Browsing by Subject "Erinaceidae"
Now showing items 1-5 of 5
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Article
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
(2012)The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...
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Article
Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch
(2001)Groucho (Gro) is the founding member of a family of transcriptional co-repressors that are recruited by a number of different transcription factors. Drosophila has a single gro gene, whose loss of function affects processes ...
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Article
Haploinsufficiency of the miR-873/miR-876 microRNA cluster is associated with craniofacial abnormalities
(2015)MicroRNA haploinsufficiency has been associated with developmental defects in only a limited number of cases. Here we report a de novo genomic microdeletion that includes the LINGO2 gene as well as two microRNA genes, ...
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Article
Hedgehog restricts its expression domain in the Drosophila wing
(2007)The stable subdivision of Drosophila limbs into anterior and posterior compartments is a consequence of asymmetrical signalling by Hedgehog (Hh), from the posterior to anterior cells. The activity of the homeodomain protein ...
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Article
Signaling mechanisms controlling cell fate and embryonic patterning
(2012)During development, signaling pathways specify cell fates by activating transcriptional programs in response to extracellular signals. Extensive studies in the past 30 years have revealed that surprisingly fewpathways exist ...