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Browsing by Subject "Plant Extracts"

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    • Article  

      Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: Bioassay-directed isolation and characterization of active principles 

      Burdette, J. E.; Chen, S. -N; Lu, Z. -Z; Xu, H.; White, B. E. P.; Fabricant, D. S.; Liu, J.; Fong, H. H. S.; Farnsworth, N. R.; Constantinou, Andreas I.; Van Breemen, R. B.; Pezzuto, J. M.; Bolton, J. L. (2002)
      The roots/rhizomes of Cimicifuga racemosa L. (Nutt.) (black cohosh) have traditionally been used to treat menopausal symptoms through an unknown mechanism of action. In an effort to determine if black cohosh had additional ...

    • Article  

      Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms 

      Liu, J.; Burdette, J. E.; Xu, H.; Gu, C.; Van Breemen, R. B.; Bhat, K. P. L.; Booth, N.; Constantinou, Andreas I.; Pezzuto, J. M.; Fong, H. H. S.; Farnsworth, N. R.; Bolton, J. L. (2001)
      Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red clover (Trifolium pratense L.), chasteberry (Vitex agnus-castus ...

    • Article  

      Hydrophilic olive cake extracts: Characterization by physicochemical properties and Cu(II) complexation 

      Kolokassidou, K.; Szymczak, W.; Wolf, M.; Obermeier, C.; Buckau, G.; Pashalidis, Ioannis (2009)
      Disposed olive cake generates hydrophilic components that can be mobilized in the aquatic environment. This paper deals with the characterization of such components, isolated by alkaline extraction. It is shown that these ...

    • Article  

      Identification of the factors responsible for the in vitro pro-oxidant and cytotoxic activities of the olive polyphenols oleuropein and hydroxytyrosol 

      Odiatou, Elena M.; Skaltsounis, Alexios Leandros; Constantinou, Andreas I. (2013)
      The olive polyphenols oleuropein and hydroxytyrosol were reported recently to produce extracellular hydrogen peroxide (H2O2) under standard culture conditions. The precise factors responsible for this production and the ...

    • Article  

      In vitro antioxidant activity and phenolic content of Cedrus brevifolia bark 

      Cretu, E.; Salminen, J. -P; Karonen, M.; Miron, A.; Charalambous, Christina; Constantinou, Andreas I.; Aprotosoaie, A. C. (2014)
      A raw extract and four extractive fractions were obtained from Cedrus brevifolia (Cyprus cedar) bark. They were all studied regarding the phenolic content and profile using spectrophotometry and HPLC-DAD-ESI-MS. The ...

    • Article  

      In vitro study on the antioxidant activity of a polyphenol-rich extract from pinus brutia bark and its fractions 

      Cretu, E.; Karonen, M.; Salminen, J. -P; Mircea, C.; Trifan, A.; Charalambous, Christina; Constantinou, Andreas I.; Miron, A. (2013)
      A crude hydromethanolic extract from Pinus brutia bark and its fractions (diethyl ether, ethyl acetate, n-butanol, and aqueous fractions) were studied with regard to their phenolic content and antioxidant activities. The ...

    • Article  

      Induction of caspase-independent programmed cell death by vitamin E natural homologs and synthetic derivatives. 

      Constantinou, Constantina; Hyatt, John Anthony; Vraka, Panayiota S.; Papas, Andreas M.; Papas, Konstantinos A.; Neophytou, Christiana M.; Hadjivassiliou, V.; Constantinou, Andreas I. (2009)
      Current observations in the literature suggest that vitamin E may be a suitable candidate for cancer chemotherapy. To investigate this further, we examined the ability of the vitamin E natural homologs [alpha-, beta-, ...

    • Article  

      A preliminary RAPD-PCR analysis of Cimicifuga species and other botanicals used for women's health 

      Xu, H.; Fabricant, D. S.; Piersen, C. E.; Bolton, J. L.; Pezzuto, J. M.; Fong, H.; Totura, S.; Farnsworth, N. R.; Constantinou, Andreas I. (2002)
      Traditional taxonomic methods of botanical identification that rely primarily on morphological observations cannot be used efficiently when only powdered plant materials are available. Thus, our objectives were to determine ...

    • Article  

      Structure-activity relationships of brassinin in preventing the development of carcinogen-induced mammary lesions in organ culture 

      Mehta, R. G.; Liu, J.; Constantinou, Andreas I.; Hawthorne, M.; Pezzuto, J. M.; Moon, R. C.; Moriarty, R. M. (1994)
      Brassinin, a pkytoalexin, is found in Chinese cabbage. Previously, we showed that brassinin significantly inhibited dimethylbenz(a)anthracene (DMBA)-induced mammary lesions in organ culture. Moreover, it was an effective ...

    • Article  

      Studies on the interaction of olive cake and its hydrophylic extracts with polyvalent metal ions (Cu(II), Eu(III)) in aqueous solutions 

      Konstantinou, M.; Kolokassidou, K.; Pashalidis, Ioannis (2009)
      The paper presents and discusses the chemical affinity of two different forms of natural organic matter (e.g. in solid (SOM) and soluble form (DOM)) for Cu2+ and Eu3+ ions. In the this study SOM is represented by olive ...

    • Article  

      Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized sprague-dawley rats 

      Burdette, J. E.; Liu, J.; Lantvit, D.; Lim, E.; Booth, N.; Bhat, K. P. L.; Hedayat, S.; Van Breemen, R. B.; Constantinou, Andreas I.; Pezzuto, J. M.; Farnsworth, N. R.; Bolton, J. L. (2002)
      Studies were conducted using an ovariectomized rat model to determine the estrogenic and antiestrogenic activity of Trifolium pratense L. (red clover) extracts. A red clover extract, standardized to contain 15% isoflavones ...

    • Article  

      Vernonia kotschyana roots: Therapeutic potential via antioxidant activity 

      Vasincu, A.; Paulsen, B. S.; Diallo, D.; Vasincu, I.; Aprotosoaie, A. C.; Bild, V.; Charalambous, Christina; Constantinou, Andreas I.; Miron, A.; Gavrilescu, C. M. (2014)
      The roots of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae) are used in Malian traditional medicine in the treatment of gastroduodenal ulcers and gastritis. Since oxidative stress is involved in gastric ulceration, ...

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