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Browsing by Subject "Enzyme inhibition"

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    • Article  

      Antivirals used for influenza chemoprophylaxis 

      Tsiodras, Sotirios; Nikolopoulos, Georgios K.; Bonovas, Stefanos (2012)
      Current data about the role of adamantanes and neuraminidase inhibitors (NIs) in the chemoprophylaxis against influenza viruses were reviewed. We found significant evidence favouring the role of NIs in the chemoprophylaxis ...

    • Article  

      Application of abductive ILP to learning metabolic network inhibition from temporal data 

      Tamaddoni-Nezhad, A.; Chaleil, R.; Kakas, Antonis C.; Muggleton, S. (2006)
      In this paper we use a logic-based representation and a combination of Abduction and Induction to model inhibition in metabolic networks. In general, the integration of abduction and induction is required when the following ...

    • Article  

      Computational predictions of the tensile properties of electrospun fibre meshes: Effect of fibre diameter and fibre orientation 

      Barocas, V. Η; Stylianopoulos, T.; Bashur, C. A.; Goldstein, A. S.; Guelcher, S. A. (2008)
      The mechanical properties of biomaterial scaffolds are crucial for their efficacy in tissue engineering and regenerative medicine. At the microscopic scale, the scaffold must be sufficiently rigid to support cell adhesion, ...

    • Conference Object  

      Modelling inhibition in metabolic pathways through abduction and induction 

      Tamaddoni-Nezhad, A.; Kakas, Antonis C.; Muggleton, S.; Pazos, F. (2004)
      In this paper, we study how a logical form of scientific modelling that integrates together abduction and induction can be used to understand the functional class of unknown enzymes or inhibitors. We show how we can model, ...

    • Article  

      The role of mechanical forces in tumor growth and therapy 

      Jain, R. K.; Martin, J. D.; Stylianopoulos, T. (2014)
      Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...

    • Article  

      Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy 

      Mpekris, F.; Papageorgis, P.; Polydorou, C.; Voutouri, C.; Kalli, M.; Pirentis, A. P.; Stylianopoulos, T. (2017)
      Targeting the rich extracellular matrix of desmoplastic tumors has been successfully shown to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical forces, improving tumor perfusion and chemotherapy. ...

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