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Browsing by Subject "Mitomycin c"

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    • Article  

      Cancer of unknown primary: Biological and clinical characteristics 

      Pavlidis, Nicholas (2003)

    • Article  

      Comparative survival with diverse chemotherapy regimens for cancer of unknown primary site: Multiple-treatments meta-analysis 

      Golfinopoulos, Vassilis; Pentheroudakis, George; Salanti, G.; Nearchou, A. D.; Ioannidis, J. P. A.; Pavlidis, Nicholas (2009)
      Objectives: To synthesize the evidence from randomized controlled trials concerning systemic treatment regimens for patients with cancer of unknown primary site (CUP). Data sources: PubMed and the Cochrane Library Central ...

    • Article  

      Diagnostic and therapeutic management of cancer of an unknown primary 

      Pavlidis, Nicholas; Briassoulis, E. Ch; Hainsworth, J.; Greco, F. A. (2003)
      Metastatic Cancer of Unknown Primary Site (CUP) accounts for approximately 3% of all malignant neoplasms and is therefore one of the 10 most frequent cancer diagnoses in man. Patients with CUP present with metastatic disease ...

    • Article  

      Effects of different chemotherapy regimens on survival for advanced cervical cancer: Systematic review and meta-analysis 

      Tzioras, S.; Pavlidis, Nicholas; Paraskevaidis, E.; Ioannidis, J. P. A. (2007)
      Background: A large number of trials have assessed various chemotherapy regimens for the treatment of advanced cervical cancer, but there is uncertainty about the magnitude of survival benefits. Methods: We searched (last ...

    • Article  

      ESMO minimum clinical recommendations for diagnosis, treatment and follow-up of invasive bladder cancer 

      Kataja, V. V.; Pavlidis, Nicholas (2005)

    • Article  

      Forty years experience of treating cancer of unknown primary 

      Pavlidis, Nicholas (2007)
      Cancer of unknown primary site (CUP) is not a rare tumour. It accounts as the seventh to eighth most frequently diagnosed cancer in a general medical oncology service. Since CUP is not a homogeneous disease and it consists ...

    • Article  

      Is the combination of 5-fluorouracil and folinic acid effective in advanced gastric carcinoma? Results of a pilot study and review of the literature 

      Pavlidis, Nicholas; Nikolaides, C.; Klouvas, G. D.; Briassoulis, E. Ch (1994)
      The main purpose of this trial was to investigate the activity of a less toxic regimen in patients with advanced gastric carcinoma regarding response rate and survival. We report on a pilot study of 20 patients treated ...

    • Article  

      Molecular assignment of tissue of origin in cancer of unknown primary may not predict response to therapy or outcome: A systematic literature review 

      Pentheroudakis, George; Greco, F. A.; Pavlidis, Nicholas (2009)
      Background: Gene expression profiling platforms were recently shown to accurately assign cancer of unknown primary (CUP) to a primary tissue of origin, with unknown impact on patient outcome. We examined chemotherapy ...

    • Article  

      No response or survival improvement in small cell lung cancer after sequential chemotherapy with three non-cross resistant drug regimens - a pilot study 

      Pavlidis, Nicholas; Ch, F. Tolis; Briassoulis, E. Ch; Sourla, A.; Klouvas, G. D. (1991)
      In a pilot phase II study we have treated 25 patients with small cell lung cancer by utilizing 3 non-cross resistant drug regimens given in a sequential fashion in combination with radiotherapy to the primary tumor. VAC ...

    • Article  

      Original article: Subsets of tumors responsive to cisplatin or carboplatin combinations in patients with carcinoma of unknown primary site: A hellenic cooperative oncology group study 

      Pavlidis, Nicholas; Kosmidis, Paraskevas A.; Skarlos, Dimosthenis V.; Briassoulis, E. Ch; Beer, M.; Theoharis, D.; Bafaloukos, Dimitrios; Maravegias, A.; Fountzilas, George (1992)
      Summary: In this retrospective analysis 48 patients with metastatic undifferentiated carcinoma, adenocarcinoma and epidermoid carcimona of unknown origin were studied. The purpose of this analysis was to evaluate both the ...

    • Article  

      Phase II study of irinotecan and mitomycin C in 5-fluorouracil-pretreated patients with advanced colorectal and gastric cancer 

      Bamias, A. T.; Papamichael, D.; Syrigos, K.; Pavlidis, Nicholas (2003)
      The aim of this phase II study was to investigate the tolerance and efficacy of a second-line irinotecan/ mitomycin C combination in patients with advanced gastric or colorectal cancer, pretreated with 5-fluorouracil. Forty ...

    • Article  

      Randomised trials comparing chemotherapy regimens for advanced non-small cell lung cancer: Biases and evolution over time 

      Ioannidis, J. P. A.; Polycarpou, A.; Ntais, C.; Pavlidis, Nicholas (2003)
      We systematically evaluated the evidence from randomised trials comparing various chemotherapy regimens for advanced non-small cell lung cancer. Across 254 eligible trials (42 661 patients), no regimens were compared in ...

    • Article  

      Rectal metastases from lobular carcinoma of the breast: Report of a case and literature review 

      Bamias, A. T.; Baltayiannis, G.; Kamina, S.; Fatouros, M.; Lymperopoulos, E.; Agnantis, Niki J.; Tsianos, Epameinondas; Pavlidis, Nicholas (2001)
      Metastatic involvement of the gastrointestinal (G1) tract secondary to breast cancer is rare. Reported herein is the case of a 74-year-old woman with metastatic lobular breast carcinoma to the rectum presenting with ...

    • Article  

      Survival and disease-progression benefits with treatment regimens for advanced colorectal cancer: a meta-analysis 

      Golfinopoulos, Vassilis; Salanti, G.; Pavlidis, Nicholas; Ioannidis, J. P. A. (2007)
      Background: Many randomised trials have compared different systemic treatment regimens in patients with advanced colorectal cancer. While survival advances have apparently been achieved, the magnitude of these incremental ...

    • Article  

      Systemic chemotherapy in gastric cancer: Where do we stand today? 

      Bamias, A. T.; Pavlidis, Nicholas (1998)
      Gastric cancer is one of the major causes of cancer-related mortality worldwide. Its prognosis is poor, and surgery offers the only realistic chance of cure. Nevertheless, most of the patients present with inoperable tumors, ...

    • Article  

      Treatment for Patients With Unknown Primary Carcinoma and Unfavorable Prognostic Factors 

      Greco, F. A.; Pavlidis, Nicholas (2009)
      The treatment for patients with unknown primary carcinoma, particularly those with unfavorable prognosis factors, has changed in the last decade, and continues to evolve. Empiric chemotherapy trials reported since 2000 ...

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