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Browsing by Subject "Mathematical modeling"

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    • Article  

      Biphasic modeling of brain tumor biomechanics and response to radiation treatment 

      Angeli, S.; Stylianopoulos, T. (2016)
      Biomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical ...

    • Article  

      Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors 

      Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Jain, S. R.; Diop-Frimpong, B.; Bardeesy, N.; Smith, B. L.; Ferrone, C. R.; Hornicek, F. J.; Boucher, Y.; Munn, L. L.; Jain, R. K. (2012)
      The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...

    • Article  

      Combining two strategies to improve perfusion and drug delivery in solid tumors 

      Stylianopoulos, T.; Jain, R. K. (2013)
      Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a ...

    • Article  

      Evidence for recent selection of the CCR5-Δ32 deletion from differences in its frequency between Ashkenazi and Sephardi Jews 

      Maayan, S.; Zhang, L.; Shinar, E.; Ho, J.; He, T.; Manni, N.; Kostrikis, Leontios G.; Neumann, A. U. (2000)
      Recent studies have shown higher frequencies of the CCR5-Δ32 allele and the CCR5-A32/Δ32 genotype, which confers protection against HIV infection, in northern Europe as compared to Mediterranean countries. Here, we analyse ...

    • Conference Object  

      Mechanical stress regulates tissue oxygenation, cancer cell proliferation and drug delivery during progression of solid tumors 

      Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (Springer Verlag, 2016)
      Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...

    • Article  

      Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery 

      Mpekris, F.; Angeli, S.; Pirentis, A. P.; Stylianopoulos, T. (2015)
      Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...

    • Article  

      Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors 

      Stylianopoulos, Triantafyllos; Economides, Eva Athena; Baish, J. W.; Fukumura, D.; Jain, R. K. (2015)
      Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...

    • Article  

      Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors 

      Stylianopoulos, T.; Economides, E. A.; Baish, J. W.; Fukumura, D.; Jain, R. K. (2015)
      Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...

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