Browsing by Subject "Methylation"
Now showing items 1-4 of 4
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Article
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation
(2005)Changes in the substrate specificities of factors that irreversibly modify the histone components of chromatin are expected to have a profound effect on gene expression through epigenetics. Ezh2 is a histone-lysine ...
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Article
Cross-talk among epigenetic modifications: Lessons from histone arginine methylation
(2013)Epigenetic modifications, including those occurring on DNA and on histone proteins, control gene expression by establishing and maintaining different chromatin states. In recent years, it has become apparent that epigenetic ...
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Doctoral Thesis Open Access
Methylome and transcriptome - towards non invasive prenatal diagnosis
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2015-05)Η μη-επεμβατική προγεννητική διάγνωση αποτέλεσε ένα από τους πιο απαιτητικούς ερευνητικούς τομείς των δύο τελευταίων δεκαετιών. Η ανακάλυψη της παρουσίας ελεύθερου εμβρυϊκού DNA στην μητρική κυκλοφορία αποτέλεσε κινητήριο ...
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Article
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27
(2004)Polycomb group (PcG) complexes 2 and 3 are involved in transcriptional silencing. These complexes contain a histone lysine methyltransferase (HKMT) activity that targets different lysine residues on histones H1 or H3 in ...