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Browsing by Subject "Protein expression"

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    • Article  

      Angiogenesis in cancer of unknown primary: Clinicopathological study of CD34, VEGF and TSP-1 

      Karavasilis, V.; Malamou-Mitsi, Vassiliki D.; Briassoulis, E. Ch; Tsanou, E.; Kitsou, E.; Kalofonos, H. P.; Fountzilas, George; Fotsis, T.; Pavlidis, Nicholas (2005)
      Background: Cancer of unknown primary remains a mallignancy of elusive biology and grim prognosis that lacks effective therapeutic options. We investigated angiogenesis in cancer of unknown primary to expand our knowledge ...

    • Article  

      Axillary nodal metastases from carcinoma of unknown primary (CUPAx): A systematic review of published evidence 

      Pentheroudakis, George; Lazaridis, G.; Pavlidis, Nicholas (2010)
      Axillary lymph node metastases from adenocarcinoma or poorly differentiated carcinoma of unknown primary (CUPAx) represent a rare clinical entity without consensus on its biology, management and outcome. We systematically ...

    • Article  

      Bcl2 and p53 protein expression in metastatic carcinoma of unknown primary origin: Biological and clinical implications. A Hellenic co-operative oncology group study 

      Briassoulis, E. Ch; Tsokos, M.; Fountzilas, George; Bafaloukos, Dimitrios; Kosmidis, Paraskevas A.; Samantas, E.; Skarlos, Dimosthenis V.; Nikolaides, C.; Pavlidis, Nicholas (1998)
      We have previously shown that metastatic carcinomas of unknown primary site overexpress several tumor markers as well as the products of the oncogenes c-myc, ras and c-erbB2. We analysed the tissue expression of the protein ...

    • Article  

      Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: Interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes 

      Pentheroudakis, George; Kotoula, V.; Roock, W. De; Kouvatseas, G.; Papakostas, P.; Makatsoris, T.; Papamichael, D.; Xanthakis, I.; Sgouros, J.; Televantou, D.; Kafiri, G.; Tsamandas, A. C.; Razi, E. D.; Galani, E.; Bafaloukos, Dimitrios; Efstratiou, I.; Bompolaki, I.; Pectasides, Dimitrios; Pavlidis, Nicholas; Tejpar, S.; Fountzilas, George (2013)
      Background: More than half of patients with KRAS-wild type advanced colorectal cancer (CRC) fail anti-EGFR monoclonal antibodies. We studied EGFR-axis messenger RNA (mRNA) expression and RAS, RAF, PIK3CA mutations in order ...

    • Article  

      Cancer of unknown primary site: Missing primary or missing biology? 

      Pentheroudakis, George; Briassoulis, E. Ch; Pavlidis, Nicholas (2007)
      Cancer of unknown primary site (CUP) ranks as the fourth most common cause of cancer deaths and represents both a diagnostic and a management challenge. In CUP, the regression or dormancy of the primary tumor, the development ...

    • Article  

      The clinical significance of bcl-2 overexpression in breast cancer patients - A retrospective study with long term follow up 

      Bai, M. C.; Agnantis, Niki J.; Zagorianakou, P.; Kamina, S.; Nonni, A. V.; Pavlidis, Nicholas; Briassoulis, E. Ch (2001)
      We examined by immunohistochemistry the expression of the bcl-2 protein in sixty-eight cases of operated breast carcinoma patients (stage I, II and III) and correlated the findings with the prognosis. In 38.3% of the cases ...

    • Article  

      Clinicopathologic study of vascular endothelial growth factor, thrombospondin-1, and microvessel density assessed by CD34 in patients with stage III ovarian carcinoma 

      Karavasilis, V.; Malamou-Mitsi, Vassiliki D.; Briassoulis, E. Ch; Tsanou, E.; Kitsou, E.; Pavlidis, Nicholas (2006)
      The aim of the study was to investigate angiogenesis in patients with advanced-stage ovarian carcinoma. We used paraffin-embedded tumor tissues from 33 patients diagnosed with FIGO III ovarian cancer who had optimal surgery ...

    • Article  

      Clinicopathological study of metallothionein immunohistochemical expression, in benign, borderline and malignant ovarian epithelial tumors 

      Zagorianakou, N.; Stefanou, D. G.; Makrydimas, G.; Zagorianakou, P.; Briassoulis, E. Ch; Karavasilis, V.; Pavlidis, Nicholas; Agnantis, Niki J. (2006)
      Metallothioneins (MTs) are a family of cystein-rich metal-binding proteins, which are expressed in normal cells during fetal and postnatal life but also in a variety of human neoplasms. MT expression in human tumors has ...

    • Article  

      Clinicopathological study of the expression of hsp27, pS2, cathepsin D and metallothionein in primary invasive breast cancer 

      Ioachim, E.; Tsanou, E.; Briassoulis, E. Ch; Batsis, Ch; Karavasilis, V.; Charchanti, A.; Pavlidis, Nicholas; Agnantis, Niki J. (2003)
      Expression of the hormone-related proteins hsp27, pS2, and also of cathepsin D (CD) and metallothionein (MT) was studied by immunohistochemistry and analyzed against clinical data in breast cancer. Archived material of ...

    • Article  

      Clinicopathological study of the expression of syndecan-1 in invasive breast carcinomas. Correlation with extracellular matrix components 

      Tsanou, E.; Ioachim, E.; Briassoulis, E. Ch; Charchanti, A.; Damala, K.; Karavasilis, V.; Pavlidis, Nicholas; Agnantis, Niki J. (2004)
      Syndecan-1, a cell surface proteoglycan found predominantly on epithelia of mature tissues, binds both extracellular matrix (ECM) components and basic fibroblast growth factor (bFGF) and is implicated in the restriction ...

    • Article  

      DCC and TS protein expression in resected gastric cancer: A Hellenic Cooperative Oncology Group Study 

      Bamias, A. T.; Fountzilas, George; Michael, M. C.; Konstantaras, C.; Vrettou, E.; Eleftheriadis, E.; Papakostas, P.; Papadimitriou, K.; Pavlidis, Nicholas; Xiros, N.; Bai, M. C. (2008)
      There is a high risk of relapse after resection of gastric cancer. We studied the prognostic significance of the deleted colorectal cancer (DCC) gene and thymidylate synthase (TS) protein expression after resection of ...

    • Article  

      Depression in cancer: The many biobehavioral pathways driving tumor progression 

      Bortolato, B.; Hyphantis, T.; Valpione, S.; Perini, G.; Maes, M.; Morris, G.; Kubera, M.; Köhler, C. A.; Fernandes, B. S.; Stubbs, B.; Pavlidis, Nicholas; Carvalho, A. F. (2017)
      Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased ...

    • Article  

      The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risk 

      Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Bonovas, Stefanos; Kopterides, Petros; Vaiopoulos, G. (2008)
      Plasminogen activator inhibitor (PAI-1), is the central component of the fibrinolytic system. A deletion/insertion (4G/5G) polymorphism in the promoter region of the PAI-1 gene has been correlated with levels of plasma ...

    • Article  

      Evaluation of the prognostic role of centromere 17 gain and HER2/topoisomerase II alpha gene status and protein expression in patients with breast cancer treated with anthracycline-containing adjuvant chemotherapy: Pooled analysis of two Hellenic Cooperative Oncology Group (HeCOG) phase III trials 

      Fountzilas, George; Dafni, U.; Bobos, M.; Kotoula, V.; Batistatou, Anna; Xanthakis, I.; Papadimitriou, C.; Kostopoulos, I.; Koletsa, T.; Tsolaki, E.; Televantou, D.; Timotheadou, E.; Koutras, A. K.; Klouvas, G. D.; Samantas, E.; Pisanidis, N.; Karanikiotis, C.; Sfakianaki, I.; Pavlidis, Nicholas; Gogas, H.; Linardou, H.; Kalogeras, K. T.; Pectasides, Dimitrios; Dimopoulos, M. A. (2013)
      Background: The HER2 gene has been established as a valid biological marker for the treatment of breast cancer patients with trastuzumab and probably other agents, such as paclitaxel and anthracyclines. The TOP2A gene has ...

    • Article  

      Exploring the biology of cancer of unknown primary: Breakthroughs and drawbacks 

      Kamposioras, K.; Pentheroudakis, George; Pavlidis, Nicholas (2013)
      Background: Cancer of unknown primary (CUP) ranks among the ten most common malignancies worldwide. Cancer of unknown primary presents as disseminated disease, has a dismal prognosis and remains a diagnosis of exclusion. ...

    • Article  

      Expression of E-cadherin in primary endometrial carcinomas: Clinicopathological and immunohistochemical analysis of 30 cases 

      Varras, M.; Skafida, E.; Vasilakaki, T.; Anastasiadis, A.; Akrivis, C.; Vrachnis, N.; Nikolopoulos, Georgios K. (2013)
      Introduction: Decreased expression of E-cadherin has been associated with poorly differentiated endometrial carcinomas and poorer outcomes. Aim: The purpose of this study was to examine the distribution of E-cadherin ...

    • Article  

      Gastrointestinal stromal tumors during pregnancy: a systematic review of an uncommon but treatable malignancy 

      Zarkavelis, George; Petrakis, Dimitrios; Pavlidis, Nicholas (2015)
      Although modern social structure and medical advances have led to the increasing number of women childbearing in older age, cancer remains a rare diagnosis during pregnancy. There is little given information throughout the ...

    • Article  

      Global microRNA profiling in favorable prognosis subgroups of cancer of unknown primary (CUP) demonstrates no significant expression differences with metastases of matched known primary tumors 

      Pentheroudakis, George; Spector, Y.; Krikelis, D.; Kotoula, V.; Meiri, E.; Malamou-Mitsi, Vassiliki D.; Fountzilas, George; Sanden, M.; Pavlidis, Nicholas; Benjamin, H.; Aharonov, R. (2013)
      No data exist on biologic differences between Cancer of unknown primary (CUP) and metastatic solid tumors of known primary site. We assigned a primary tissue of origin in 40 favorable CUP patients (A: serous peritoneal ...

    • Article  

      Global profiling of EGFR gene mutation, amplification, regulation and tissue protein expression in unknown primary carcinomas: To target or not to target? 

      Dova, L.; Pentheroudakis, George; Georgiou, I.; Malamou-Mitsi, Vassiliki D.; Vartholomatos, G.; Fountzilas, George; Kolaitis, N.; Kitsou, E.; Pavlidis, Nicholas (2007)
      Introduction: Epidermal growth factor receptor (EGFR) signalling contributes to malignant transformation and survival. We studied molecular predictors of benefit from EGFR-modulating therapies in patients with cancer of ...

    • Article  

      High levels of topoisomerase IIα protein expression in diffuse large B-cell lymphoma are associated with high proliferation, germinal center immunophenotype, and response to treatment 

      Pentheroudakis, George; Goussia, Anna; Voulgaris, E.; Nikolaides, C.; Ioannidou, E.; Papoudou-Bai, A.; Grepi, K.; Kanavaros, P.; Pavlidis, Nicholas; Bai, M. C. (2010)
      Gene copy number and protein expression of topoisomerase IIα were correlated to benefit from anthracyclines in various tumors. A retrospective series of 69 patients with DLBCL managed with CHOP chemotherapy were studied ...

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