Browsing by Subject "Pseudomonas aeruginosa"
Now showing items 1-20 of 23
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Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer
(2004)Azurin, a copper-containing redox protein released by the pathogenic bacterium Pseudomonas aeruginosa, is highly cytotoxic to the human breast cancer cell line MCF-7, but is less cytotoxic toward p53-negative (MDA-MB-157) ...
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The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies
(2014)Bacteria contaminate insects and secrete metabolites that may affect insect behaviour and potentially fitness through unknown mechanisms. Here we show that the 'grape-like' odorant 2-aminoacetophenone (2AA), secreted by ...
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Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection
(2012)Patients with severe burns are highly susceptible to bacterial infection. While immunosuppression facilitates infection, the contribution of soft tissues to infection beyond providing a portal for bacterial entry remains ...
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Drosophila melanogaster as a model for human intestinal infection and pathology
(2011)Recent findings concerning Drosophila melanogaster intestinal pathology suggest that this model is well suited for the study of intestinal stem cell physiology during aging, stress and infection. Despite the physiological ...
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Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection
(2009)Conservation of host signaling pathways and tissue physiology between Drosophila melanogaster and mammals allows for the modeling of human host-pathogen interactions in Drosophila. Here we present the use of genetically ...
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Drosophila melanogaster: A first step and a stepping-stone to anti-infectives
(2013)Following an expansion in the antibiotic drug discovery in the previous century, we now face a bottleneck in the production of new anti-infective drugs. Traditionally, chemical libraries are screened either using in vitro ...
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Doctoral Thesis
Ecological and biological responses to environmental changes, in the endemic scleractinian coral, Cladocora caespitosa (Linnaeus, 1767), in Cyprus
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2019-10)Η παρούσα διατριβή διερευνά τις οικολογικές και βιολογικές αποκρίσεις του μεσογειακού κοραλλιού Cladocora caespitosa, σε περιβαλλοντικές αλλαγές. Το σκληρακτήνιο αυτό είδος κοραλλιού, το οποίο χτίζει αποικίες, έχει ανομοιότυπη ...
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Evaluation of novel, cationic electrospun microfibrous membranes as adsorbents in bacteria removal
(2015)Electrospun microfibrous membranes comprised of poly(methyl methacrylate)-poly((2-diethylamino)ethyl methacrylate) random copolymers (PMMA-co-PDEAEMA) of various chemical compositions blended together with a commercially ...
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Evaluation of novel, cationic electrospun microfibrous membranes as adsorbents in bacteria removal
(2015)Electrospun microfibrous membranes comprised of poly(methyl methacrylate)-poly((2-diethylamino)ethyl methacrylate) random copolymers (PMMA-co-PDEAEMA) of various chemical compositions blended together with a commercially ...
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Homeostatic interplay between bacterial cell-cell signaling and iron in virulence
(2010)Pathogenic bacteria use interconnected multi-layered regulatory networks, such as quorum sensing (QS) networks to sense and respond to environmental cues and external and internal bacterial cell signals, and thereby adapt ...
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Human pathogenic bacteria, fungi, and viruses in Drosophila
(2014)Drosophila has been the invertebrate model organism of choice for the study of innate immune responses during the past few decades. Many Drosophila-microbe interaction studies have helped to define innate immunity pathways, ...
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Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells
(2012)Although pathogenic bacteria are suspected contributors to colorectal cancer progression, cancer-promoting bacteria and their mode of action remain largely unknown. Here we report that sustained infection with the human ...
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Doctoral Thesis
Investigating the role of pseudomonas aeruginosa metabolism in virulence
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2019-12)Η τρέχουσα παγκόσμια τάση αντοχής στα αντιβιοτικά απαιτεί νέες προσεγγίσεις για αντιμολυσματική θεραπεία. Η ψευδομονάδα (Pseudomonas aeruginosa), είναι ένα Gram-αρνητικό βακτήριο που ταξινομείται μεταξύ των παθογόνων πρώτης ...
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Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma
(2007)Despite recent advances in our understanding the pathophysiology of trauma, the basis of the predisposition of trauma patients to infection remains unclear. A Drosophila melanogaster/Pseudomonas aeruginosa injury and ...
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The pathogenic properties of a novel and conserved gene product, KerV, in proteobacteria
(2009)Identification of novel virulence factors is essential for understanding bacterial pathogenesis and designing antibacterial strategies. In this study, we uncover such a factor, termed KerV, in Proteobacteria. Experiments ...
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Post-cataract surgery endophthalmitis outbreak caused by multidrug-resistant Pseudomonas aeruginosa
(2012)In June 2010, a severe outbreak of 13 cases of postcataract surgery endophthalmitis caused by multidrug-resistant Pseudomonas aeruginosa occurred. Pulse-field gel electrophoresis in eye isolates found 95% genetic similarity; ...
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Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimocrobial peptide gene expression
(2005)Insights into the host factors and mechanisms mediating the primary host responses after pathogen presentation remain limited, due in part to the complexity and genetic intractability of host systems. Here, we employ the ...
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Doctoral Thesis
Pseudomonas aeruginosa interactions with its host and with commensal escherichia coli
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2018–10)Το ανθρώπινο μικροβίωμα αποτελείται από μικροοργανισμούς που φιλοξενούνται σε διάφορα μέρη του ανθρώπινου σώματος. Περιοχές που έρχονται σε επαφή με το περιβάλλον ή με την καταναλωθέντα τροφή όπως, το δέρμα, το αναπνευστικό ...