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Browsing by Subject "Head and neck cancer"

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    • Article  

      Cancer and pregnancy: Poena magna, not anymore 

      Pentheroudakis, George; Pavlidis, Nicholas (2006)
      Cancer diagnosed during pregnancy constitutes a difficult clinical condition with a devastating impact on the patient's somatic and psychosocial health and possibly on foetal integrity. This circumstance also raises several ...

    • Article  

      Cancer and pregnancy: What should we know about the management with systemic treatment of pregnant women with cancer? 

      Pavlidis, Nicholas (2011)
      The incidence of cancer during pregnancy is a rare phenomenon and is estimated to occur in 1:1000 pregnancies. This co-existence is likely to rise since the delay of childbearing to the later reproductive age is nowadays ...

    • Article  

      Carzelesin phase II study in advanced breast, ovarian, colorectal, gastric, head and neck cancer, non-Hodgkin's lymphoma and malignant melanoma: A study of the EORTC early clinical studies group (ECSG) 

      Pavlidis, Nicholas; Aamdal, S.; Awada, Ahmad; Calvert, H.; Fumoleau, P.; Sorio, R.; Punt, C.; Verweij, J.; Oosterom, A. T. Van; Morant, R.; Wanders, J.; Hanauske, A. R. (2000)
      Purpose: In a phase II trial, the activity of carzelesin, a cyclopropylpyrroloindole prodrug analog, was assessed. Patients and methods: Carzelesin was used as second- or third-line chemotherapy in patients with breast, ...

    • Article  

      Human papillomavirus association with head and neck cancers: Understanding virus biology and using it in the development of cancer diagnostics 

      Strati, K.; Lambert, P. F. (2008)
      The link between human papillomaviruses (HPVs) and human cervical cancers has long been established. However, HPVs are now being detected in another type of cancer not previously associated with this virus, head and neck ...

    • Article  

      Multicentre phase II pharmacological evaluation of rhizoxin 

      McLeod, H. L.; Murray, L. S.; Wanders, J.; Setanoians, A.; Graham, M. A.; Pavlidis, Nicholas; Heinrich, B.; Huinink, W. W. Ten Bokkel; Wagener, D. J. Th; Aamdal, S.; Verweij, J. (1996)
      Rhizoxin is a macrocyclic lactone compound that binds to tubulin and inhibits microtubule assembly. Rhizoxin demonstrated preclinical anti-tumour activity against a variety of human tumour cell lines and xenograft models. ...

    • Article  

      Non-Hodgkin's Lymphomas in Greece according to the WHO classification of lymphoid neoplasms a retrospective analysis of 810 cases 

      Economopoulos, T.; Papageorgiou, S.; Dimopoulos, M. A.; Pavlidis, Nicholas; Tsatalas, C.; Symeonidis, A.; Foudoulakis, A.; Pectasides, Dimitrios; Rontogianni, D.; Rizos, E.; Chalkia, P.; Anagnostopoulos, A.; Melachrinou, M.; Papageorgiou, E.; Fountzilas, George (2005)
      The purpose of this retrospective study, the largest unselected series in our country, was to illustrate the clinicopathological features of non-Hodgkin's lymphoma (NHL) classified according to the World Health Organization ...

    • Article  

      Paclitaxel and gemcitabine vs. paclitaxel and pegylated liposomal doxorubicin in advanced non-nasopharyngeal head and neck cancer. An efficacy and cost analysis randomized study conducted by the Hellenic Cooperative Oncology Group 

      Fountzilas, George; Papakostas, P.; Dafni, U.; Makatsoris, T.; Karina, M.; Kalogera-Fountzila, Anna; Maniadakis, N.; Aravantinos, Gerasimos; Syrigos, K.; Bamias, A. T.; Christodoulou, C.; Economopoulos, T.; Kalofonos, H. P.; Nikolaou, A.; Angouridakis, N.; Stathopoulos, G. P.; Bafaloukos, Dimitrios; Pavlidis, Nicholas; Daniilidis, J. (2006)
      Background: The prognosis of patients with recurrent and/or metastatic head and neck cancer (HNC) is poor. Median survival of these patients following chemotherapy is in the range of 6 to 9 months. In the present randomized ...

    • Article  

      Paclitaxel by three-hour infusion and carboplatin in advanced carcinoma of nasopharynx and other sites of the head and neck: A phase II study conducted by the Hellenic Cooperative Oncology Group 

      Fountzilas, George; Skarlos, Dimosthenis V.; Athanasiades, A.; Kalogera-Fountzila, Anna; Samantas, E.; Bacoyiannis, Charalambos; Nicolaou, A.; Dombros, N.; Briassoulis, E. Ch; Dinopoulou, M.; Stathopoulos, G. P.; Pavlidis, Nicholas; Kosmidis, Paraskevas A.; Daniilidis, J. (1997)
      Background: Paclitaxel has been demonstrated to have significant activity in recurrent or metastatic head and neck cancer (HNC). In addition, the combination of paclitaxel and cisplatin is active in untreated patients with ...

    • Article  

      Paclitaxel in combination with carboplatin or gemcitabine for the treatment of advanced head and neck cancer 

      Fountzilas, George; Athanasiades, A.; Kalogera-Fountzila, Anna; Samantas, E.; Bacoyiannis, Charalambos; Briassoulis, E. Ch; Pavlidis, Nicholas; Kosmidis, Paraskevas A.; Skarlos, Dimosthenis V. (1997)
      We performed a phase II study to evaluate the activity and toxicity of the combination of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) and carboplatin as first-line treatment in patients with recurrent ...

    • Article  

      Paclitaxel, cisplatin, leucovorin, and continuous infusion fluorouracil followed by concomitant chemoradiotherapy for locally advanced squamous cell carcinoma of the head and neck: A hellenic cooperative oncology group phase II study 

      Fountzilas, George; Ch, F. Tolis; Kalogera-Fountzila, Anna; Misailidou, D.; Tsekeris, P.; Karina, M.; Nikolaou, A.; Samantas, E.; Makatsoris, T.; Athanassiou, E.; Skarlos, Dimosthenis V.; Bamias, A. T.; Zamboglou, N.; Economopoulos, T.; Karanastassi, S.; Pavlidis, Nicholas; Daniilidis, J. (2005)
      The primary objective of this phase II study was to access the complete response (CR) rate to a new innovative induction regimen in patients with locally advanced head and neck cancer (LA-HNC). From October 2000 until ...

    • Article  

      Perspectives for targeted therapies in cancer of unknown primary site 

      Pentheroudakis, George; Pavlidis, Nicholas (2006)
      Cancer of unknown primary site (CUP) ranks as the fourth most common cause of cancer deaths. Regression of the primary, early development of systemic metastases and resistance to therapy are hallmarks of this heterogeneous ...

    • Article  

      Primary extranodal non Hodgkin's lymphoma of the head and neck in adults: A clinicopathological comparison between tonsillar and non tonsillar lymphomas 

      Economopoulos, T.; Fountzilas, George; Kostourou, A.; Daniilidis, J.; Pavlidis, Nicholas; Andreopoulou, E.; Nicolaou, A.; Papageorgiou, E.; Mellou, S.; Dervenoulas, John; Stathakis, N. (1998)
      Primary extranodal NHL of the head and neck (HN-NHL) accounts for 10-20% of all cases of NHL. Despite their frequency, the natural history and biological behaviour of these lymphomas is poorly understood. In this study we ...

    • Article  

      Primary extranodal non-hodgkin's lymphoma of the head and neck 

      Economopoulos, T.; Asprou, N.; Stathakis, N.; Fountzilas, George; Pavlidis, Nicholas; Papaspyrou, S.; Dervenoulas, John; Belia, M.; Papageorgiou, E.; Theoharis, D.; Vrettou, E.; Raptis, S. (1992)
      Among 387 cases of non-Hodgkin's lymphoma (NHL) treated in our units between January 1977 and December 1990, 52 (13.4%) had primary extranodal (PE) NHL of the head and neck. The median age was 55 years with a M:F ratio of ...

    • Article  

      Prognostic factors influencing complete response to treatment and survival of patients with nasopharyngeal cancer 

      Kalogera-Fountzila, Anna; Kosmidis, Paraskevas A.; Bacoyiannis, Charalambos; Nicolaou, A.; Samantas, E.; Briassoulis, E. Ch; Pavlidis, Nicholas; Skarlos, Dimosthenis V.; Daniilidis, J.; Fountzilas, George (1998)
      The identification of prognostic factors influencing local control and survival of patients with nasopharyngeal cancer (NPC) might help in pointing out those patients who would probably benefit from primary treatment. A ...

    • Article  

      Radiation and concurrent carboplatin administration in locally advanced head and neck cancer 

      Fountzilas, George; Skarlos, Dimosthenis V.; Nikolaou, A.; Kalogera-Fountzila, Anna; Tzitzikas, J.; Kosmidis, Paraskevas A.; Makrantonakis, P.; Samantas, E.; Karpasitis, N.; Bacoyiannis, Charalambos; Synodinou, M.; Pavlidis, Nicholas; Vritsios, A.; Daniilidis, J. (1995)
      Aims and Background: To improve local control in patients with locally advanced inoperable head and neck cancer we administered carboplatin concurrently with radiation. Methods: Thirty-nine patients entered the study. There ...

    • Article  

      The role of human papilloma virus and p16 in occult primary of the head and neck: A comprehensive review of the literature 

      Fotopoulos, George; Pavlidis, Nicholas (2015)
      Cancer of unknown primary of the head and neck is a challenging entity for the oncologist. The role of human papilloma virus/p16 in carcinogenesis and in prognosis is well established in certain HNSCC especially in that ...

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