Browsing by Subject "Fibroblasts"

Article

Atomic Force Microscopy Probing of Cancer Cells and Tumor Microenvironment Components

Stylianou, A.; Stylianopoulos, T. (2016)

Cancer cells have different characteristics from normal cells in terms of morphology, cell–cell interactions, cytoskeleton organization, cell growth rates, and cell-extracellular matrix interactions. Although the clarification ...

Article

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Jain, S. R.; Diop-Frimpong, B.; Bardeesy, N.; Smith, B. L.; Ferrone, C. R.; Hornicek, F. J.; Boucher, Y.; Munn, L. L.; Jain, R. K. (2012)

The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...

Article

Defining the role of solid stress and matrix stiffness in cancer cell proliferation and metastasis

Kalli, M.; Stylianopoulos, T. (2018)

Solid tumors are characterized by an abnormal stroma that contributes to the development of biomechanical abnormalities in the tumor microenvironment. In particular, these abnormalities include an increase in matrix stiffness ...

Article

Image-based multiscale modeling predicts tissue-level and network-level fiber reorganization in stretched cell-compacted collagen gels

Barocas, V. Η; Sander, E. A.; Stylianopoulos, T.; Tranquillo, R. T. (2009)

The mechanical environment plays an important role in cell signaling and tissue homeostasis. Unraveling connections between externally applied loads and the cellular response is often confounded by extracellular matrix ...

Article

Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration

Kalli, M.; Papageorgis, P.; Gkretsi, V.; Stylianopoulos, T. (2018)

Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated ...

Article

Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy

Mpekris, F.; Papageorgis, P.; Polydorou, C.; Voutouri, C.; Kalli, M.; Pirentis, A. P.; Stylianopoulos, T. (2017)

Targeting the rich extracellular matrix of desmoplastic tumors has been successfully shown to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical forces, improving tumor perfusion and chemotherapy. ...