Browsing by Subject "Neoplasm metastasis"

Article

Age-Dependent Metastatic Spread and Survival: Cancer of Unknown Primary as a Model

Hemminki, K.; Pavlidis, Nicholas; Tsilidis, K. K.; Sundquist, K.; Ji, J. (2016)

In order to describe a novel approach for the clinical study of metastases, we provide here age-specific incidence and survival data for cancer of unknown primary (CUP). Metastases in various organs are found at CUP ...

Article

Axillary nodal metastases from carcinoma of unknown primary (CUPAx): A systematic review of published evidence

Pentheroudakis, George; Lazaridis, G.; Pavlidis, Nicholas (2010)

Axillary lymph node metastases from adenocarcinoma or poorly differentiated carcinoma of unknown primary (CUPAx) represent a rare clinical entity without consensus on its biology, management and outcome. We systematically ...

Article

Cancer and pregnancy: Poena magna, not anymore

Pentheroudakis, George; Pavlidis, Nicholas (2006)

Cancer diagnosed during pregnancy constitutes a difficult clinical condition with a devastating impact on the patient's somatic and psychosocial health and possibly on foetal integrity. This circumstance also raises several ...

Article

Cancer of unknown primary (CUP)

Pavlidis, Nicholas; Fizazi, K. (2005)

Carcinoma of unknown primary (CUP) is one of the 10 most frequent cancers worldwide. It constitutes 3-5% of all human malignancies. Patients with CUP present with metastases without an established primary site. CUP manifests ...

Article

Clinicopathological study of the expression of syndecan-1 in invasive breast carcinomas. Correlation with extracellular matrix components

Tsanou, E.; Ioachim, E.; Briassoulis, E. Ch; Charchanti, A.; Damala, K.; Karavasilis, V.; Pavlidis, Nicholas; Agnantis, Niki J. (2004)

Syndecan-1, a cell surface proteoglycan found predominantly on epithelia of mature tissues, binds both extracellular matrix (ECM) components and basic fibroblast growth factor (bFGF) and is implicated in the restriction ...

Article

The diagnosis and management of gastric cancer: Expert discussion and recommendations from the 12th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2010

Cutsem, E. van; Dicato, M.; Geva, R.; Arber, N.; Bang, Y.; Benson, A.; Cervantes, A.; Diaz-Rubio, E.; Ducreux, M.; Glynne-Jones, R.; Grothey, Axel; Haller, D.; Haustermans, K.; Kerr, D.; Nordlinger, B.; Marshall, J.; Minsky, B. D.; Kang, Y. K.; Labianca, R.; Lordick, F.; Ohtsu, A.; Pavlidis, Nicholas; Roth, A.; Rougier, P.; Schmoll, H. J.; Sobrero, A.; Tabernero, Josep; Velde, C. van de; Zalcberg, J. (2011)

Well-recognized experts in the field of gastric cancer discussed during the 12th European Society Medical Oncology (ESMO)/World Congress Gastrointestinal Cancer (WCGIC) in Barcelona many important and controversial topics ...

Article

Dose-dense sequential chemotherapy with epirubicin and paclitaxel in advanced breast cancer

Razi, E. D.; Dimopoulos, M. A.; Bafaloukos, Dimitrios; Papadimitriou, C.; Kalogera-Fountzila, Anna; Kalofonos, H. P.; Briassoulis, E. Ch; Samantas, E.; Keramopoulos, A.; Pavlidis, Nicholas; Kosmidis, Paraskevas A.; Fountzilas, George (2001)

The purpose of this study was to evaluate the activity and toxicity profile of dose-dense sequential chemotherapy with epirubicin (EPI) and paclitaxel in advanced breast cancer (ABC). From January to September 1997, 41 ...

Article

Effect of maleic anhydride-divinyl ether copolymers on experimental M109 metastases and macrophage tumoricidal function

Pavlidis, Nicholas; Schultz, R. M.; Chirigos, M. A.; Luetzeler, J. (1978)

Pyran copolymer (NSC-46015) was compared with five maleic anhydride-divinyl ether copolymers (MVEs) of narrow molecular weight range both for the ability to render macrophages nonspecifically tumoricidal and to retard the ...

Article

Gemcitabine and vinorelbine as second-line treatment in patients with metastatic breast cancer progressing after first-line taxane-based chemotherapy: A phase II study conducted by the Hellenic Cooperative Oncology Group

Nikolaides, C.; Dimopoulos, M. A.; Samantas, E.; Bafaloukos, Dimitrios; Kalofonos, H. P.; Fountzilas, George; Razi, E. D.; Kosmidis, Paraskevas A.; Pavlidis, Nicholas (2000)

Background: Gemcitabine and vinorelbine have shown activity in breast cancer. A phase II trial was initiated in order to evaluate the response rate (RR) and time to progression (TTP) of the combination of the two drugs in ...

Article

Lung cancer in pregnancy: Report of nine cases from an international collaborative study

Boussios, Stergios; Han, S. N.; Fruscio, R.; Halaska, M. J.; Ottevanger, P. B.; Peccatori, Fedro A.; Koubková, L.; Pavlidis, Nicholas; Amant, F. (2013)

Objective: Lung cancer is an uncommon diagnosis during pregnancy. The combination of smoking in young women, increased maternal age during pregnancy, and increasing incidence of lung cancer worldwide may cause an increase ...

Article

Lung cancer in the pregnant woman: To treat or not to treat, that is the question

Jr, H. A. Azim; Peccatori, Fedro A.; Pavlidis, Nicholas (2010)

Lung cancer in pregnancy is a rare situation; however, it is increasingly reported in the past two decades. The association might be more encountered in the coming years due to the rising trends of cigarette smoking among ...

Article

Macrophage activation and antitumor activity of a Brucella abortus ether extract, Bru-Pel

Schultz, R. M.; Chirigos, M. A.; Pavlidis, Nicholas; Youngner, J. S. (1978)

Bru-Pel and Brucella abortus lipopolysaccharide (LPS) were tested for both macrophage activation and antitumor activity in an artificial metastasis model. Resting macrophages were rendered nonspecifically tumoricidal for ...

Article

Macrophage involvement in the antitumor activity of Brucella abortus ether extract against experimental lung carcinoma metastases

Schultz, R. M.; Pavlidis, Nicholas; Chirigos, M. A. (1978)

Article

Malignant melanoma of unknown primary site. To make the long story short. A systematic review of the literature

Kamposioras, K.; Pentheroudakis, George; Pectasides, Dimitrios; Pavlidis, Nicholas (2011)

Introduction: Although more than 90% of melanomas have a cutaneous origin, occasionally it is discovered as a secondary deposit without evident primary site. The aim of this study was to systematically review published ...

Article

Metastatic involvement of placenta and foetus in pregnant women with cancer.

Pavlidis, Nicholas; Pentheroudakis, George (2008)

Article

Molecular assignment of tissue of origin in cancer of unknown primary may not predict response to therapy or outcome: A systematic literature review

Pentheroudakis, George; Greco, F. A.; Pavlidis, Nicholas (2009)

Background: Gene expression profiling platforms were recently shown to accurately assign cancer of unknown primary (CUP) to a primary tissue of origin, with unknown impact on patient outcome. We examined chemotherapy ...

Article

Molecular markers and biological targeted therapies in metastatic colorectal cancer: expert opinion and recommendations derived from the 11th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2009.

Cutsem, E. Van; Dicato, M.; Arber, N.; Berlin, J.; Cervantes, A.; Ciardiello, F.; Gramont, A. De; Diaz-Rubio, E.; Ducreux, M.; Geva, R.; Glimelius, B.; Glynne-Jones, R.; Grothey, Axel; Gruenberger, T.; Haller, D.; Haustermans, K.; Labianca, R.; Lenz, H. J.; Minsky, B.; Nordlinger, B.; Ohtsu, A.; Pavlidis, Nicholas; Rougier, P.; Schmiegel, W.; Velde, C. Van de; Schmoll, H. J.; Sobrero, A.; Tabernero, Josep (2010)

The article summarizes the expert discussion and recommendations on the use of molecular markers and of biological targeted therapies in metastatic colorectal cancer (mCRC), as well as a proposed treatment decision strategy ...

Article

Oxaliplatin (eloxatin™) plus irinotecan combination chemotherapy found effective in refractory metastatic insular thyroid carcinoma

Briassoulis, E. Ch; Rontogianni, D.; Karavasilis, V.; Pavlidis, Nicholas (2005)

Therapeutic options for metastatic insular thyroid carcinoma (ITC) are very limited. We present the case of a 39-year-old woman with refractory metastatic ITC who responded to oxaliplatin plus irinotecan chemotherapy. She ...

Article

Paclitaxel in combination with carboplatin or gemcitabine for the treatment of advanced head and neck cancer

Fountzilas, George; Athanasiades, A.; Kalogera-Fountzila, Anna; Samantas, E.; Bacoyiannis, Charalambos; Briassoulis, E. Ch; Pavlidis, Nicholas; Kosmidis, Paraskevas A.; Skarlos, Dimosthenis V. (1997)

We performed a phase II study to evaluate the activity and toxicity of the combination of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) and carboplatin as first-line treatment in patients with recurrent ...

Article

Paclitaxel-carboplatin combination chemotherapy in advanced breast cancer: Accumulating evidence for synergy, efficacy, and safety

Pentheroudakis, George; Razi, E. D.; Athanasiades, A.; Pavlidis, Nicholas; Fountzilas, George (2006)

Patients with metastatic breast cancer receive multiple lines of cytotoxic chemotherapy, with taxane and anthracycline-based regimens being the most active. Anthracyclines carry the risk of significant cardiotoxicity at ...