Browsing by Subject "Mammalia"

Article

Application of topoisomerase assays in the evaluation of natural products as antitumor agents

Constantinou, Andreas I.; Salti, G. (1999)

Initially, DNA topoisomerase (topo) inhibitors found clinical applications as antibiotics and cancer chemotherapeutic agents. Recently, we demonstrated that plant flavonoids that inhibit mammalian topo I or topo II might ...

Article

Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation

Kirmizis, Antonis; Santos-Rosa, H.; Penkett, C. J.; Singer, M. A.; Vermeulen, M.; Mann, M.; Bähler, J.; Green, R. D.; Kouzarides, T. (2007)

Modifications on histones control important biological processes through their effects on chromatin structure. Methylation at lysine 4 on histone H3 (H3K4) is found at the 5′ end of active genes and contributes to ...

Article

Birdsong tuned to the environment: Green hylia song varies with elevation, tree cover, and noise

Kirschel, A. N. G.; Blumstein, Daniel T.; Cohen, R. E.; Buermann, W.; Smith, T. B.; Slabbekoorn, H. (2009)

Animals that communicate acoustically must compete for acoustic space in order to convey their signals effectively. Tropical rainforest birds live in an extremely diverse acoustic community consisting of other birds, ...

Article

Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response

Apidianakis, Yiorgos; Rahme, L. G.; Heitman, J.; Ausubel, F. M.; Calderwood, S. B.; Mylonakis, E. (2004)

We found that the ingestion of Cryptococcus neoformans by Drosophila melanogaster resulted in the death of the fly but that the ingestion of Saccharomyces cerevisiae or the nonpathogenic Cryptococcus kuetzingii or Cryptococcus ...

Article

Design of a modified mouse protein with ligand binding properties of its human analog by molecular dynamics simulations: The case of C3 inhibition by compstatin

Tamamis, Phanourios; Pierou, P.; Mytidou, C.; Floudas, C. A.; Morikis, D.; Archontis, Georgios Z. (2011)

The peptide compstatin and its derivatives inhibit the complement-component protein C3 in primate mammals and are potential therapeutic agents against the unregulated activation of complement in humans, but are inactive ...

Article

Differential expression of the rat retinoid X receptor γ gene during skeletal muscle differentiation suggests a role in myogenesis

Georgiades, Pantelis; Brickell, P. M. (1997)

Even though previous studies have shown that transcripts encoding the murine retinoid X receptor γ (RXRγ) are present in skeletal muscle of mouse embryos and that cultured myoblasts are induced to differentiate upon retinoid ...

Article

Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection

Apidianakis, Yiorgos; Que, Y. -A; Xu, W.; Tegos, G. P.; Zimniak, P.; Hamblin, M. R.; Tompkins, R. G.; Xiao, W.; Rahme, L. G. (2012)

Patients with severe burns are highly susceptible to bacterial infection. While immunosuppression facilitates infection, the contribution of soft tissues to infection beyond providing a portal for bacterial entry remains ...

Article

Drosophila melanogaster as a model for human intestinal infection and pathology

Apidianakis, Yiorgos; Rahme, L. G. (2011)

Recent findings concerning Drosophila melanogaster intestinal pathology suggest that this model is well suited for the study of intestinal stem cell physiology during aging, stress and infection. Despite the physiological ...

Article

Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection

Apidianakis, Yiorgos; Rahme, L. G. (2009)

Conservation of host signaling pathways and tissue physiology between Drosophila melanogaster and mammals allows for the modeling of human host-pathogen interactions in Drosophila. Here we present the use of genetically ...

Article

Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development

Georgiades, Pantelis; Rossant, J. (2006)

Although the trophoblast is necessary for the growth, viability and patterning of the mammalian embryo, understanding of its patterning role is still rudimentary. Expression of the transcription factor Ets2 is restricted ...

Article

Haploinsufficiency of the miR-873/miR-876 microRNA cluster is associated with craniofacial abnormalities

Koufaris, Costas; Papagregoriou, Gregory N.; Kousoulidou, Ludmila; Moutafi, Maria; Tauber, Maïthé Thérèse; Jouret, Béatrice; Kieffer, Isabelle; Constantinou-Deltas, Constantinos D.; Tanteles, George A.; Anastasiadou, Violetta C.; Patsalis, Philippos C.; Sismani, Carolina (2015)

MicroRNA haploinsufficiency has been associated with developmental defects in only a limited number of cases. Here we report a de novo genomic microdeletion that includes the LINGO2 gene as well as two microRNA genes, ...

Article

Homeostasis in Infected Epithelia: Stem Cells Take the Lead

Pitsouli, Chrysoula; Apidianakis, Yiorgos; Perrimon, N. (2009)

To maintain tissue homeostasis and avoid disease, epithelial cells damaged by pathogens need to be readily replenished, and this is mainly achieved by the activation of stem cells. In this Short Review, we discuss recent ...

Article

The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis

Kypri, Elena; Christodoulou, A.; Maimaris, G.; Lethan, M.; Markaki, M.; Lysandrou, C.; Lederer, C. W.; Tavernarakis, N.; Geimer, S.; Pedersen, L. B.; Santama, Niovi (2014)

Nucleotide-binding proteins Nubp1 and Nubp2 are MRP/MinD-type P-loop NTPases with sequence similarity to bacterial division site-determining proteins and are conserved, essential proteins throughout the Eukaryotes. They ...

Article

The Polycomb Group Protein SUZ12 regulates histone H3 lysine 9 methylation and HP1α distribution

De La Cruz, C. C.; Kirmizis, Antonis; Simon, M. D.; Isono, K. -I; Koseki, H.; Panning, B. (2007)

Regulation of histone methylation is critical for proper gene expression and chromosome function. Suppressor of Zeste 12 (SUZ12) is a requisite member of the EED/EZH2 histone methyltransferase complexes, and is required ...

Article

Regulation of retinoid X receptor-γ gene transcript levels in rat heart cells

Georgiades, Pantelis; Brickell, P. M. (1998)

Retinoid X receptor-γ (RXRγ) is a transcription factor that mediates retinoid signalling and is expressed in rat heart during adult life. However, its expression in embryonic and neonatal heart has not been investigated ...

Article

Spatially and temporally regulated α6 integrin cleavage during Xenopus laevis development

Demetriou, Manolis C.; Stylianou, Panayiota; Andreou, Maria I.; Yiannikouri, Olga; Tsaprailis, George; Cress, Anne E.; Skourides, Paris A. (2008)

The α6 integrin is essential for early nervous system development in Xenopus laevis. We have previously reported a uPA cleaved form of integrin α6 (α6p), in invasive human prostate cancer tissue, whose presence correlates ...

Article

Species specificity of the complement inhibitor compstatin investigated by all-atom molecular dynamics simulations

Tamamis, Phanourios; Morikis, D.; Floudas, C. A.; Archontis, Georgios Z. (2010)

The development of compounds to regulate the activation of the complement system in non-primate species is of profound interest because it can provide models for human diseases. The peptide compstatin inhibits protein C3 ...

Article

Time-resolved step-scan Fourier transform infrared investigation of heme-copper oxidases: Implications for O2 input and H 2O/H+ output channels

Koutsoupakis, Constantinos; Pinakoulaki, Eftychia; Stavrakis, Stavros; Daskalakis, Vangelis; Varotsis, Constantinos (2004)

We have applied FTIR and time-resolved step-scan Fourier transform infrared (TRS2-FTIR) spectroscopy to investigate the dynamics of the heme-CuB binuclear center and the protein dynamics of mammalian aa3, Pseudomonas ...