Browsing by Subject "Models"

Article

Aerial Oxidation of a VIV-Iminopyridine Hydroquinonate Complex: A Trap for the VIV-Semiquinonate Radical Intermediate

Stylianou, M.; Drouza, C.; Giapintzakis, John; Athanasopoulos, G. I.; Keramidas, A. D. (2015)

The reaction of 2,5-bis[N,N′-bis(2-pyridyl-aminomethyl)aminomethyl]-p-hydroquinone (H2bpymah) with VO2+ salts in acetonitrile or water at a low pH (2.2-3.5) results in the isolation of [VIV(O)(Cl)2(μ-bpymah)], the ...

Article

Antirestenotic effects of a novel polymer-coated d-24851 eluting stent. Experimental data in a rabbit iliac artery model

Lysitsas, Dimitrios N.; Katsouras, Christos S.; Papakostas, John C.; Toumpoulis, Ioannis K.; Angelidis, Charalampos; Bozidis, Petros; Thomas, Christopher G.; Seferiadis, C.; Psychoyios, Nikolaos; Frillingos, Stathis; Pavlidis, Nicholas; Marinos, Euaggelos; Khaldi, Lubna; Sideris, Dimitris A.; Michalis, Lampros K. (2007)

Experimental and clinical data suggest that stents eluting antiproliferative agents can be used for the prevention of in-stent restenosis. Here we investigate in vitro the antiproliferative and apoptotic effect of D-24851 ...

Article

Big events in Greece and HIV infection among people who inject drugs

Nikolopoulos, Georgios K.; Sypsa, V.; Bonovas, Stefanos; Paraskeva, D.; Malliori-Minerva, Melpomeni; Hatzakis, A.; Friedman, Samuel R. (2015)

Big Events are processes like macroeconomic transitions that have lowered social well-being in various settings in the past. Greece has been hit by the global crisis and experienced an HIV outbreak among people who inject ...

Article

Biphasic modeling of brain tumor biomechanics and response to radiation treatment

Angeli, S.; Stylianopoulos, T. (2016)

Biomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical ...

Article

Brownian-like kinematics of ball milling for particulate structural modeling

Doumanidis, C. C.; Kaabi, H. A. Al; Alzaabi, A. S. M.; Gunduz, I. E.; Rebholz, Claus; Doumanidis, C. C. (2016)

Ball milling motion has been previously studied through computationally expensive, off-line experimental video processing and numerical simulations by the discrete element method. This research establishes a more efficient ...

Article

Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model

Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (2013)

Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...

Article

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Jain, S. R.; Diop-Frimpong, B.; Bardeesy, N.; Smith, B. L.; Ferrone, C. R.; Hornicek, F. J.; Boucher, Y.; Munn, L. L.; Jain, R. K. (2012)

The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...

Article

Cell-nuclear data reduction and prognostic model selection in bladder tumor recurrence

Tasoulis, Dimitris K.; Spyridonos, Panagiota; Plagianakos, Vassilis P.; Ravazoula, Panagiota; Nikiforidis, Georgios; Vrahatis, Michael N. (2006)

OBJECTIVE: The paper aims at improving the prediction of superficial bladder recurrence. To this end, feedforward neural networks (FNNs) and a feature selection method based on unsupervised clustering, were employed. ...

Article

Coevolution of solid stress and interstitial fluid pressure in tumors during progression: Implications for vascular collapse

Stylianopoulos, T.; Martin, J. D.; Snuderl, M.; Mpekris, F.; Jain, S. R.; Jain, R. K. (2013)

The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or induced by the tumor itself due to its growth. Fluid pressure is ...

Article

Combining two strategies to improve perfusion and drug delivery in solid tumors

Stylianopoulos, T.; Jain, R. K. (2013)

Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a ...

Article

Computational predictions of the tensile properties of electrospun fibre meshes: Effect of fibre diameter and fibre orientation

Barocas, V. Η; Stylianopoulos, T.; Bashur, C. A.; Goldstein, A. S.; Guelcher, S. A. (2008)

The mechanical properties of biomaterial scaffolds are crucial for their efficacy in tissue engineering and regenerative medicine. At the microscopic scale, the scaffold must be sufficiently rigid to support cell adhesion, ...

Conference Object

Design and development of a haptic peg-board exercise for the rehabilitation of people with multiple sclerosis

Xydas, E. G.; Louca, Loucas S. (Affiliation: Mechanical and Manufacturing Engineering Department, University of Cyprus, P.O. Box: 20537, Nicosia, CyprusAffiliation: Mechanical and Manufacturing Engineering Department, University of CyprusCorrespondence Address: Xydas, E. G.Mechanical and Manufacturing Engineering Department, University of Cyprus, P.O. Box: 20537, Nicosia, Cyprusemail: mep4ex01@ucy.ac.cy, 2007)

Peg-in-Hole methods, like the Nine Hole Peg-Board Test (NHPT) and the Perdue board are widely employed for the functional assessment and therapy of the upper limbs of people with Multiple Sclerosis (MS). Such passive devices ...

Book Chapter

Development and test of an instrument that investigates teachers' beliefs, attitudes and intentions concerning the educational use of simulations

Zacharia, Zacharias C.; Rotsaka, Ioanna; Hovardas, Tasos (IAP Information Age Publishing, 2011)

The purpose of this research was to develop an instrument, namely, a questionnaire that investigates teachers' beliefs, attitudes, and intentions concerning the use of simulations for educational purposes, including for ...

Report

The Effects of Background Variables on the Participation of Students in Social Actions

Papanastasiou, Constantinos; Koutselini, Mary (2002)

This paper examines the extent to which home background and school climate affects ninth grade students' social and political understanding and participation. Using the data from the student questionnaires (n=3106) of the ...

Article

Evolution of osmotic pressure in solid tumors

Voutouri, C.; Stylianopoulos, T. (2014)

The mechanical microenvironment of solid tumors includes both fluid and solid stresses. These stresses play a crucial role in cancer progression and treatment and have been analyzed rigorously both mathematically and ...

Article

Explaining Differences in Subjective Well-Being Across 33 Nations Using Multilevel Models: Universal Personality, Cultural Relativity, and National Income

Cheng, Cecilia; Cheung, Mike W.-L.; Montasem, Alex; Panayiotou, Alexia (2016)

This multinational study simultaneously tested three prominent hypotheses–universal disposition, cultural relativity, and livability–that explained differences in subjective well-being across nations. We performed multilevel ...

Article

Fcγ receptor polymorphisms and their association with periodontal disease: A meta-analysis

Dimou, Niki L.; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J.; Bagos, Pantelis G. (2010)

Aim: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fcγ receptor (FcγR) polymorphisms with susceptibility to aggressive and chronic periodontal disease. Materials ...

Article

Generalized least squares for assessing trends in cumulative meta-analysis with applications in genetic epidemiology

Bagos, Pantelis G.; Nikolopoulos, Georgios K. (2009)

Objective: Cumulative meta-analysis allows the evaluation of a study's contribution to the combined effect of the preceding research. It accrues evidence, gradually adding studies one at a time and provides updated estimates ...

Article

Image-based biomechanics of collagen-based tissue equivalents

Barocas, V. Η; Sander, E.; Stylianopoulos, T.; Tranquillo, R. (2009)

Article

Image-based multiscale modeling predicts tissue-level and network-level fiber reorganization in stretched cell-compacted collagen gels

Barocas, V. Η; Sander, E. A.; Stylianopoulos, T.; Tranquillo, R. T. (2009)

The mechanical environment plays an important role in cell signaling and tissue homeostasis. Unraveling connections between externally applied loads and the cellular response is often confounded by extracellular matrix ...