Browsing by Subject "Immunity"

Article

The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host

Christaki, Eirini; Giamarellos-Bourboulis, Evangelos J. (2014)

Bacteremia develops when bacteria manage to escape the host immune mechanisms or when the otherwise well-orchestrated immune response fails to control bacterial spread due to inherent or acquired immune defects that are ...

Article

A fragment of the alarmin prothymosin α as a novel biomarker in murine models of bacteria-induced sepsis

Samara, Pinelopi; Miriagou, Vivì; Zachariadis, Michael; Mavrofrydi, Olga; Promponas, Vasilis J.; Dedos, Skarlatos G.; Papazafiri, Panagiota; Kalbacher, H.; Voelter, W.; Tsitsilonis, Ourania E. (2017)

Sepsis is a life-threatening condition that requires urgent care. Thus, the identification of specific and sensitive biomarkers for its early diagnosis and management are of clinical importance. The alarmin prothymosin ...

Article

Host immune response in sepsis due to ventilator-associated pneumonia: How is it different?

Christaki, Eirini (2009)

Current evidence regarding potentially different host response mechanisms in sepsis according to the type of initiating infection is sporadic. It is possible that alterations in cell populations, variations in effector ...

Article

Immunomodulatory therapy for sepsis: An update

Christaki, Eirini; Anyfanti, Panagiota; Opal, Steven M. (2011)

Currently the treatment mainstay of sepsis is early and appropriate antibiotic therapy, accompanied by aggressive fluid administration, the use of vasopressors when needed and the prompt initiation of measures to support ...

Article

In vivo high-resolution magic angle spinning magnetic resonance spectroscopy of Drosophila melanogaster at 14.1 T shows trauma in aging and in innate immune-deficiency is linked to reduced insulin signaling

Righi, V.; Apidianakis, Yiorgos; Mintzopoulos, D.; Astrakas, L.; Rahme, L. G.; Tzika, A. A. (2010)

In vivo magnetic resonance spectroscopy (MRS), a non-destructive biochemical tool for investigating live organisms, has yet to be used in the fruit fly Drosophila melanogaster, a useful model organism for investigating ...

Article

Intestinal Stem Cells: A Decade of Intensive Research in Drosophila and the Road Ahead

Apidianakis, Yiorgos; Tamamouna, V.; Teloni, S.; Pitsouli, Chrysoula (2017)

Since the molecular characterization of Drosophila midgut progenitors in 2006, a few hundred articles studying fly intestinal stem cells have already been published. There was a relative lag phase in creating new knowledge ...

Article

Macrophage involvement in the antitumor activity of Brucella abortus ether extract against experimental lung carcinoma metastases

Schultz, R. M.; Pavlidis, Nicholas; Chirigos, M. A. (1978)

Article

Regulation of macrophage tumoricidal function: a role for prostaglandins of the E series

Schultz, R. M.; Pavlidis, Nicholas; Stylos, W. A.; Chirigos, M. A. (1978)

Exogenously added prostaglandins E1 and E2, but not F2alpha, inhibited the tumoricidal activity of interferon-activated macrophages of mice. A role for adenosine 3',5'-monophosphate (cyclic AMP) in modulating macrophage ...