopoulos, Georgios K.; Kokoris, Styliani; Kalantzis, Dimitrios; Economopoulou, Christine; Kopterides, Petros; Lekakis, John; Tsantes, Argirio E. (2015)
      Background: Our aim was to identify laboratory assays in order to assess the anticoagulant effects of dabigatran etexilate (DE). Methods: Twenty patients with nonvalvular atrial fibrillation treated on DE (110 mg per os ...

    • Article  

      Paclitaxel-carboplatin combination chemotherapy in advanced breast cancer: Accumulating evidence for synergy, efficacy, and safety 

      Pentheroudakis, George; Razi, E. D.; Athanasiades, A.; Pavlidis, Nicholas; Fountzilas, George (2006)
      Patients with metastatic breast cancer receive multiple lines of cytotoxic chemotherapy, with taxane and anthracycline-based regimens being the most active. Anthracyclines carry the risk of significant cardiotoxicity at ...

    • Article  

      Phase II study of docetaxel-vinorelbine in platinum-resistant, paclitaxel-pretreated ovarian cancer 

      Aravantinos, Gerasimos; Bafaloukos, Dimitrios; Fountzilas, George; Christodoulou, C.; Papadimitriou, C.; Pavlidis, Nicholas; Kalofonos, H. P.; Gogas, H.; Kosmidis, Paraskevas A.; Dimopoulos, M. A. (2003)
      Background: This multicenter, prospective phase II study evaluated the safety and efficacy of the combination of docetaxel and vinorelbine in patients with platinum-resistant, paclitaxel-pretreated recurrent ovarian cancer. ...

    • Article  

      Prevention of anemia in patients with solid tumors receiving platinum-based chemotherapy by recombinant human erythropoietin (rHuEPO): A prospective, open label, randomized trial by the hellenic cooperative oncology group 

      Bamias, A. T.; Aravantinos, Gerasimos; Kalofonos, H. P.; Timotheadou, N.; Siafaka, V.; Vlahou, I.; Janinis, D.; Pectasides, Dimitrios; Pavlidis, Nicholas; Fountzilas, George (2003)
      Objectives: Platinum compounds are commonly associated with significant anemia. Erythropoietin administration has been found effective in correcting anemia in patients with solid tumors receiving chemotherapy. We conducted ...

    • Article  

      Prognostic significance of RACGAP1 mRNA expression in high-risk early breast cancer: A study in primary tumors of breast cancer patients participating in a randomized Hellenic Cooperative Oncology Group trial 

      Pliarchopoulou, K.; Kalogeras, K. T.; Kronenwett, R.; Wirtz, R. M.; Eleftheraki, A. G.; Batistatou, Anna; Bobos, M.; Soupos, N.; Polychronidou, G.; Gogas, H.; Samantas, E.; Christodoulou, C.; Makatsoris, T.; Pavlidis, Nicholas; Pectasides, Dimitrios; Fountzilas, George (2013)
      Purpose: RACGAP1 is a Rac GTPase-activating protein involved in cell growth regulation, cell transformation and metastasis. The aim of the present study was to explore the prognostic and/or predictive significance of RACGAP1 ...

    • Article  

      Receptor for advanced glycation end products in bacterial infection: Is there a role for immune modulation of receptor for advanced glycation end products in the treatment of sepsis? 

      Christaki, Eirini; Lazaridis, Nikolaos; Opal, Steven M. (2012)
      Purpose of review: Sepsis is still associated with excess morbidity and mortality worldwide, despite significant advances in critical care medicine. A novel approach is needed in the treatment of sepsis, one that will aim ...

    • Article  

      Specific antibody to Cryptococcus neoformans glucurunoxylomannan antagonizes antifungal drug action against cryptococcal biofilms in vitro 

      Martinez, Luis R.; Christaki, Eirini; Casadevall, Arturo (2006)
      The fungus Cryptococcus neoformans possesses a polysaccharide capsule and can form biofilms on medical devices. We investigated the efficacy that the combination of a specific antibody to the capsular polysaccharide and ...

    • Article  

      Vinblastine and interferon-gamma combination with and without 13-cis retinoic acid for patients with advanced renal cell carcinoma: Results of two phase II clinical trials 

      Bacoyiannis, Charalambos; Dimopoulos, M. A.; Kalofonos, H. P.; Nikolaides, C.; Aravantinos, Gerasimos; Bafaloukos, Dimitrios; Samelis, G.; Onienaoum, A.; Kiamouris, Ch; Skarlos, Dimosthenis V.; Pavlidis, Nicholas; Triantafillidis, A.; Kosmidis, Paraskevas A. (2002)
      Background: The aim of this study is firstly to determine the response rates and toxicity of two regimens containing vinblastine (VBL) in combination with interferon-gamma (IFN-γ) in the treatment of patients with advanced ...

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