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Browsing by Subject "P53"

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    • Article  

      Bcl2 and p53 protein expression in metastatic carcinoma of unknown primary origin: Biological and clinical implications. A Hellenic co-operative oncology group study 

      Briassoulis, E. Ch; Tsokos, M.; Fountzilas, George; Bafaloukos, Dimitrios; Kosmidis, Paraskevas A.; Samantas, E.; Skarlos, Dimosthenis V.; Nikolaides, C.; Pavlidis, Nicholas (1998)
      We have previously shown that metastatic carcinomas of unknown primary site overexpress several tumor markers as well as the products of the oncogenes c-myc, ras and c-erbB2. We analysed the tissue expression of the protein ...

    • Article  

      Clinicopathological study of the expression of hsp27, pS2, cathepsin D and metallothionein in primary invasive breast cancer 

      Ioachim, E.; Tsanou, E.; Briassoulis, E. Ch; Batsis, Ch; Karavasilis, V.; Charchanti, A.; Pavlidis, Nicholas; Agnantis, Niki J. (2003)
      Expression of the hormone-related proteins hsp27, pS2, and also of cathepsin D (CD) and metallothionein (MT) was studied by immunohistochemistry and analyzed against clinical data in breast cancer. Archived material of ...

    • Article  

      Genistein inactivates bcl-2, delays the G2/M phase of the cell cycle, and induces apoptosis of human breast adenocarcinoma MCF-7 cells 

      Constantinou, Andreas I.; Kamath, N.; Murley, J. S. (1998)
      The aim of this study was to identify the molecular mechanism of action of the isoflavone, genistein. Genistein at 0.15 mM caused MCF-7 apoptotic cell death, which was accompanied by cell cycle delay in the G2/M phase. ...

    • Article  

      p53/MDM-2 immunohistochemical expression correlated with proliferative activity in different subtypes of human sarcomas: A ten-year follow-up study 

      Stefanou, D. G.; Nonni, A. V.; Agnantis, Niki J.; Athanasiadou, S. E.; Briassoulis, E. Ch; Pavlidis, Nicholas (1998)
      The aim of this study was the evaluation of p53/MDM-2 protein overexpression in different subtypes of human sarcomas, and their correlation with proliferative activity and patient outcome. We selected 40 cases of human ...

    • Article  

      The prognostic evaluation of tumor angiogenesis in invasive breast carcinoma 

      Ioachim, E.; Charchanti, A.; Charalabopoulos, K.; Tsanou, E.; Briassoulis, E. Ch; Karavasilis, V.; Pavlidis, Nicholas; Agnantis, Niki J. (2002)
      Microvessel density (MVD) was analyzed for associations with clinical and pathological factors as well as with other potential known prognostic factors such as: steroid receptor content (ER, PgR), p53 and proliferation ...

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