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Browsing by Subject "Gene Expression Regulation, Neoplastic"

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    • Article  

      Prevention of preneoplastic mammary lesion development by a novel vitamin D analogue, 1α-hydroxyvitamin D5 

      Mehta, R. G.; Moriarty, R. M.; Mehta, R. R.; Penmasta, R.; Lazzaro, G.; Constantinou, Andreas I.; Guo, L. (1997)
      Background: The form of vitamin D (vitamin D3) in fortified milk and the provitamin D produced by the body undergo metabolic activation to a biologically active form, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3]. This compound ...

    • Article  

      Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance 

      Pitta, Chara A.; Papageorgis, P.; Charalambous, Christina; Constantinou, Andreas I. (2013)
      The purpose of this work is to determine the molecular mechanisms underlying tamoxifen resistance. We show here that ER-β is epigenetically silenced in a cell line with acquired tamoxifen resistance (MCF-7/TAM-R) and this ...

    • Article  

      Selective activation of TNFR1 and NF-ΚB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells 

      Savva, Christiana G.; Totokotsopoulos, S.; Nicolaou, K. C.; Neophytou, Christiana M.; Constantinou, Andreas I. (2016)
      Background: Acquired resistance towards apoptosis is a hallmark of cancer. Elimination of cells bearing activated oncogenes or stimulation of tumor suppressor mediators may provide a selection pressure to overcome resistance. ...

    • Article  

      Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells 

      Tonetti, D. A.; Rubenstein, R.; DeLeon, M.; Zhao, H.; Pappas, S. G.; Bentrem, D. J.; Chen, B.; Constantinou, Andreas I.; Jordan, V. C. (2003)
      We previously reported stable transfection of estrogen receptor alpha (ERα) into the ER-negative MDA-MB-231 cells (S30) as a tool to examine the mechanism of action of estrogen and antiestrogens [J. Natl. Cancer Inst. 84 ...

    • Article  

      Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis 

      Papageorgis, P.; Ozturk, S.; Lambert, A. W.; Neophytou, Christiana M.; Tzatsos, Alexandros; Wong, C. K.; Thiagalingam, S.; Constantinou, Andreas I. (2015)
      Introduction: Basal-like breast cancer (BLBC) is an aggressive subtype often characterized by distant metastasis, poor patient prognosis, and limited treatment options. Therefore, the discovery of alternative targets to ...

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