Browsing by Subject "Phase ii trial"
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Article
Multicentre phase II pharmacological evaluation of rhizoxin
(1996)Rhizoxin is a macrocyclic lactone compound that binds to tubulin and inhibits microtubule assembly. Rhizoxin demonstrated preclinical anti-tumour activity against a variety of human tumour cell lines and xenograft models. ...
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Article
Phase II clinical trials with rhizoxin in breast cancer and melanoma
(1996)Rhizoxin is a new anti-tumour agent isolated from the pathogenic fungus Rhizopus chinensis. It has shown broad activity against murine tumour models and is also active against vinca alkaloid-resistant cells. The purpose ...