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Browsing by Subject "Erlotinib"

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    • Article  

      Cancer and pregnancy: What should we know about the management with systemic treatment of pregnant women with cancer? 

      Pavlidis, Nicholas (2011)
      The incidence of cancer during pregnancy is a rare phenomenon and is estimated to occur in 1:1000 pregnancies. This co-existence is likely to rise since the delay of childbearing to the later reproductive age is nowadays ...

    • Article  

      Cancer of unknown primary site: 20 questions to be answered 

      Pavlidis, Nicholas; Pentheroudakis, George (2010)
      Cancer of unknown primary (CUP) is a common, well-recognized and heterogeneous clinical syndrome. Patients with CUP present with metastatic disease in the absence of an identifiable primary tumour despite a diagnostic ...

    • Article  

      Carcinoma of unknown primary (CUP) 

      Pavlidis, Nicholas; Fizazi, K. (2009)
      Carcinoma of unknown primary (CUP) is one of the 10 most frequent cancers worldwide. It constitutes 3-5% of all human malignancies. Patients with CUP present with metastases without an established primary site. CUP manifests ...

    • Article  

      Disseminated intravascular coagulation (DIC) and non-small cell lung cancer (NSCLC): Report of a case and review of the literature 

      Voulgaris, E.; Pentheroudakis, George; Vassou, A.; Pavlidis, Nicholas (2009)
      The clinical manifestation of disseminated intravascular coagulation (DIC) as paraneoplastic phenomenon is common in patients with lung cancer (especially in those with non small cell lung cancer).Surprisingly, only few ...

    • Article  

      Forty years experience of treating cancer of unknown primary 

      Pavlidis, Nicholas (2007)
      Cancer of unknown primary site (CUP) is not a rare tumour. It accounts as the seventh to eighth most frequently diagnosed cancer in a general medical oncology service. Since CUP is not a homogeneous disease and it consists ...

    • Article  

      Lung cancer in the pregnant woman: To treat or not to treat, that is the question 

      Jr, H. A. Azim; Peccatori, Fedro A.; Pavlidis, Nicholas (2010)
      Lung cancer in pregnancy is a rare situation; however, it is increasingly reported in the past two decades. The association might be more encountered in the coming years due to the rising trends of cigarette smoking among ...

    • Article  

      Molecular assignment of tissue of origin in cancer of unknown primary may not predict response to therapy or outcome: A systematic literature review 

      Pentheroudakis, George; Greco, F. A.; Pavlidis, Nicholas (2009)
      Background: Gene expression profiling platforms were recently shown to accurately assign cancer of unknown primary (CUP) to a primary tissue of origin, with unknown impact on patient outcome. We examined chemotherapy ...

    • Article  

      Neuroendocrine carcinoma of unknown primary: A systematic review of the literature and a comparative study with other neuroendocrine tumors 

      Stoyianni, A.; Pentheroudakis, George; Pavlidis, Nicholas (2011)
      Introduction: Neuroendocrine carcinomas of unknown primary (NCUP) represent a specific subset with relatively favorable prognosis. Data on biology, management and outcome of NCUP patients have not been systematically ...

    • Article  

      Optimal therapeutic management of patients with distinct clinicopathological cancer of unknown primary subsets 

      Pavlidis, Nicholas (2012)
      Cancer of unknown primary sites (CUP) is a compilation of various malignant entities-the majority of which behave aggressively and carry poor prognosis. CUP is classified into two different clinicopathological groups: the ...

    • Article  

      Perspectives for targeted therapies in cancer of unknown primary site 

      Pentheroudakis, George; Pavlidis, Nicholas (2006)
      Cancer of unknown primary site (CUP) ranks as the fourth most common cause of cancer deaths. Regression of the primary, early development of systemic metastases and resistance to therapy are hallmarks of this heterogeneous ...

    • Article  

      Systemic treatment-induced gastrointestinal toxicity: Incidence, clinical presentation and management 

      Boussios, Stergios; Pentheroudakis, George; Katsanos, K.; Pavlidis, Nicholas (2012)
      The toxicity of cancer chemotherapy is among the most important factors limiting its use. Clear delineation and communication of benefits and risks is an essential component of treatment decisions. Gastrointestinal toxicity ...

    • Article  

      Treatment for Patients With Unknown Primary Carcinoma and Unfavorable Prognostic Factors 

      Greco, F. A.; Pavlidis, Nicholas (2009)
      The treatment for patients with unknown primary carcinoma, particularly those with unfavorable prognosis factors, has changed in the last decade, and continues to evolve. Empiric chemotherapy trials reported since 2000 ...

    • Article  

      Treatment of the pregnant mother with cancer: A systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part I: Solid tumors 

      Azim, Hatem A.; Peccatori, Fedro A.; Pavlidis, Nicholas (2010)
      The association of cancer and pregnancy is increasingly encountered nowadays in clinical practice. Due to the relative rarity of the situation, it lacks a systematized approach. Different systemic therapies are used in ...

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