Browsing by Subject "Genistein"

Article

Dietary Soy Isoflavones and Estrone Protect Ovariectomized ERαKO and Wild-Type Mice from Carcinogen-Induced Colon Cancer

Guo, J. -Y; Li, X.; Browning Jr., J. D.; Rottinghaus, G. E.; Lubahn, D. B.; Constantinou, Andreas I.; Bennink, M.; MacDonald, R. S. (2004)

Consumption of soy foods has been weakly associated with reduced colon cancer risk. Colon cancer risk is influenced by estrogen exposure, although the mechanism through which this occurs is not defined. Conversion of ...

Article

Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells

Constantinou, Andreas I.; Kamath, N.; Murley, J. S. (1998)

The aim of this study was to identify the molecular mechanism of action of the isoflavone, genistein. Genistein at 0.15 mM caused MCF-7 apoptotic cell death, which was accompanied by cell cycle delay in the G2/M phase. ...

Article

Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells

Salti, G. I.; Grewal, S.; Mehta, R. R.; Das Gupta, T. K.; Boddie, A. W., Jr.; Constantinou, Andreas I. (2000)

The present study was undertaken to determine if (a) genistein induces topo II-mediated DNA damage in HT-29 colon cancer cells

Article

Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice

Constantinou, Andreas I.; Krygier, A. E.; Mehta, R. R. (1998)

Results of recent studies in animal models of mammary carcinogenesis showed that the soybean isoflavone genistein is a chemopreventive agent. The objective of the present study was to determine whether soybean isoflavones ...

Article

Induction of human adenocarcinoma cell differentiation by the phytoestrogen genistein is independent of its antiestrogenic function

Krygier, A. E.; Murley, J. S.; Mehta, R. R.; Constantinou, Andreas I. (1997)

The objective of the present study was to determine if genistein can induce human breast adenocarcinoma cell maturation. To gain understanding on its mechanism of action, we used estrogen receptor-positive (ER+) MCF-7, and ...

Article

The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours

Constantinou, Andreas I.; White, B. E. P.; Tonetti, D.; Yang, Y.; Liang, W.; Li, W.; Van Breemen, R. B. (2005)

The aim of this study was to determine how the efficacy of tamoxifen is affected when combined with soy isoflavones. To address this, female Sprague-Dawley rats were placed on diets supplemented with tamoxifen, genistein, ...

Article

Soy protein isolate prevents chemically-induced rat mammary tumors

Constantinou, Andreas I.; Morgan Lucas, L.; Lantvit, D.; Hawthorne, M.; Xu, X.; Chu, W. N.; Jeffery, E. H.; Christov, K.; Van Breemen, R. B.; Pezzuto, J. M. (2002)

purified daidzein at 200 mg/kg diet