Browsing by Subject "Mice"
Now showing items 1-20 of 31
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Analgesic tolerance and cross-tolerance to i.c.v. endomorphin-1, endomorphin-2, and morphine in mice; 15276249
(2004)The present study examined the development of analgesic tolerance to endomorphin-1 (EM1), endomorphin-2 (EM2), and morphine, and cross-tolerance among these drugs. Male Swiss Webster mice were injected i.c.v. with EM1, ...
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Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
(2013)Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...
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Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
(2012)The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...
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Coevolution of solid stress and interstitial fluid pressure in tumors during progression: Implications for vascular collapse
(2013)The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or induced by the tumor itself due to its growth. Fluid pressure is ...
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Cytotoxic activity of interferon-treated macrophages studied by various inhibitors
(1978)The ability of interferon-treated macrophages to kill or inhibit the growth of tumor cells is markedly influenced by the local environment. The macrophage cytotoxic effector system is regulated by serum and other environmental ...
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Effect of maleic anhydride-divinyl ether copolymers on experimental M109 metastases and macrophage tumoricidal function
(1978)Pyran copolymer (NSC-46015) was compared with five maleic anhydride-divinyl ether copolymers (MVEs) of narrow molecular weight range both for the ability to render macrophages nonspecifically tumoricidal and to retard the ...
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Effects of adriamycin and cyclophosphamide treatment on induction of macrophage cytotoxic function in mice
(1979)The effects of i.p. and s.c. Adriamycin and cyclophosphamide treatment of BALB/c x DBA/2F1 mice were studied alone and in combination with immunotherapeutic agents, pyran copolymer and Bacillus Calmette-Guérin, on macrophage ...
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Estrogen receptor β agonism increases survival in experimentally induced sepsis and ameliorates the genomic sepsis signature: A pharmacogenomic study
(2010)Background. Nonsteroidal agonists have been developed that selectively bind to and activate estrogen receptor β (ERβ) rather than estrogen receptor α (ERα). ERβ is expressed equally in both male and female mammals in ...
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Hyaluronan-Derived Swelling of Solid Tumors, the Contribution of Collagen and Cancer Cells, and Implications for Cancer Therapy
(2016)Despite the important role that mechanical forces play in tumor growth and therapy, the contribution of swelling to tumor mechanopathology remains unexplored. Tumors rich in hyaluronan exhibit a highly negative fixed charge ...
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Immunomodulatory therapy for sepsis: An update
(2011)Currently the treatment mainstay of sepsis is early and appropriate antibiotic therapy, accompanied by aggressive fluid administration, the use of vasopressors when needed and the prompt initiation of measures to support ...
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Macrophage activation and antitumor activity of a Brucella abortus ether extract, Bru-Pel
(1978)Bru-Pel and Brucella abortus lipopolysaccharide (LPS) were tested for both macrophage activation and antitumor activity in an artificial metastasis model. Resting macrophages were rendered nonspecifically tumoricidal for ...
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A monoclonal antibody against RAGE alters gene expression and is protective in experimental models of sepsis and pneumococcal pneumonia
(2011)The RAGE (receptor for advanced glycation end products) is believed to play a role in sepsis by perpetuating inflammation. The interaction of RAGE with a variety of host-derived ligands that accumulate during stress and ...
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Multiscale modelling of solid tumour growth: the effect of collagen micromechanics
(2016)Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. ...
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Multistage nanoparticle delivery system for deep penetration into tumor tissue
(2011)Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...
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Multistage nanoparticles for improved delivery into tumor tissue
(2012)The enhanced permeability and retention (EPR) effect has been a key rationale for the development of nanoscale carriers to solid tumors. As a consequence of EPR, nanotherapeutics are expected to improve drug and detection ...
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NK and NKT cell depletion alters the outcome of experimental pneumococcal pneumonia: Relationship with regulation of interferon- γ production
(2014)Background. Natural killer (NK) and natural killer T (NKT) cells contribute to the innate host defense but their role in bacterial sepsis remains controversial. Methods. C57BL/6 mice were infected intratracheally with 5 × ...
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Positive urinary cytology in patients with lung cancer in the absence of obvious urine tract metastases
(2011)Purpose: To study the phenomenon of positive urine cytology in patients with lung cancer in the absence of obvious urothelial metastases. Patients and methods: 150 patients with small (SCLC) and non-small cell lung cancer ...