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Browsing by Subject "Polymerase chain reaction"

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    • Article  

      Association of ERCC1 SNPs with outcome in platinum-treated patients with advanced urothelial cancer: A Hellenic Cooperative Oncology Group study 

      Nikitas, N.; Karadimou, A.; Tsitoura, E.; Soupos, N.; Tsiatas, M.; Karavasilis, V.; Pectasides, Dimitrios; Pavlidis, Nicholas; Chrisofos, M.; Adamakis, I.; Murray, S.; Fountzilas, George; Dimopoulos, M. A.; Bamias, A. T. (2012)
      Aim: The association between two polymorphisms of ERCC1 and treatment outcomes after platinum-based chemotherapy in patients with advanced urothelial cancer (UC) was examined. Materials & methods: Genotyping of 19007C>T ...

    • Article  

      Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: Interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes 

      Pentheroudakis, George; Kotoula, V.; Roock, W. De; Kouvatseas, G.; Papakostas, P.; Makatsoris, T.; Papamichael, D.; Xanthakis, I.; Sgouros, J.; Televantou, D.; Kafiri, G.; Tsamandas, A. C.; Razi, E. D.; Galani, E.; Bafaloukos, Dimitrios; Efstratiou, I.; Bompolaki, I.; Pectasides, Dimitrios; Pavlidis, Nicholas; Tejpar, S.; Fountzilas, George (2013)
      Background: More than half of patients with KRAS-wild type advanced colorectal cancer (CRC) fail anti-EGFR monoclonal antibodies. We studied EGFR-axis messenger RNA (mRNA) expression and RAS, RAF, PIK3CA mutations in order ...

    • Article  

      Global profiling of EGFR gene mutation, amplification, regulation and tissue protein expression in unknown primary carcinomas: To target or not to target? 

      Dova, L.; Pentheroudakis, George; Georgiou, I.; Malamou-Mitsi, Vassiliki D.; Vartholomatos, G.; Fountzilas, George; Kolaitis, N.; Kitsou, E.; Pavlidis, Nicholas (2007)
      Introduction: Epidermal growth factor receptor (EGFR) signalling contributes to malignant transformation and survival. We studied molecular predictors of benefit from EGFR-modulating therapies in patients with cancer of ...

    • Article  

      Greek Cypriot allele and genotype frequencies for amplitype® PM-DQA1 and D1S80 loci 

      Cariolou, Marios A.; Manoli, Panayiotis; Christoforou, Maria; Bashiardes, Evy; Karagrigoriou, Alex; Budowle, Bruce (1998)
      A sample from the Greek Cypriot population was typed at seven forensically important PCR-based loci: LDLR, GYPA, HBGG, D7S8, GC, HLA-DQA1, and D1S80. The results showed that all loci meet Hardy-Weinberg expectations and ...

    • Article  

      High Throughput Analysis of Integron Gene Cassettes in Wastewater Environments 

      Gatica, Joao; Tripathi, Vijay; Green, Stefan; Manaia, C. M.; Berendonk, Thomas U.; Cacace, Damiano; Merlin, Christophe; Kreuzinger, Norbert; Schwartz, Thomas; Fatta-Kassinos, Despo; Rizzo, Luigi; Schwermer, Carsten U.; Garelick, Hemda; Jurkevitch, Edouard; Cytryn, Eddie (2016)
      Integrons are extensively targeted as a proxy for anthropogenic impact in the environment. We developed a novel high-throughput amplicon sequencing pipeline that enables characterization of thousands of integron gene ...

    • Article  

      KRAS, NRAS and BRAF mutations in Greek and Romanian patients with colorectal cancer: A cohort study 

      Negru, S.; Papadopoulou, E.; Apessos, A.; Stanculeanu, D. L.; Ciuleanu, E.; Volovat, C.; Croitoru, A.; Kakolyris, S.; Aravantinos, Gerasimos; Ziras, N.; Athanasiadis, E.; Touroutoglou, N.; Pavlidis, Nicholas; Kalofonos, H. P.; Nasioulas, G. (2014)
      Objectives: Treatment decision-making in colorectal cancer is often guided by tumour tissue molecular analysis. The aim of this study was the development and validation of a high-resolution melting (HRM) method for the ...

    • Article  

      Serous papillary peritoneal carcinoma: Unknown primary tumour, ovarian cancer counterpart or a distinct entity? A systematic review 

      Pentheroudakis, George; Pavlidis, Nicholas (2010)
      Introduction: Serous peritoneal papillary carcinoma (SPPC), though managed according to ovarian cancer therapeutic principles, has been variably considered as an ovarian cancer counterpart, a peritoneal malignancy with ...

    • Article  

      Survivin and glycodelin transcriptional activity in node-positive early breast cancer: mRNA expression of two key regulators of cell survival 

      Kostadima, Lida; Pentheroudakis, George; Fountzilas, George; Dimopoulos, M. A.; Pectasides, Dimitrios; Gogas, H.; Christodoulou, C.; Samantas, E.; Bafaloukos, Dimitrios; Arapantoni, P.; Kalofonos, H. P.; Papakostas, P.; Economopoulos, T.; Bamias, A. T.; Pavlidis, Nicholas; Stropp, U.; Wirtz, R. M.; Hennig, G. (2006)
      Introduction: Glycodelin and survivin are key polypeptide regulators of cellular proliferation, apoptosis and angiogenesis. In view of contradictory reports on their functional role in tumors, we studied their transcriptional ...

    • Article  

      Systemic dissemination in cancer of unknown primary is independent of mutational inactivation of the KiSS-1 metastasis-suppressor gene 

      Dova, L.; Golfinopoulos, Vassilis; Pentheroudakis, George; Georgiou, I.; Pavlidis, Nicholas (2008)
      Cancer of unknown primary represents a heterogeneous group of malignancies characterised by early systemic dissemination and lack of primary site. KiSS1 is a member of the metastasis-suppressor gene family whose functional ...

    • Article  

      Targeting c-KIT, PDGFR in cancer of unknown primary: A screening study for molecular markers of benefit 

      Dova, L.; Pentheroudakis, George; Golfinopoulos, Vassilis; Malamou-Mitsi, Vassiliki D.; Georgiou, I.; Vartholomatos, G.; Ntemou, A.; Fountzilas, George; Pavlidis, Nicholas (2008)
      Aims: In view of available targeted therapies, we investigated the presence of c-kit, PDGFR gene mutations and protein expression in cancer of unknown primary (CUP) in order to study their contribution in pathogenesis, ...

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