Browsing by Subject "Glucose"
Now showing items 1-9 of 9
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Article
Assessment of the risk factors of coronary heart events based on data mining with decision trees
(2010)Coronary heart disease (CHD) is one of the major causes of disability in adults as well as one of the main causes of death in the developed countries. Although significant progress has been made in the diagnosis and treatment ...
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Conference Object
Assessment of the risk of coronary heart event based on data mining
(2008)Coronary heart disease (CHD) is a major cause of morbidity and mortality in the western world. Although significant progress has been made in the diagnosis and treatment of CHD, further investigation is still needed. The ...
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Conference Object
Association rule analysis for the assessment of the risk of coronary heart events
(2009)Although significant progress has been made in the diagnosis and treatment of coronary heart disease (CHD), further investigation is still needed. The objective of this study was to develop a data mining system using ...
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Article
Crystallographic and computational studies on 4-phenyl-N-(β-D- glucopyranosyl)-1H-1,2, 3-triazole-1-acetamide, an inhibitor of glycogen phosphorylase: Comparison with α-D-glucose, N-acetyl-β-D- glucopyranosylamine and N-benzoyl-N′-β-D-glucopyranosyl urea binding
(2008)4-Phenyl-N-(β-D-glucopyranosyl)-1H-1,2,3-triazole-1-acetamide (glucosyltriazolylacetamide) has been studied in kinetic and crystallographic experiments with glycogen phosphorylase b (GPb), in an effort to utilize its ...
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Article
Glucose-based spiro-isoxazolines: A new family of potent glycogen phosphorylase inhibitors
(2009)A series of glucopyranosylidene-spiro-isoxazolines was prepared through regio- and stereoselective [3+2]-cycloaddition between the methylene acetylated exo-glucal and aromatic nitrile oxides. The deprotected cycloadducts ...
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Article
Glycogen phosphorylase inhibitors: A free energy perturbation analysis of glucopyranose spirohydantoin analogues
(2005)GP catalyzes the phosphorylation of glycogen to Glc-1-P. Because of its fundamental role in the metabolism of glycogen, GP has been the target for a systematic structure-assisted design of inhibitory compounds, which could ...
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Article
Is the mortality rate for septic shock really decreasing?
(2008)Survival rates for patients in septic shock have gradually improved in critical care units worldwide over the last 25 years. Further improvement will be predicated on the discovery of new therapies to disrupt the underlying ...
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Article
Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase
(2005)Glycogen phosphorylase (GP) is currently exploited as a target for inhibition of hepatic glycogenolysis under high glucose conditions. Spirohydantoin of glucopyranose and N-acetyl-β-D-glucopyranosylamine have been identified ...
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Article
A switching control strategy for the attenuation of blood glucose disturbances
(2011)In this computational study we consider a generalized minimal model structure for the intravenously infused insulin-blood glucose dynamics, which can represent a wide variety of diabetic patients, and augment this model ...