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Browsing by Subject "Morphine"

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    • Article  

      Analgesic tolerance and cross-tolerance to i.c.v. endomorphin-1, endomorphin-2, and morphine in mice; 15276249 

      Soignier, R. D.; Vaccarino, A. L.; Fanti, Kostas A.; Wilson, A. M.; Zadina, J. E. (2004)
      The present study examined the development of analgesic tolerance to endomorphin-1 (EM1), endomorphin-2 (EM2), and morphine, and cross-tolerance among these drugs. Male Swiss Webster mice were injected i.c.v. with EM1, ...

    • Article  

      Controlling cancer pain: Is morphine the best we can do? 

      Dietis, Nikolas; Rowbotham, D. J.; Lambert, D. G. (2011)
      Despite the existence of a family of 3 classical and one non-classical opioid receptor, morphine, acting at the MOP (μ) receptor remains the gold standard for use in cancer pain. The main thrust of opioid development has ...

    • Article  

      Morphine dosing strategy plays a key role in the generation and duration of the produced antinociceptive tolerance 

      Paul, A. K.; Gueven, Nuri; Dietis, Nikolas (2017)
      Antinociceptive tolerance after repetitive administration of morphine severely limits its clinical use. Despite increased mechanistic understanding of morphine tolerance, little is known about the influence of dosing ...

    • Article  

      Pharmacological characterization of the bifunctional opioid ligand H-Dmt-Tic-Gly-NH-Bzl (UFP-505) 

      Dietis, Nikolas; McDonald, J.; Molinari, S.; Calo, G.; Guerrini, R.; Rowbotham, D. J.; Lambert, D. G. (2012)
      BackgroundWhile producing good-quality analgesia,-opioid (MOP) receptor activation produces a number of side-effects including tolerance. Simultaneous blockade of δ-opioid (DOP) receptors has been shown to reduce tolerance ...

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