Browsing by Subject "Models, Biological"

Article

Caspase-independent pathways of programmed cell death: The unraveling of new targets of cancer therapy?

Constantinou, Constantina; Papas, Konstantinos A.; Constantinou, Andreas I. (2009)

In the past few years, accumulating evidence in the literature supports the existence of pathways of caspase-independent programmed cell death (CI-PCD). These pathways are likely to be acting as 'death backup systems' that ...

Article

Commitment to erythroid differentiation in mouse erythroleukemia cells is controlled by alterations in topoisomerase IIα phosphorylation

Constantinou, Andreas I.; Vaughan, A. T. M.; Yamasaki, H.; Kamath, N. (1996)

To explore the program of cell differentiation in Friend murine erythroleukemia (MEL) cells, we used three clonal variants: phorbol 12- myristate 13-acetate (PMA)-hypersensitive TS-19-101, PMA-resistant TR19-9, and ...

Article

Computational sidechain placement and protein mutagenesis with implicit solvent models

Lopes, A.; Alexandrov, A.; Bathelt, C.; Archontis, Georgios Z.; Simonson, T. (2007)

Structure prediction and computational protein design should benefit from accurate solvent models. We have applied implicit solvent models to two problems that are central to this area. First, we performed sidechain placement ...

Article

Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis

Pitsouli, Chrysoula; Perrimon, N. (2010)

Adult structures in holometabolous insects such as Drosophila are generated by groups of imaginal cells dedicated to the formation of different organs. Imaginal cells are specified in the embryo and remain quiescent until ...

Article

The evolutionary consequences of interspecific aggression

Grether, G. F.; Anderson, Christopher N.; Drury, J. P.; Kirschel, A. N. G.; Losin, N.; Okamoto, K.; Peiman, K. S. (2013)

Competition has always been a cornerstone of evolutionary biology, and aggression is the predominant form of direct competition in animals, but the evolutionary effects of aggression between species are curiously understudied. ...

Article

Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes

Georgiades, Savvas N.; Mak, L. H.; Angurell, I.; Rosivatz, E.; Firouz Mohd Mustapa, M.; Polychroni, Christoulla; Woscholski, R.; Vilar, R. (2011)

The discovery of small-molecule modulators of signaling pathways is currently a particularly active area of research. We aimed at developing unprecedented metal-based activators of Akt signaling which can potentially find ...

Article

Interactions of hydroxycarbamide (Hydroxyurea) with Iron and copper: Implications on toxicity and therapeutic strategies

Konstantinou, E.; Pashalidis, Ioannis; Kolnagou, A.; Kontoghiorghes, G. J. (2011)

Presented at the 19th International Conference on Chelation, London, UK, 13-16 November 2009Preliminary spectrophotometric and potentiometric studies have shown that hydroxycarbamide or hydroxyurea (HU) can interact with ...

Article

Learning systems in biosignal analysis

Schizas, Christos N.; Pattichis, Constantinos S. (1997)

In biosignal analysis, the utility of artificial neural networks (ANN) in classifying electromyographic (EMG) data trained with the momentum back propagation algorithm has recently been demonstrated. In the current study, ...

Article

A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis

Erguler, K.; Pieri, Myrtani; Constantinou-Deltas, Constantinos D. (2013)

Background: The unfolded protein response (UPR) is a major signalling cascade acting in the quality control of protein folding in the endoplasmic reticulum (ER). The cascade is known to play an accessory role in a range ...

Article

Modeling the effects of toxins in metabolic networks

Tamaddoni-Nezhad, A.; Chaleil, R.; Kakas, Antonis C.; Sternberg, M.; Nicholson, J.; Muggleton, S. (2007)

Article

Pathogenesis of intestinal Pseudomonas aeruginosa infection in patients with cancer

Markou, P.; Apidianakis, Yiorgos (2014)

Article

The preparation and characterization of 5-substituted-4-chloro-1,2,3- dithiazolium salts and their conversion into 4-substituted-3-chloro-1,2,5- thiadiazoles

Koutentis, Panayiotis Andreas (2005)

A series of monosubstituted acetonitriles were treated with disulfur dichloride at room temperature in CH2Cl2 to afford 5-substituted-4-chloro-1,2,3-dithiazolium chlorides 1. Where the 5-substituent was not a good leaving ...

Article

Structural effects of crosslinking a biopolymer hydrogel derived from marine mussel adhesive protein

Loizou, Elena; Weisser, J. T.; Dundigalla, A.; Porcar, L.; Schmidt, G.; Wilker, J. J. (2006)

In an effort to explore new biocompatible substrates for biomedical technologies, we present a structural study on a crosslinked gelatinous protein extracted from marine mussels. Prior studies have shown the importance of ...

Article

Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors

Stylianopoulos, Triantafyllos; Economides, Eva Athena; Baish, J. W.; Fukumura, D.; Jain, R. K. (2015)

Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...

Article

Two ligand-binding sites in the O2-sensing signal transducer HemAT: Implications for ligand recognition/discrimination and signaling

Pinakoulaki, Eftychia; Yoshimura, H.; Daskalakis, Vangelis; Yoshioka, S.; Aono, S.; Varotsis, Constantinos (2006)

We have identified a ligand (CO) accommodation cavity in the signal transducer sensor protein HemAT (heme-based aerotactic transducer) that allows us to gain single-molecule insights into the mechanism of gas sensor proteins. ...