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Browsing by Subject "Genetic predisposition to disease"

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    • Article  

      Association between the plasminogen activator inhibitor-1 4G/5G polymorphism and venous thrombosis 

      Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Rapti, E.; Mantzios, Georgios P.; Kapsimali, Violetta; Travlou, Anthi S. (2007)
      The effect of the 675 insertion/deletion (4G/5G) polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene on the risk of venous thromboembolism (VTE) remains controversial. In this study, we performed a meta-analysis ...

    • Article  

      The beginning of personalized medicine in sepsis: Small steps to a bright future 

      Christaki, Eirini; Giamarellos-Bourboulis, Evangelos J. (2014)
      There is a growing recognition that there is a need for a more personalized approach towards sepsis care. In most clinical trials investigating novel therapeutic interventions against sepsis, patients have been considered ...

    • Article  

      Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: Interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes 

      Pentheroudakis, George; Kotoula, V.; Roock, W. De; Kouvatseas, G.; Papakostas, P.; Makatsoris, T.; Papamichael, D.; Xanthakis, I.; Sgouros, J.; Televantou, D.; Kafiri, G.; Tsamandas, A. C.; Razi, E. D.; Galani, E.; Bafaloukos, Dimitrios; Efstratiou, I.; Bompolaki, I.; Pectasides, Dimitrios; Pavlidis, Nicholas; Tejpar, S.; Fountzilas, George (2013)
      Background: More than half of patients with KRAS-wild type advanced colorectal cancer (CRC) fail anti-EGFR monoclonal antibodies. We studied EGFR-axis messenger RNA (mRNA) expression and RAS, RAF, PIK3CA mutations in order ...

    • Article  

      The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host 

      Christaki, Eirini; Giamarellos-Bourboulis, Evangelos J. (2014)
      Bacteremia develops when bacteria manage to escape the host immune mechanisms or when the otherwise well-orchestrated immune response fails to control bacterial spread due to inherent or acquired immune defects that are ...

    • Article  

      Cytokine gene polymorphisms in multiple sclerosis: A meta-analysis of 45 studies including 7379 cases and 8131 controls 

      Nikolopoulos, Georgios K.; Masgala, Aikaterini; Tsiara, Chrissa G.; Limitsiou, O. K.; Karnaouri, Anthi C.; Dimou, Niki L.; Bagos, Pantelis G. (2011)
      Many environmental and genetic factors have been implicated in the development of multiple sclerosis. However, the aetiology has not been clarified yet. Therefore, using a meta-analytic approach, we tried to probe the ...

    • Article  

      The diagnosis and management of gastric cancer: Expert discussion and recommendations from the 12th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2010 

      Cutsem, E. van; Dicato, M.; Geva, R.; Arber, N.; Bang, Y.; Benson, A.; Cervantes, A.; Diaz-Rubio, E.; Ducreux, M.; Glynne-Jones, R.; Grothey, Axel; Haller, D.; Haustermans, K.; Kerr, D.; Nordlinger, B.; Marshall, J.; Minsky, B. D.; Kang, Y. K.; Labianca, R.; Lordick, F.; Ohtsu, A.; Pavlidis, Nicholas; Roth, A.; Rougier, P.; Schmoll, H. J.; Sobrero, A.; Tabernero, Josep; Velde, C. van de; Zalcberg, J. (2011)
      Well-recognized experts in the field of gastric cancer discussed during the 12th European Society Medical Oncology (ESMO)/World Congress Gastrointestinal Cancer (WCGIC) in Barcelona many important and controversial topics ...

    • Article  

      Generalized least squares for assessing trends in cumulative meta-analysis with applications in genetic epidemiology 

      Bagos, Pantelis G.; Nikolopoulos, Georgios K. (2009)
      Objective: Cumulative meta-analysis allows the evaluation of a study's contribution to the combined effect of the preceding research. It accrues evidence, gradually adding studies one at a time and provides updated estimates ...

    • Article  

      No evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: A meta-analysis 

      Bagos, Pantelis G.; Karnaouri, Anthi C.; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J. (2007)
      We conducted a meta-analysis concerning the association of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms with the risk of developing multiple sclerosis (MS). We identified 18 eligible studies ...

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