Browsing by Subject "Genes"
Now showing items 1-13 of 13
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Conference Object
Analysing cancer genomics in the elastic cloud
(Institute of Electrical and Electronics Engineers Inc., 2015)With the rapidly growing demand for DNA analysis, the need for storing and processing large-scale genome data has presented significant challenges. This paper describes how the Genome Analysis Toolkit (GATK) can be deployed ...
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Article
Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: Interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes
(2013)Background: More than half of patients with KRAS-wild type advanced colorectal cancer (CRC) fail anti-EGFR monoclonal antibodies. We studied EGFR-axis messenger RNA (mRNA) expression and RAS, RAF, PIK3CA mutations in order ...
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Article
BioTextQuest+: A knowledge integration platform for literature mining and concept discovery
(2014)The iterative process of finding relevant information in biomedical literature and performing bioinformatics analyses might result in an endless loop for an inexperienced user, considering the exponential growth of scientific ...
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Article
Complete coding sequence, exon/intron arrangement and chromosome location of ZNF45, a KRAB-domain-containing gene
(1996)Zinc finger genes represent a large multigene family present in mammalian and other genomes. A subgroup of these genes contain a conserved motif, the KRAB domain, at the NH2-terminal region, which was recently shown to ...
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Article
A cost-effective approach to improving performance of big genomic data analyses in clouds
(2017)With the rapidly growing demand for DNA analysis, the need for storing and processing large-scale genome data has presented significant challenges. This paper describes how the Genome Analysis Toolkit (GATK) can be deployed ...
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Article
Exploring the biology of cancer of unknown primary: Breakthroughs and drawbacks
(2013)Background: Cancer of unknown primary (CUP) ranks among the ten most common malignancies worldwide. Cancer of unknown primary presents as disseminated disease, has a dismal prognosis and remains a diagnosis of exclusion. ...
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Article
Interaction of metal complexes with G-quadruplex DNA
(2010)[Figure Presented] Guanine-rich sequences of DNA can assemble into tetrastranded structures known as G-quadruplexes. It has been suggested that these secondary DNA structures could be involved in the regulation of several ...
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Article
The missing kiss of life: Transcriptional activity of the metastasis suppressor gene KiSS1 in early breast cancer
(2007)Background: KiSS-1 is a metastasis suppressor gene encoding a neuropeptide with potent antimetastatic activities in tumour cell lines. The transcriptional activity of the gene and its associations in resected breast cancer ...
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Article
Prognostic significance of the deleted in colorectal cancer gene protein expression in high-risk resected gastric carcinoma
(2003)The deleted in colorectal cancer (DCC) gene is a candidate tumor suppressor gene that may be associated with differentiation and proliferation of normal cells. Loss of heterozygosity (LOH) of 18q, where the gene is located, ...
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Article
Statistical modelling and prognostic analysis in primary breast carcinoma
(2000)This work reports, for the first time, the results of the first retrospective study on breast cancer in Cyprus. The study which is based on 197 women with primary breast cancer who have undergone modified radical mastectomy ...
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Survivin and glycodelin transcriptional activity in node-positive early breast cancer: mRNA expression of two key regulators of cell survival
(2006)Introduction: Glycodelin and survivin are key polypeptide regulators of cellular proliferation, apoptosis and angiogenesis. In view of contradictory reports on their functional role in tumors, we studied their transcriptional ...
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Doctoral Thesis Open Access
Αστεροειδή πολυμερή και εφαρμογές τους στη μεταφορά DNA: πρότυπα αστεροειδή πλέγματα πολυμερών: διδακτορική διατριβή
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2006-07)Στη Διδακτορική αυτή Διατριβή έγινε η σύνθεση και ο χαρακτηρισμός κατιοντικών αστεροειδών πολυμερών και η αξιολόγηση τους στη μεταφορά γενετικού υλικού στα κύτταρα (επιμόλυνση). Επίσης, έγινε η σύνθεση και ο χαρακτηρισμός ...