Browsing by Subject "Isothiazole"

Now showing items 1-3 of 3

    • Article  

      1,2,3-Dithiazole chemistry in heterocyclic synthesis 

      Christoforou, Irene C.; Koutentis, Panayiotis Andreas; Michaelidou, Sophia S. (2006)
      The chemistry of various 5H-1,2,3-dithiazoles is investigated with emphasis on assisted ring opening and ring closure reactions leading to new heterocycles. Thus on treatment with catalytic tetraalkylammonium iodide ...
    • Article  

      In silico exploration for identifying structure-activity relationship of MEK inhibition and oral bioavailability for isothiazole derivatives 

      Melagraki, G.; Afantitis, Antreas; Sarimveis, H.; Igglessi-Markopoulou, O.; Koutentis, Panayiotis Andreas; Kollias, G. (2010)
      In this study, quantitative structure-activity/property models are developed for modeling and predicting both MEK inhibitory activity and oral bioavailability of novel isothiazole-4-carboxamidines. The models developed are ...
    • Article  

      Tert-Butyl 3-(4-Cyano-5-phenylisothiazol-3-yl)carbazate 

      Ioannidou, Heraklidia A.; Koutentis, Panayiotis Andreas (2009)
      3-Iodo-5-phenylisothiazole-4-carbonitrile 1 reacts with tert-butyl carbazate via a Buchwald C-N style coupling to afford tert-butyl 3-(4-cyano-5-phenylisothiazol-3-yl)-carbazate 2 in 70% yield. © 2009 by the authors.