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Browsing by Subject "Pseudomonas aeruginosa"

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    • Article  

      Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer 

      Punj, V.; Bhattacharyya, S.; Saint-Dic, D.; Vasu, C.; Cunningham, E. A.; Graves, J.; Yamada, T.; Constantinou, Andreas I.; Christov, K.; White, B.; Li, G.; Majumdar, D.; Chakrabarty, A. M.; Das Gupta, T. K. (2004)
      Azurin, a copper-containing redox protein released by the pathogenic bacterium Pseudomonas aeruginosa, is highly cytotoxic to the human breast cancer cell line MCF-7, but is less cytotoxic toward p53-negative (MDA-MB-157) ...

    • Article  

      The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies 

      Kapsetaki, Stefania Elisavet; Tzelepis, Ilias; Avgousti, Kalodoti; Livadaras, Ioannis; Garantonakis, Nikos G.; Varikou, Kyriaki N.; Apidianakis, Yiorgos (2014)
      Bacteria contaminate insects and secrete metabolites that may affect insect behaviour and potentially fitness through unknown mechanisms. Here we show that the 'grape-like' odorant 2-aminoacetophenone (2AA), secreted by ...

    • Article  

      Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection 

      Apidianakis, Yiorgos; Que, Y. -A; Xu, W.; Tegos, G. P.; Zimniak, P.; Hamblin, M. R.; Tompkins, R. G.; Xiao, W.; Rahme, L. G. (2012)
      Patients with severe burns are highly susceptible to bacterial infection. While immunosuppression facilitates infection, the contribution of soft tissues to infection beyond providing a portal for bacterial entry remains ...

    • Article  

      Drosophila melanogaster as a model for human intestinal infection and pathology 

      Apidianakis, Yiorgos; Rahme, L. G. (2011)
      Recent findings concerning Drosophila melanogaster intestinal pathology suggest that this model is well suited for the study of intestinal stem cell physiology during aging, stress and infection. Despite the physiological ...

    • Article  

      Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection 

      Apidianakis, Yiorgos; Rahme, L. G. (2009)
      Conservation of host signaling pathways and tissue physiology between Drosophila melanogaster and mammals allows for the modeling of human host-pathogen interactions in Drosophila. Here we present the use of genetically ...

    • Article  

      Drosophila melanogaster: A first step and a stepping-stone to anti-infectives 

      Tzelepis, Ilias; Kapsetaki, Stefania Elisavet; Panayidou, S.; Apidianakis, Yiorgos (2013)
      Following an expansion in the antibiotic drug discovery in the previous century, we now face a bottleneck in the production of new anti-infective drugs. Traditionally, chemical libraries are screened either using in vitro ...

    • Doctoral Thesis  

      Ecological and biological responses to environmental changes, in the endemic scleractinian coral, Cladocora caespitosa (Linnaeus, 1767), in Cyprus 

      Hadjioannou, Louis M. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2019-10)
      Η παρούσα διατριβή διερευνά τις οικολογικές και βιολογικές αποκρίσεις του μεσογειακού κοραλλιού Cladocora caespitosa, σε περιβαλλοντικές αλλαγές. Το σκληρακτήνιο αυτό είδος κοραλλιού, το οποίο χτίζει αποικίες, έχει ανομοιότυπη ...

    • Article  

      Evaluation of novel, cationic electrospun microfibrous membranes as adsorbents in bacteria removal 

      Papaphilippou, Petri Ch; Vyrides, Ioannis; Mpekris, Fotios; Stylianopoulos, Triantafyllos; Papatryfonos, Charalambos A.; Theocharis, Charis R.; Krasia‐Christoforou, Theodora (2015)
      Electrospun microfibrous membranes comprised of poly(methyl methacrylate)-poly((2-diethylamino)ethyl methacrylate) random copolymers (PMMA-co-PDEAEMA) of various chemical compositions blended together with a commercially ...

    • Article  

      Evaluation of novel, cationic electrospun microfibrous membranes as adsorbents in bacteria removal 

      Papaphilippou, P.; Vyrides, I.; Mpekris, F.; Stylianopoulos, T.; Papatryfonos, C. A.; Theocharis, C. R.; Krasia-Christoforou, T. (2015)
      Electrospun microfibrous membranes comprised of poly(methyl methacrylate)-poly((2-diethylamino)ethyl methacrylate) random copolymers (PMMA-co-PDEAEMA) of various chemical compositions blended together with a commercially ...

    • Article  

      Homeostatic interplay between bacterial cell-cell signaling and iron in virulence 

      Hazan, R.; He, J.; Xiao, G.; Dekimpe, V.; Apidianakis, Yiorgos; Lesic, B.; Astrakas, C.; Déziel, Eric; Lépine, F.; Rahme, L. G. (2010)
      Pathogenic bacteria use interconnected multi-layered regulatory networks, such as quorum sensing (QS) networks to sense and respond to environmental cues and external and internal bacterial cell signals, and thereby adapt ...

    • Article  

      Human pathogenic bacteria, fungi, and viruses in Drosophila 

      Panayidou, S.; Ioannidou, E.; Apidianakis, Yiorgos (2014)
      Drosophila has been the invertebrate model organism of choice for the study of innate immune responses during the past few decades. Many Drosophila-microbe interaction studies have helped to define innate immunity pathways, ...

    • Article  

      Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells 

      Bangi, E.; Pitsouli, Chrysoula; Rahme, L. G.; Cagan, R.; Apidianakis, Yiorgos (2012)
      Although pathogenic bacteria are suspected contributors to colorectal cancer progression, cancer-promoting bacteria and their mode of action remain largely unknown. Here we report that sustained infection with the human ...

    • Doctoral Thesis  

      Investigating the role of pseudomonas aeruginosa metabolism in virulence 

      Panayidou, Stavria P. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2019-12)
      Η τρέχουσα παγκόσμια τάση αντοχής στα αντιβιοτικά απαιτεί νέες προσεγγίσεις για αντιμολυσματική θεραπεία. Η ψευδομονάδα (Pseudomonas aeruginosa), είναι ένα Gram-αρνητικό βακτήριο που ταξινομείται μεταξύ των παθογόνων πρώτης ...

    • Article  

      Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma 

      Apidianakis, Yiorgos; Mindrinos, M. N.; Xiao, W.; Tegos, G. P.; Papisov, M. I.; Hamblin, M. R.; Davis, R. W.; Tompkins, R. G.; Rahme, L. G. (2007)
      Despite recent advances in our understanding the pathophysiology of trauma, the basis of the predisposition of trauma patients to infection remains unclear. A Drosophila melanogaster/Pseudomonas aeruginosa injury and ...

    • Article  

      Modeling hologenome imbalances in inflammation and cancer 

      Apidianakis, Yiorgos; Ferrandon, D. (2014)

    • Article  

      Pathogenesis of intestinal Pseudomonas aeruginosa infection in patients with cancer 

      Markou, P.; Apidianakis, Yiorgos (2014)

    • Article  

      The pathogenic properties of a novel and conserved gene product, KerV, in proteobacteria 

      An, D.; Apidianakis, Yiorgos; Boechat, A. L.; Baldini, R. L.; Goumnerov, B. C.; Rahme, L. G. (2009)
      Identification of novel virulence factors is essential for understanding bacterial pathogenesis and designing antibacterial strategies. In this study, we uncover such a factor, termed KerV, in Proteobacteria. Experiments ...

    • Article  

      Post-cataract surgery endophthalmitis outbreak caused by multidrug-resistant Pseudomonas aeruginosa 

      Maltezou, Helena C.; Pappa, O.; Nikolopoulos, Georgios K.; Ftika, L.; Maragos, Antonios; Kaitsa, H.; Protonotariou, E.; Diza, Evdoxia; Georgiadis, N.; Vatopoulos, A.; Nikolaidis, Pavlos (2012)
      In June 2010, a severe outbreak of 13 cases of postcataract surgery endophthalmitis caused by multidrug-resistant Pseudomonas aeruginosa occurred. Pulse-field gel electrophoresis in eye isolates found 95% genetic similarity; ...

    • Article  

      Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimocrobial peptide gene expression 

      Apidianakis, Yiorgos; Mindrinos, M. N.; Xiao, W.; Lau, G. W.; Baldini, R. L.; Davis, R. W.; Rahme, L. G. (2005)
      Insights into the host factors and mechanisms mediating the primary host responses after pathogen presentation remain limited, due in part to the complexity and genetic intractability of host systems. Here, we employ the ...

    • Doctoral Thesis  

      Pseudomonas aeruginosa interactions with its host and with commensal escherichia coli 

      Christofi, Theodoulakis Ch. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2018–10)
      Το ανθρώπινο μικροβίωμα αποτελείται από μικροοργανισμούς που φιλοξενούνται σε διάφορα μέρη του ανθρώπινου σώματος. Περιοχές που έρχονται σε επαφή με το περιβάλλον ή με την καταναλωθέντα τροφή όπως, το δέρμα, το αναπνευστικό ...

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