• Book Chapter  

      Breast Cancer Epigenetics 

      Pitta, Chara A.; Constantinou, Andreas I. (Elsevier Inc., 2015)
      The molecular mechanisms underlying the development and progression of breast cancer are far from being understood. It is obvious that the initiation of breast cancer as well as its transition toward distinct breast cancer ...
    • Article  

      Cancer of unknown primary site: 20 questions to be answered 

      Pavlidis, Nicholas; Pentheroudakis, George (2010)
      Cancer of unknown primary (CUP) is a common, well-recognized and heterogeneous clinical syndrome. Patients with CUP present with metastatic disease in the absence of an identifiable primary tumour despite a diagnostic ...
    • Article  

      Cross-talk among epigenetic modifications: Lessons from histone arginine methylation 

      Molina-Serrano, D.; Schiza, V.; Kirmizis, Antonis (2013)
      Epigenetic modifications, including those occurring on DNA and on histone proteins, control gene expression by establishing and maintaining different chromatin states. In recent years, it has become apparent that epigenetic ...
    • Article  

      Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway 

      Pavlou, Demos; Kirmizis, Antonis (2016)
      Protein N-terminal acetylation is an abundant post-translational modification in eukaryotes implicated in various fundamental cellular and biochemical processes. This modification is catalysed by evolutionarily conserved ...
    • Doctoral Thesis  Open Access

      Reversal of epigenetic ER-β silencing restores sensitivity to tamoxifen in breast cancer cells 

      Pitta, Chara A. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2013-12)
      Όγκοι μαστού οι οποίοι εκφράζουν τους υποδοχείς οιστρογόνου ER-α και ER-β ανταποκρίνονται αποτελεσματικά στις θεραπευτικές και χημειοπροστατευτικές θεραπείες με τη χρήση επιλεκτικών για τους υποδοχείς οιστρογόνου ρυθμιστικών ...
    • Article  

      Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance 

      Pitta, Chara A.; Papageorgis, P.; Charalambous, Christina; Constantinou, Andreas I. (2013)
      The purpose of this work is to determine the molecular mechanisms underlying tamoxifen resistance. We show here that ER-β is epigenetically silenced in a cell line with acquired tamoxifen resistance (MCF-7/TAM-R) and this ...
    • Doctoral Thesis  Open Access

      The role of histone N-terminal acetyltransferase Naa40 in gene expression and colorectal cancer cell death 

      Pavlou, Demetria P. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2016-04)
      Η αμινο-τελική ακετυλίωση (Nτ-ακετυλίωση) των πρωτεϊνών αποτελεί μία από τις συνηθέστερες τροποποιήσεις που παρουσιάζονται στο 80-90% των κυτταροπλασματικών, ευκαρυωτικών πρωτεϊνών. Αυτή η τροποποίηση έχει αναδειχθεί ως ...