Browsing by Subject "Hepatitis C virus"

Doctoral Thesis Open Access

Genetic studies on the Hepatitis C virus

Demetriou, Victoria L. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2010-12)

Το κείμενο αυτό ασχολείται με την μελέτη της γενετικής ποικιλότητας του HCV. Στο πρώτο μέρος περιγράφεται για πρώτη φορά η μοριακή επιδημιολογία της HCV λοίμωξης στην Κύπρο ανάμεσα στο γενικό πληθυσμό και σε ομάδες υψηλού ...

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Hepatitis C infection among intravenous drug users attending therapy programs in Cyprus

Demetriou, Victoria L.; Van De Vijver, D. A. M. C.; Hezka, Johana; Kostrikis, Leontios G.; Savvopoulou, Natasa; Georgiades, Neoklis; Charilaou, Charis C.; Argyriou, Argyris; Pavlou, Tina; Platritis, Kyriakos; Veresies, Kyriakos L. (2010)

The most high-risk population for HCV transmission worldwide today are intravenous drug users. HCV genotypes in the general population in Cyprus demonstrate a polyphyletic infection and include subtypes associated with ...

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Hepatitis C infection among intravenous drug users attending therapy programs in Cyprus (Journal of Medical Virology (2010) 82, (263-270))

Demetriou, Victoria L.; Van De Vijver, D. A. M. C.; Hezka, Johana; Kostrikis, Leontios G. (2010)

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Identification of a series of novel derivatives as potent HCV inhibitors by a ligand-based virtual screening optimized procedure

Melagraki, G.; Afantitis, Antreas; Sarimveis, H.; Koutentis, Panayiotis Andreas; Markopoulos, J.; Igglessi-Markopoulou, O. (2007)

This paper presents the results of a ligand-based virtual screening optimized procedure on 98 compounds which have been recently evaluated as inhibitors of genotype 1 HCV polymerase. First, quantitative structure-activity ...

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Molecular epidemiology of hepatitis C infection in Cyprus within the general population and high-risk cohorts

Demetriou, Victoria L.; Kostrikis, Leontios G. (2011)

Background: Initial data on the molecular epidemiology of HCV infection in Cyprus showed a highly polyphyletic infection and multiple points of introduction into the general population. The continuation and expansion of ...

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Molecular epidemiology of hepatitis C infection in cyprus: Evidence of polyphyletic infection

Demetriou, Victoria L.; Van De Vijver, D. A. M. C.; Kostrikis, Leontios G.; Chimonides, S.; Evgeniou, N. A.; Hadjigeorgiou-Vounou, E.; Koliou-Mazeri, M.; Papakyriakou, P.; Petsas, L.; Potamitis, G. (2009)

The genetic diversity of the hepatitis C virus (HCV) in Cyprus is investigated for the first time in this study. Nucleotide sequence analysis of the CORE-E1 and NS5B regions of the HCV genome was performed on blood plasma ...

Article

Near-full genome characterisation of two natural intergenotypic 2k/1b recombinant hepatitis c virus isolates

Demetriou, Victoria L.; Kyriakou, Eftychia; Kostrikis, Leontios G. (2011)

Few natural intergenotypic hepatitis C virus (HCV) recombinants have been characterised, and only RF1-2k/1b has demonstrated widespread transmission. The near-full length genome sequences for two cases of 2k/1b recombinants ...

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Near-full genome characterization of unclassified hepatitis c virus strains relating to genotypes 1 and 4

Demetriou, Victoria L.; Kostrikis, Leontios G. (2011)

Near-full genome sequences are presented in this report for the first time of unclassified HCV strains amplified using RT-PCR from plasma of patients living in Cyprus. One strain appears to be a unique genotype-1-like ...

Article

Re-analysis of unassigned hepatitis C virus (HCV) strain CYHCV025: Evidence of a highly divergent lineage within genotype 1

Oikonomopoulou, M.; Demetriou, Victoria L.; Kostrikis, Leontios G.; Paraskevis, Dimitrios N. (2017)

HCV global sequences have been classified into 7 genotypes, several subtypes and a number of unassigned sequences. Our aim was to perform an in depth investigation of the taxonomic relationships of the unclassified CYHCV025 ...