Browsing by Subject "Isoflavones"

Article

Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats

Constantinou, Andreas I.; Lantvit, D.; Hawthorne, M.; Xu, X.; Van Breemen, R. B.; Pezzuto, J. M. (2001)

There are conflicting reports on the effect of soy and its components on mammary carcinogenesis in adult female rats, mainly because of different rodent models that are used in chemoprevention studies. The present study ...

Article

Dietary Soy Isoflavones and Estrone Protect Ovariectomized ERαKO and Wild-Type Mice from Carcinogen-Induced Colon Cancer

Guo, J. -Y; Li, X.; Browning Jr., J. D.; Rottinghaus, G. E.; Lubahn, D. B.; Constantinou, Andreas I.; Bennink, M.; MacDonald, R. S. (2004)

Consumption of soy foods has been weakly associated with reduced colon cancer risk. Colon cancer risk is influenced by estrogen exposure, although the mechanism through which this occurs is not defined. Conversion of ...

Article

The effect of the phytoestrogens genistein, daidzein, and equol on the growth of tamoxifen-resistant T47D/PKCα

Tonetti, D. A.; Zhang, Y.; Zhao, H.; Lim, S. -B; Constantinou, Andreas I. (2007)

Soy supplements are often consumed by women for alleviating menopausal symptoms or for the perceived protective effects against breast cancer. More concerning is the concurrent consumption of soy isoflavones with tamoxifen ...

Article

Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms

Liu, J.; Burdette, J. E.; Xu, H.; Gu, C.; Van Breemen, R. B.; Bhat, K. P. L.; Booth, N.; Constantinou, Andreas I.; Pezzuto, J. M.; Fong, H. H. S.; Farnsworth, N. R.; Bolton, J. L. (2001)

Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red clover (Trifolium pratense L.), chasteberry (Vitex agnus-castus ...

Article

Genistein as an Inducer of Tumor Cell Differentiation: Possible Mechanisms of Action

Constantinou, Andreas I.; Huberman, E. (1995)

Decreased activity of either topoisomerases or tyrosine kinases has been implicated in the differentiation of a number of cell types. It is therefore conceivable that genistein, because of its reported ability to inhibit ...

Article

Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice

Constantinou, Andreas I.; Krygier, A. E.; Mehta, R. R. (1998)

Results of recent studies in animal models of mammary carcinogenesis showed that the soybean isoflavone genistein is a chemopreventive agent. The objective of the present study was to determine whether soybean isoflavones ...

Article

Genistein-induced cell differentiation and protein-linked DNA strand breakage in human melanoma cells

Kiguchi, K.; Constantinou, Andreas I.; Huberman, E. (1990)

Article

Induction of Differentiation and DNA Strand Breakage in Human HL-60 and K-562 Leukemia Cells by Genistein

Constantinou, Andreas I.; Kiguchi, K.; Huberman, E. (1990)

Genistein, an in vitro inhibitor of topoisomerase II and tyrosine kinases, suppressed growth and induced differentiation in HL-205 cells, a clonal population of the human promyelocytic HL-60 leukemia cells, and in K-562-J ...

Article

Induction of human adenocarcinoma cell differentiation by the phytoestrogen genistein is independent of its antiestrogenic function

Krygier, A. E.; Murley, J. S.; Mehta, R. R.; Constantinou, Andreas I. (1997)

The objective of the present study was to determine if genistein can induce human breast adenocarcinoma cell maturation. To gain understanding on its mechanism of action, we used estrogen receptor-positive (ER+) MCF-7, and ...

Article

Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones

Constantinou, Andreas I.; Mehta, R. G.; Vaughan, A. (1996)

Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against breast and prostate cancer. Soy-based diets, rich in the isoflavones genistein and daidzein, are thought to protect against ...

Article

Isolation of isoflavones from soy-based fermentations of the erythromycin-producing bacterium Saccharopolyspora erythraea

Hessler, P. E.; Larsen, P. E.; Constantinou, Andreas I.; Schram, K. H.; Weber, J. M. (1997)

A search for an abundant and economical source of isoflavones, particularly genistein, led to the discovery that the erythromycin-producing organism Saccharopolyspora erythraea also produces this promising new cancer-prevention ...

Article

Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex

Constantinou, Andreas I.; Husband, A. (2002)

Cancer therapeutic drugs that inhibit DNA topoisomerase (topo) II by stabilizing the cleavable complex are collectively known as topo II poisons. Phenoxodiol is a synthetic derivative of the plant isoflavone daidzein and ...

Article

Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats

Constantinou, Andreas I.; Mehta, R.; Husband, A. (2003)

The present study was undertaken to evaluate the potential cancer chemopreventive effects of novel synthetic derivatives of isoflavones. Initially these agents were tested in a mouse mammary organ culture (MMOC) model. ...

Article

Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro and in vivo

Georgaki, Sylvianna; Skopeliti, Margarita; Tsiatas, Marinos L.; Nicolaou, Katerina A.; Ioannou, Kyriaki; Husband, A.; Bamias, Aristotelis T.; Dimopoulos, Meletios A.; Constantinou, Andreas I.; Tsitsilonis, Ourania E. (2009)

Phenoxodiol (PXD) is a synthetic analogue of the plant isoflavone genistein with improved anticancer efficacy. Various properties and mechanisms of action have been attributed to the drug, the most important being its ...

Article

The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours

Constantinou, Andreas I.; White, B. E. P.; Tonetti, D.; Yang, Y.; Liang, W.; Li, W.; Van Breemen, R. B. (2005)

The aim of this study was to determine how the efficacy of tamoxifen is affected when combined with soy isoflavones. To address this, female Sprague-Dawley rats were placed on diets supplemented with tamoxifen, genistein, ...

Article

Soy protein isolate prevents chemically-induced rat mammary tumors

Constantinou, Andreas I.; Morgan Lucas, L.; Lantvit, D.; Hawthorne, M.; Xu, X.; Chu, W. N.; Jeffery, E. H.; Christov, K.; Van Breemen, R. B.; Pezzuto, J. M. (2002)

purified daidzein at 200 mg/kg diet

Article

Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized sprague-dawley rats

Burdette, J. E.; Liu, J.; Lantvit, D.; Lim, E.; Booth, N.; Bhat, K. P. L.; Hedayat, S.; Van Breemen, R. B.; Constantinou, Andreas I.; Pezzuto, J. M.; Farnsworth, N. R.; Bolton, J. L. (2002)

Studies were conducted using an ovariectomized rat model to determine the estrogenic and antiestrogenic activity of Trifolium pratense L. (red clover) extracts. A red clover extract, standardized to contain 15% isoflavones ...