• Article  

      Analgesic tolerance and cross-tolerance to i.c.v. endomorphin-1, endomorphin-2, and morphine in mice; 15276249 

      Soignier, R. D.; Vaccarino, A. L.; Fanti, Kostas A.; Wilson, A. M.; Zadina, J. E. (2004)
      The present study examined the development of analgesic tolerance to endomorphin-1 (EM1), endomorphin-2 (EM2), and morphine, and cross-tolerance among these drugs. Male Swiss Webster mice were injected i.c.v. with EM1, ...
    • Article  

      Cancer and pregnancy: A comprehensive review 

      Voulgaris, E.; Pentheroudakis, George; Pavlidis, Nicholas (2011)
      Background: Pregnancy complicated by cancer is relatively rare but, as women in western societies tend to delay childbearing to the third and fourth decade of life, this phenomenon is going to be encountered more often in ...
    • Article  

      Cancer and pregnancy: Poena magna, not anymore 

      Pentheroudakis, George; Pavlidis, Nicholas (2006)
      Cancer diagnosed during pregnancy constitutes a difficult clinical condition with a devastating impact on the patient's somatic and psychosocial health and possibly on foetal integrity. This circumstance also raises several ...
    • Article  

      Cancer, fertility and pregnancy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up 

      Pentheroudakis, George; Orecchia, R.; Hoekstra, H. J.; Pavlidis, Nicholas (2010)
    • Article  

      Cefditoren: Comparative efficacy with other antimicrobials and risk factors for resistance in clinical isolates causing UTIs in outpatients 

      Hatzaki, Despina; Poulakou, G.; Katsarolis, Ioannis; Lambri, Niki; Souli, M.; Deliolanis, Ioannis; Nikolopoulos, Georgios K.; Lebessi, Evangelia; Giamarellou, Helen (2012)
      Background: To investigate a possible role of Cefditoren, a recently marketed in Greece third-generation oral cephalosporin in urinary infections of outpatients.Methods: During a multicenter survey of Enterobacteriaceae ...
    • Article  

      The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host 

      Christaki, Eirini; Giamarellos-Bourboulis, Evangelos J. (2014)
      Bacteremia develops when bacteria manage to escape the host immune mechanisms or when the otherwise well-orchestrated immune response fails to control bacterial spread due to inherent or acquired immune defects that are ...
    • Article  

      Depression in cancer: The many biobehavioral pathways driving tumor progression 

      Bortolato, B.; Hyphantis, T.; Valpione, S.; Perini, G.; Maes, M.; Morris, G.; Kubera, M.; Köhler, C. A.; Fernandes, B. S.; Stubbs, B.; Pavlidis, Nicholas; Carvalho, A. F. (2017)
      Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased ...
    • Article  

      Economic recession and emergence of an HIV-1 outbreak among drug injectors in Athens metropolitan area: A longitudinal study 

      Paraskeva, D.; Nikolopoulos, Georgios K.; Fotiou, Anastasios; Tsiara, Chrissa G.; Paraskeva, D.; Sypsa, V.; Lazanas, Marios; Gargalianos, Panagiotis; Psichogiou, M.; Skoutelis, A.; Wiessing, L.; Friedman, Samuel R.; Jarlais, Don C. Des; Terzidou, M.; Kremastinou, Jenny; Malliori-Minerva, Melpomeni; Hatzakis, A. (2013)
      Background: During 2011, a dramatic increase (1600%) of reported HIV-1 infections among injecting drug users (IDUs) was noted in Athens, Greece. We herein assess the potential causal pathways associated with this outbreak. ...
    • Article  

      Enhanced HIV-1 surveillance using molecular epidemiology to study and monitor HIV-1 outbreaks among intravenous drug users (IDUs) in Athens and Bucharest 

      Paraskeva, D.; Paraschiv, S.; Sypsa, V.; Nikolopoulos, Georgios K.; Tsiara, Chrissa G.; Magiorkinis, Gkikas; Psichogiou, M.; Flampouris, Andreas; Mardarescu, Mariana; Niculescu, I.; Batan, Ionelia; Malliori-Minerva, Melpomeni; Otelea, D.; Hatzakis, A. (2015)
      Background: A significant increase in HIV-1 diagnoses was reported among Injecting Drug Users (IDUs) in the Athens (17-fold) and Bucharest (9-fold) metropolitan areas starting 2011. Methods: Molecular analyses were conducted ...
    • Article  

      Estimating HIV incidence and number of undiagnosed individuals living with HIV in the European union/ European economic area, 2015 

      Pharris, Anastasia; Quinten, C.; Noori, T.; Amato-Gauci, A. J.; Sighem, A. van; Schmid, D.; Rueckerl, I.; Zangerle, R.; Sasse, A.; Beckhoven, D. van; Denauw, F.; Varleva, T.; Georgieva, V.; Blazic, T. N.; Pavlic, J.; Begovac, J.; Koliou, M.; Hadjihannas, L.; Demetriou, A.; Maly, M.; Šikolová, V.; Cowan, Susan; Fouchard, J.; Rüütel, K.; Pääsukene, A. L.; Liitsola, K.; Salminen, M.; Brummer-Korvenkontio, H.; Cazein, F.; Pillonel, J.; Lot, F.; Comboroure, J.-C.; Gunsenheimer-Bartmeyer, Barbara; Heiden, M. A. Der; Kupfer, G.; Marcus, U.; Nikolopoulos, Georgios K.; Paraskeva, D.; Konte, Vasileia; Dudas, M.; Szalay, K.; Briem, H.; Sigmundsdottir, G.; Igoe, D.; O’Donnell, K.; Hurley, C.; Lyons, F.; Suligoi, B.; Caraglia, A.; Konova, S.; Erne, S.; Caplinskiene, I.; Fischer, A.; Hoffmann, P.; Melillo, J. M.; Melillo, T.; Coul, Eline Op de; David, S.; Blystad, H.; Myrberg, A. J.; Rosinska, M.; Wawer, I.; Mansinho, K.; Martins, H. C.; Melillo, T.; Mardarescu, Mariana; Truska, P.; Mikas, J.; Klavs, I.; Diaz, Alejandro; Nuñez, O.; Castillo, O.; Avdicova, Maria; Sonnerborg, A.; Kirwan, P.; Chau, C.; Okala, S.; Brown, A.; Delpech, Valerie (2016)
      Since 2011, human immunodeficiency virus (HIV) incidence appears unchanged in the European Union/ European Economic Area with between 29,000 and 33,000 new cases reported annually up to 2015. Despite evidence that HIV ...
    • Article  

      Estrogen receptor β agonism increases survival in experimentally induced sepsis and ameliorates the genomic sepsis signature: A pharmacogenomic study 

      Christaki, Eirini; Opal, Steven M.; Jr, James C. Keith; Kessimian, Nubar; Palardy, J. E.; Parejo, N. A.; LaVallie, Edward R.; Racie, L.; Mounts, W.; Malamas, Michael S.; Mewshaw, Richard E.; Harris, Heather A.; Vlasuk, G. P. (2010)
      Background. Nonsteroidal agonists have been developed that selectively bind to and activate estrogen receptor β (ERβ) rather than estrogen receptor α (ERα). ERβ is expressed equally in both male and female mammals in ...
    • Article  

      HIV-1 outbreak among injecting drug users in Greece, 2011: A preliminary report 

      Paraskeva, D.; Nikolopoulos, Georgios K.; Tsiara, Chrissa G.; Paraskeva, D.; Antoniadou, Anastasia; Lazanas, Marios; Gargalianos, Panagiotis; Psychogiou, M.; Malliori-Minerva, Melpomeni; Kremastinou, Jenny; Hatzakis, A. (2011)
      A significant increase (more than 10-fold) in the number of newly diagnosed HIV-1 infections among injecting drug users (IDUs) was observed in Greece during the first seven months of 2011. Molecular epidemiology results ...
    • Article  

      Immunomodulatory therapy for sepsis: An update 

      Christaki, Eirini; Anyfanti, Panagiota; Opal, Steven M. (2011)
      Currently the treatment mainstay of sepsis is early and appropriate antibiotic therapy, accompanied by aggressive fluid administration, the use of vasopressors when needed and the prompt initiation of measures to support ...
    • Article  

      Impact of hepatitis B virus infection on the progression of AIDS and mortality in HIV-infected individuals: A cohort study and meta-analysis 

      Nikolopoulos, Georgios K.; Paraskeva, D.; Hatzitheodorou, E.; Moschidis, Zissis; Sypsa, V.; Zavitsanos, X.; Kalapothaki, Victoria; Hatzakis, A. (2009)
      Background. The effect of hepatitis B virus (HBV) infection on the natural history of human immunodeficiency virus (HIV) disease remains uncertain. Therefore, a retrospective cohort study was conducted to examine the ...
    • Article  

      The kinetics of T regulatory cells in shock: Beyond sepsis 

      Christaki, Eirini; Patrozou, E. (2010)
      During the past decade, there have been an increasing number of studies investigating the precise role of T regulatory cells in human disease. First recognized for their ability to prevent autoimmunity, T regulatory cells ...
    • Article  

      A monoclonal antibody against RAGE alters gene expression and is protective in experimental models of sepsis and pneumococcal pneumonia 

      Christaki, Eirini; Opal, Steven M.; Jr, James C. Keith; Kessimian, Nubar; Palardy, J. E.; Parejo, N. A.; Tan, X. Y.; Piche-Nicholas, N.; Tchistiakova, L.; Vlasuk, G. P.; Shields, K. M.; Feldman, Jeffrey L.; LaVallie, Edward R.; Arai, Maya; Mounts, W.; Pittman, D. D. (2011)
      The RAGE (receptor for advanced glycation end products) is believed to play a role in sepsis by perpetuating inflammation. The interaction of RAGE with a variety of host-derived ligands that accumulate during stress and ...
    • Article  

      New technologies in predicting, preventing and controlling emerging infectious diseases 

      Christaki, Eirini (2015)
      Surveillance of emerging infectious diseases is vital for the early identification of public health threats. Emergence of novel infections is linked to human factors such as population density, travel and trade and ecological ...
    • Article  

      NK and NKT cell depletion alters the outcome of experimental pneumococcal pneumonia: Relationship with regulation of interferon- γ production 

      Christaki, Eirini; Diza, Evdoxia; Giamarellos-Bourboulis, Evangelos J.; Papadopoulou, Nikoletta; Pistiki, Aikaterini; Droggiti, Dionysia-Irini; Georgitsi, Marianna; Machova, Alzbeta; Lambrelli, Dimitra; Malisiovas, Nicolaos; Nikolaidis, Pavlos; Opal, Steven M. (2014)
      Background. Natural killer (NK) and natural killer T (NKT) cells contribute to the innate host defense but their role in bacterial sepsis remains controversial. Methods. C57BL/6 mice were infected intratracheally with 5 × ...
    • Article  

      Paclitaxel-carboplatin combination chemotherapy in advanced breast cancer: Accumulating evidence for synergy, efficacy, and safety 

      Pentheroudakis, George; Razi, E. D.; Athanasiades, A.; Pavlidis, Nicholas; Fountzilas, George (2006)
      Patients with metastatic breast cancer receive multiple lines of cytotoxic chemotherapy, with taxane and anthracycline-based regimens being the most active. Anthracyclines carry the risk of significant cardiotoxicity at ...
    • Article  

      Positive urinary cytology in patients with lung cancer in the absence of obvious urine tract metastases 

      Voulgaris, E.; Pentheroudakis, George; Pappa, L.; Bafa, M.; Goussia, Anna; Dalezis, P.; Tsombanidou, C.; Geromichalos, G.; Papageorgiou, A.; Koutsilieris, M.; Malamou-Mitsi, Vassiliki D.; Pavlidis, Nicholas (2011)
      Purpose: To study the phenomenon of positive urine cytology in patients with lung cancer in the absence of obvious urothelial metastases. Patients and methods: 150 patients with small (SCLC) and non-small cell lung cancer ...