Browsing by Subject "Mathematical modeling"
Now showing items 1-6 of 6
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Article
Biphasic modeling of brain tumor biomechanics and response to radiation treatment
(2016)Biomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical ...
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Article
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
(2012)The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...
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Article
Combining two strategies to improve perfusion and drug delivery in solid tumors
(2013)Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a ...
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Conference Object
Mechanical stress regulates tissue oxygenation, cancer cell proliferation and drug delivery during progression of solid tumors
(Springer Verlag, 2016)Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
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Article
Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery
(2015)Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
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Article
Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors
(2015)Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...