Browsing by Subject "Protein Kinase C"

Now showing items 1-2 of 2

Article

Novobiocin- and Phorbol-12-myristate-13-acetate-induced Differentiation of Human Leukemia Cells Associated with a Reduction in Topoisomerase II Activity

Constantinou, Andreas I.; Henning-Chubb, C.; Huberman, E. (1989)

Studies were conducted to determine the possible involvement of DNA topoisomerase II (Topo II) in the induction of differentiation in two human promyelocytic HL-60 leukemia cell variants that are either susceptible or ...
Article

Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylasetissue plasminogen activator-mediated thrombolysis

Gerhäuser, C.; Mar, W.; Lee, S. K.; Suh, N.; Luo, Y.; Kosmeder, J.; Luyengi, L.; Fong, H. H. S.; Kinghorn, A. D.; Moriarty, R. M.; Mehta, R. G.; Constantinou, Andreas I.; Moon, R. C.; Pezzuto, J. M. (1995)

For the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were ...