Browsing by Subject "Odds ratio"

Article

Association between the plasminogen activator inhibitor-1 4G/5G polymorphism and venous thrombosis

Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Rapti, E.; Mantzios, Georgios P.; Kapsimali, Violetta; Travlou, Anthi S. (2007)

The effect of the 675 insertion/deletion (4G/5G) polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene on the risk of venous thromboembolism (VTE) remains controversial. In this study, we performed a meta-analysis ...

Article

Efficacy and safety of more intensive lowering of LDL cholesterol [1]

Bonovas, Stefanos; Nikolopoulos, Georgios K.; Sitaras, N. M. (2011)

Article

Evaluation of the prognostic role of centromere 17 gain and HER2/topoisomerase II alpha gene status and protein expression in patients with breast cancer treated with anthracycline-containing adjuvant chemotherapy: Pooled analysis of two Hellenic Cooperative Oncology Group (HeCOG) phase III trials

Fountzilas, George; Dafni, U.; Bobos, M.; Kotoula, V.; Batistatou, Anna; Xanthakis, I.; Papadimitriou, C.; Kostopoulos, I.; Koletsa, T.; Tsolaki, E.; Televantou, D.; Timotheadou, E.; Koutras, A. K.; Klouvas, G. D.; Samantas, E.; Pisanidis, N.; Karanikiotis, C.; Sfakianaki, I.; Pavlidis, Nicholas; Gogas, H.; Linardou, H.; Kalogeras, K. T.; Pectasides, Dimitrios; Dimopoulos, M. A. (2013)

Background: The HER2 gene has been established as a valid biological marker for the treatment of breast cancer patients with trastuzumab and probably other agents, such as paclitaxel and anthracyclines. The TOP2A gene has ...

Article

Fcγ receptor polymorphisms and their association with periodontal disease: A meta-analysis

Dimou, Niki L.; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J.; Bagos, Pantelis G. (2010)

Aim: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fcγ receptor (FcγR) polymorphisms with susceptibility to aggressive and chronic periodontal disease. Materials ...

Article

The GNB3 C825T polymorphism and essential hypertension: A meta-analysis of 34 studies including 14 094 cases and 17 760 controls

Bagos, Pantelis G.; Elefsinioti, Antigoni L.; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J. (2007)

OBJECTIVES: The C825T single nucleotide polymorphism of the G-protein β3 (GNB3) has been implicated in susceptibility to essential hypertension, through the expression of an alternatively spliced truncated variant. In an ...

Article

Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: A meta-analysis

Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Vaiopoulos, G.; Travlou, Anthi S. (2007)

Background: The platelet-collagen receptor, glycoprotein (GP) la/lla plays a crucial role in the adhesion of platelets to fibrillar collagen, an event contributing to the pathogenesis of thrombosis. The C807T polymorphism ...

Article

Multiple-treatments meta-analysis of chemotherapy and targeted therapies in advanced breast cancer

Mauri, D.; Polyzos, N. P.; Salanti, G.; Pavlidis, Nicholas; Ioannidis, J. P. A. (2008)

Background: Many systemic nonhormonal regimens have been evaluated across several hundreds of randomized trials in advanced breast cancer. We aimed to quantify the relative merits of these regimens in prolonging survival. ...

Article

Neoadjuvant versus adjuvant systemic treatment in breast cancer: A meta-analysis

Mauri, D.; Pavlidis, Nicholas; Ioannidis, J. P. A. (2005)

Background: Interest in the use of preoperative systemic treatment in the management of breast cancer has increased because such neoadjuvant therapy appears to reduce the extent of local surgery required. We compared the ...

Article

Phase II study of irinotecan and mitomycin C in 5-fluorouracil-pretreated patients with advanced colorectal and gastric cancer

Bamias, A. T.; Papamichael, D.; Syrigos, K.; Pavlidis, Nicholas (2003)

The aim of this phase II study was to investigate the tolerance and efficacy of a second-line irinotecan/ mitomycin C combination in patients with advanced gastric or colorectal cancer, pretreated with 5-fluorouracil. Forty ...

Article

Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: Meta-analysis

Mauri, D.; Pavlidis, Nicholas; Polyzos, N. P.; Ioannidis, J. P. A. (2006)

Background: Aromatase inhibitors and inactivators have been extensively tested in patients with advanced breast cancer, but it is unclear whether they offer any survival benefits compared with standard hormonal treatment ...