Browsing by Subject "Meta analysis (topic)"

Article

The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: A mendelian randomization meta-analysis

Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Tsangaris, I.; Tsiara, Chrissa G.; Kopterides, Petros; Vaiopoulos, A.; Kapsimali, Violetta; Bonovas, Stefanos; Tsantes, Argirio E. (2014)

Background: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found ...

Article

The beginning of personalized medicine in sepsis: Small steps to a bright future

Christaki, Eirini; Giamarellos-Bourboulis, Evangelos J. (2014)

There is a growing recognition that there is a need for a more personalized approach towards sepsis care. In most clinical trials investigating novel therapeutic interventions against sepsis, patients have been considered ...

Article

The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host

Christaki, Eirini; Giamarellos-Bourboulis, Evangelos J. (2014)

Bacteremia develops when bacteria manage to escape the host immune mechanisms or when the otherwise well-orchestrated immune response fails to control bacterial spread due to inherent or acquired immune defects that are ...

Article

Developing the evidence base for cancer chemoprevention: Use of meta-analysis

Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Bonovas, Stefanos (2011)

Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. It answers a specific research question, includes an ...

Article

The diagnosis and management of gastric cancer: Expert discussion and recommendations from the 12th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2010

Cutsem, E. van; Dicato, M.; Geva, R.; Arber, N.; Bang, Y.; Benson, A.; Cervantes, A.; Diaz-Rubio, E.; Ducreux, M.; Glynne-Jones, R.; Grothey, Axel; Haller, D.; Haustermans, K.; Kerr, D.; Nordlinger, B.; Marshall, J.; Minsky, B. D.; Kang, Y. K.; Labianca, R.; Lordick, F.; Ohtsu, A.; Pavlidis, Nicholas; Roth, A.; Rougier, P.; Schmoll, H. J.; Sobrero, A.; Tabernero, Josep; Velde, C. van de; Zalcberg, J. (2011)

Well-recognized experts in the field of gastric cancer discussed during the 12th European Society Medical Oncology (ESMO)/World Congress Gastrointestinal Cancer (WCGIC) in Barcelona many important and controversial topics ...

Article

Efficacy and safety of more intensive lowering of LDL cholesterol [1]

Bonovas, Stefanos; Nikolopoulos, Georgios K.; Sitaras, N. M. (2011)

Article

Meta-analysis of family-based and case-control genetic association studies that use the same cases

Bagos, Pantelis G.; Dimou, Niki L.; Liakopoulos, Theodore D.; Nikolopoulos, Georgios K. (2011)

In many cases in genetic epidemiology, the investigators in an effort to control for different sources of confounding and simultaneously to increase the power perform a family-based and a population-based case-control study ...

Article

On the criteria used for assessing the risk of bias in randomized trials included in systematic reviews and meta-analyses addressing adverse effects

Bonovas, Stefanos; Lytras, Theodoros; Nikolopoulos, Georgios K. (2015)