Browsing by Subject "Mortality"

Article

Age-Dependent Metastatic Spread and Survival: Cancer of Unknown Primary as a Model

Hemminki, K.; Pavlidis, Nicholas; Tsilidis, K. K.; Sundquist, K.; Ji, J. (2016)

In order to describe a novel approach for the clinical study of metastases, we provide here age-specific incidence and survival data for cancer of unknown primary (CUP). Metastases in various organs are found at CUP ...

Article

Alcohol and psychoactive drugs increased the pre-hospital mortality in 655 fall-related fatalities in Greece: A call for management protocols

Papadopoulos, I. N.; Bonovas, Stefanos; Kanakaris, Nikolaos K.; Nikolopoulos, Georgios K.; Kotsilianou, Olympia; Konstantoudakis, Georgios; Leukidis, Christos (2012)

Introduction: The frequency of alcohol and psychoactive drugs in fall-related fatalities and their effect on type, severity of injury and location of death constitute the subjects of this study. Methods: A retrospective ...

Article

Angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and circulating ACE levels are not associated with outcome in critically ill septic patients

Tsantes, Argirio E.; Tsangaris, I.; Kopterides, Petros; Nikolopoulos, Georgios K.; Kalamara, Eleni; Antonakos, Georgios; Kapsimali, Violetta; Gialeraki, Argiri; Dimopoulou, Ioanna; Orfanos, S.; Dima, Kleanthi; Travlou, Anthi S.; Armaganidis, Apostolos (2012)

Background: In critically ill patients independent studies have shown contradictory findings regarding the prognostic significance of the D/D genotype of the I/D angiotensin converting enzyme (ACE) polymorphism. The study ...

Article

Cancer of unknown primary during pregnancy: An exceptionally rare coexistence

Pavlidis, Nicholas; Peccatori, Fedro A.; Lofts, F.; Greco, F. A. (2015)

Background: Cancer in pregnancy is a rare disease with breast cancer, cervical cancer, melanoma and Hodgkin's disease to be the most commonly diagnosed malignancies during gestation. Cancer of unknown primary (CUP) is a ...

Article

Cancer prevalence and mortality in centenarians: A systematic review

Pavlidis, Nicholas; Stanta, G.; Audisio, R. A. (2012)

Life expectancy has dramatically expanded, the global population has aged unprecedentedly and the number of centenarians has significantly increased. The analysis of autopsy series, cancer registries data, vital statistics ...

Article

An ecological study of the determinants of differences in 2009 pandemic influenza mortality rates between countries in Europe

Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Lytras, Theodoros; Bonovas, Stefanos (2011)

Background: Pandemic A (H1N1) 2009 mortality rates varied widely from one country to another. Our aim was to identify potential socioeconomic determinants of pandemic mortality and explain between-country variation. ...

Article

Effect of angiotensin converting enzyme gene I/D polymorphism and its expression on clinical outcome in acute respiratory distress syndrome

Tsantes, Argirio E.; Kopterides, Petros; Bonovas, Stefanos; Bagos, Pantelis G.; Antonakos, Georgios; Nikolopoulos, Georgios K.; Gialeraki, Argiri; Kapsimali, Violetta; Kyriakou, Elias; Kokoris, Styliani; Dima, Kleanthi; Armaganidis, Apostolos; Tsangaris, I. (2013)

Background. The role of the D allele of the angiotensin-converting enzyme (ACE) gene I/D polymorphism in the clinical outcomes of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains ...

Article

The effect of homocysteine on the clinical outcomes of ventilated patients with severe sepsis

Tsantes, Argirio E.; Tsangaris, I.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Kopterides, Petros; Antonakos, Georgios; Dimopoulou, Ioanna; Vrioni, G.; Kapsimali, Violetta; Dima, Kleanthi; Armaganidis, Apostolos; Travlou, Anthi S. (2010)

Background. There is considerable evidence that elevated plasma homocysteine levels are associated with a prothrombotic milieu, whereas activation of the coagulation cascade is an important component of the pathogenesis ...

Article

The effect of plasma homocysteine levels on clinical outcomes of patients with acute lung injury/acute respiratory distress syndrome

Tsangaris, I.; Tsantes, Argirio E.; Bagos, Pantelis G.; Nikolopoulos, Georgios K.; Kroupis, C.; Kopterides, Petros; Dimopoulou, Ioanna; Orfanos, S.; Kardoulaki, A.; Chideriotis, S.; Travlou, Anthi S.; Armaganidis, Apostolos (2009)

Background: Several reports have shown that homocysteine promotes thrombosis by disturbing the procoagulant-anticoagulant balance, whereas alterations in coagulation and fibrinolysis have been suggested as important ...

Article

HBV-DNA levels predict overall mortality in HIV/HBV coinfected individuals

Nikolopoulos, Georgios K.; Paraskeva, D.; Psichogiou, M.; Hatzakis, A. (2016)

The coinfection of Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) has been associated with increased death rates. However, the relevant research has mostly relied on serologic HBV testing [HBV surface antigen ...

Conference Object

Heat related mortality in Cyprus under the A1B emissions scenario: Is additional air-conditioning an appropriate mitigation strategy?

Kouis, Panayiotis; Yiallouros, Panayiotis K.; Zachariades, T.; Papatheodorou, S. I. (Affiliation: Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus; Affiliation: Department of Environmental Science, Cyprus University of Technology, Limassol, Cyprus, 2016)

While climate change is expected to increase average temperatures around the globe as well as the number of atypically hot days and nights, several studies had identified an increase in heat-related mortality during hot ...

Article

High-burden epidemics in Greece in the era of economic crisis. Early signs of a public health tragedy

Bonovas, Stefanos; Nikolopoulos, Georgios K. (2012)

Background. Economic hardships have unleashed epidemics of infectious diseases in many countries in the past. In the era of the current financial crisis in Greece, it is interesting to assess the preliminary evidence ...

Article

HIV epidemiology in Greece

Nikolopoulos, Georgios K.; Paraskeva, D.; Hatzakis, A. (2008)

Greece has experienced early the effect of HIV/AIDS on morbidity and mortality. The era of highly active antiretroviral therapy has alleviated many of the consequences of the epidemic, however, HIV infection remains an ...

Article

Host immune response in sepsis due to ventilator-associated pneumonia: How is it different?

Christaki, Eirini (2009)

Current evidence regarding potentially different host response mechanisms in sepsis according to the type of initiating infection is sporadic. It is possible that alterations in cell populations, variations in effector ...

Article

Influenza vaccination: Cassandra's prophecy

Nikolopoulos, Georgios K.; Tsiodras, Sotirios; Bonovas, Stefanos (2012)

Article

Is the mortality rate for septic shock really decreasing?

Christaki, Eirini; Opal, Steven M. (2008)

Survival rates for patients in septic shock have gradually improved in critical care units worldwide over the last 25 years. Further improvement will be predicated on the discovery of new therapies to disrupt the underlying ...

Article

Metabolic syndrome and its components as predictors of all-cause mortality and coronary heart disease in type 2 diabetic patients

Protopsaltis, I. D.; Nikolopoulos, Georgios K.; Dimou, Eftihia; Brestas, Paris; Kokkoris, Stelios; Korantzopoulos, Panagiotis; Melidonis, Andreas (2007)

Background: There is no consistent evidence regarding the prognostic value of metabolic syndrome (MS) in predicting all-cause mortality and coronary heart disease (CHD) risk among type 2 diabetic patients. We sought to ...

Article

A monoclonal antibody against RAGE alters gene expression and is protective in experimental models of sepsis and pneumococcal pneumonia

Christaki, Eirini; Opal, Steven M.; Jr, James C. Keith; Kessimian, Nubar; Palardy, J. E.; Parejo, N. A.; Tan, X. Y.; Piche-Nicholas, N.; Tchistiakova, L.; Vlasuk, G. P.; Shields, K. M.; Feldman, Jeffrey L.; LaVallie, Edward R.; Arai, Maya; Mounts, W.; Pittman, D. D. (2011)

The RAGE (receptor for advanced glycation end products) is believed to play a role in sepsis by perpetuating inflammation. The interaction of RAGE with a variety of host-derived ligands that accumulate during stress and ...

Article

Motor vehicle collision fatalities involving alcohol and illicit drugs in Greece: The need for management protocols and a reassessment of surveillance

Papadopoulos, I. N.; Bonovas, Stefanos; Kanakaris, Nikolaos K.; Konstantiadou, Ioanna; Nikolopoulos, Georgios K.; Konstantoudakis, Georgios; Leukidis, Christos (2010)

Aims: The frequency and the effect of alcohol and illicit drugs on injury type, severity and location of death in motor vehicle collision (MVC) fatalities were investigated. Design: Retrospective case-control study based ...

Article

Neuroendocrine Merkel cell nodal carcinoma of unknown primary site: Management and outcomes of a rare entity

Kotteas, E. A.; Pavlidis, Nicholas (2015)

Merkel cell nodal carcinoma of unknown primary (MCCUP) is a rare neuroendocrine tumour with distinct clinical and biological behaviour. We conducted a review of retrospective data extracted from 90 patients focusing on the ...