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Browsing by Subject "Drug megadose"

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    • Article  

      Cancer, fertility and pregnancy: ESMO Clinical Recommendations for diagnosis, treatment and follow-up 

      Pentheroudakis, George; Pavlidis, Nicholas; Castiglione, M. (2009)

    • Article  

      The diagnostic and therapeutic management of leptomeningeal carcinomatosis 

      Pavlidis, Nicholas (2004)

    • Article  

      Effects of hormonal treatment on lipids in patients with cancer 

      Filippatos, T. D.; Liberopoulos, E. N.; Pavlidis, Nicholas; Elisaf, Moses S.; Mikhailidis, Dimitri P. (2009)
      Patients with malignant disease may need hormonal therapy as primary or adjuvant treatment or for palliation. Oestrogens usually decrease serum levels of total cholesterol (TC) and low density lipoprotein cholesterol ...

    • Article  

      Forty years experience of treating cancer of unknown primary 

      Pavlidis, Nicholas (2007)
      Cancer of unknown primary site (CUP) is not a rare tumour. It accounts as the seventh to eighth most frequently diagnosed cancer in a general medical oncology service. Since CUP is not a homogeneous disease and it consists ...

    • Article  

      High‐dose epirubicin and r‐met‐hu G‐CSF (Filgrastim) in the treatment of patients with advanced breast cancer: A hellenic cooperative oncology group study 

      Fountzilas, George; Skarlos, Dimosthenis V.; Katsohis, C.; Pavlidis, Nicholas; Giannakakis, T.; Bafaloukos, Dimitrios; Fahantidis, E.; Klouvas, G. D.; Beer, M.; Kosmidis, Paraskevas A. (1995)
      The delivery of high‐dose epirubicin in patients with advanced breast cancer usually entails serious myelotoxicity and frequent treatment delays. Concurrent administration of G‐CSF probably allows the administration of ...

    • Article  

      Immunomodulatory therapy for sepsis: An update 

      Christaki, Eirini; Anyfanti, Panagiota; Opal, Steven M. (2011)
      Currently the treatment mainstay of sepsis is early and appropriate antibiotic therapy, accompanied by aggressive fluid administration, the use of vasopressors when needed and the prompt initiation of measures to support ...

    • Article  

      Intensified bimonthly cisplatin with bolus 5-fluorouracil, continuous 5-fluorouracil and high-dose leucovorin (LV5FU2) in patients with advanced gastrointestinal carcinomas: A phase I dose-finding and pharmacokinetic study 

      Bamias, A. T.; Syrigos, K.; Fountzilas, George; Tzamakou, E.; Soulti, K.; Karavasilis, V.; Alamanos, Y. P.; Christodoulou, C.; Pavlidis, Nicholas (2004)
      5-Fluorouracil (5FU) and cisplatin are commonly used in the treatment of gastric cancer. Continuous 5FU appears to be more effective and less toxic than bolus administration, while increasing the dose intensity of cisplatin ...

    • Article  

      Juvenile cancer: Improving care for adolescents and young adults within the frame of medical oncology 

      Pentheroudakis, George; Pavlidis, Nicholas (2005)
      Despite unique tumour epidemiology, a higher cancer incidence and modest survival improvement compared to paediatric patients, adolescents and young adults aged 15-30 have not been considered as a separate, 'special' group ...

    • Article  

      Management of Gradenigo syndrome in a child 

      Iliadis, Charalambos; Wozniak, Greta; Vlychou, M.; Barkatsa, V.; Sotirakou, S.; Kunz, A. (2010)
      Background: Gradenigo syndrome is a rare presentation of acute petrositis characterized by medial otitis, retro- orbital pain and abducens nerve palsy (CN VI palsy) affecting the lateral rectus muscle (CN VI palsy), due ...

    • Article  

      Paclitaxel-carboplatin combination chemotherapy in advanced breast cancer: Accumulating evidence for synergy, efficacy, and safety 

      Pentheroudakis, George; Razi, E. D.; Athanasiades, A.; Pavlidis, Nicholas; Fountzilas, George (2006)
      Patients with metastatic breast cancer receive multiple lines of cytotoxic chemotherapy, with taxane and anthracycline-based regimens being the most active. Anthracyclines carry the risk of significant cardiotoxicity at ...

    • Article  

      Postoperative radiation and concomitant bolus fluorouracil with or without additional chemotherapy with fluorouracil and high-dose leucovorin in patients with high-risk rectal cancer: A randomized phase III study conducted by the hellenic cooperative oncology group 

      Fountzilas, George; Zisiadis, A.; Dafni, U.; Konstantaras, C.; Hatzitheoharis, G.; Liaros, A.; Athanassiou, E.; Dombros, N.; Dervenis, C.; Basdanis, G.; Gamvros, O.; Souparis, A.; Briassoulis, E. Ch; Samantas, E.; Kappas, A. M.; Kosmidis, Paraskevas A.; Skarlos, Dimosthenis V.; Pavlidis, Nicholas (1999)
      Background: Randomized studies have shown that postoperative chemotherapy with or without radiation therapy (RT) improved local control and survival of patients with stages II or III rectal cancer. However, the optimal ...

    • Article  

      A randomized trial to compare the efficacy and safety of antiemetic treatment with ondansetron and ondansetron zydis in patients with breast cancer treated with high-dose epirubicin 

      Pectasides, Dimitrios; Dafni, U.; Aravantinos, Gerasimos; Timotheadou, E.; Skarlos, Dimosthenis V.; Pavlidis, Nicholas; Gaglia, A.; Kalofonos, H. P.; Fountzilas, George (2007)
      Objective: The objective of this study was to compare the efficacy of a disintegrating tablet of ondansetron (ODT) and the conventional tablet formulation of ondansetron (OT) in controlling nausea and vomiting in breast ...

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