Browsing by Subject "Randomized controlled trial (topic)"

Article

The beginning of personalized medicine in sepsis: Small steps to a bright future

Christaki, Eirini; Giamarellos-Bourboulis, Evangelos J. (2014)

There is a growing recognition that there is a need for a more personalized approach towards sepsis care. In most clinical trials investigating novel therapeutic interventions against sepsis, patients have been considered ...

Article

The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host

Christaki, Eirini; Giamarellos-Bourboulis, Evangelos J. (2014)

Bacteremia develops when bacteria manage to escape the host immune mechanisms or when the otherwise well-orchestrated immune response fails to control bacterial spread due to inherent or acquired immune defects that are ...

Article

Developing the evidence base for cancer chemoprevention: Use of meta-analysis

Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Bonovas, Stefanos (2011)

Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. It answers a specific research question, includes an ...

Article

Efficacy and safety of more intensive lowering of LDL cholesterol [1]

Bonovas, Stefanos; Nikolopoulos, Georgios K.; Sitaras, N. M. (2011)

Article

Evaluation of the prognostic role of centromere 17 gain and HER2/topoisomerase II alpha gene status and protein expression in patients with breast cancer treated with anthracycline-containing adjuvant chemotherapy: Pooled analysis of two Hellenic Cooperative Oncology Group (HeCOG) phase III trials

Fountzilas, George; Dafni, U.; Bobos, M.; Kotoula, V.; Batistatou, Anna; Xanthakis, I.; Papadimitriou, C.; Kostopoulos, I.; Koletsa, T.; Tsolaki, E.; Televantou, D.; Timotheadou, E.; Koutras, A. K.; Klouvas, G. D.; Samantas, E.; Pisanidis, N.; Karanikiotis, C.; Sfakianaki, I.; Pavlidis, Nicholas; Gogas, H.; Linardou, H.; Kalogeras, K. T.; Pectasides, Dimitrios; Dimopoulos, M. A. (2013)

Background: The HER2 gene has been established as a valid biological marker for the treatment of breast cancer patients with trastuzumab and probably other agents, such as paclitaxel and anthracyclines. The TOP2A gene has ...

Article

Major depressive disorder in breast cancer: A critical systematic review of pharmacological and psychotherapeutic clinical trials

Carvalho, A. F.; Hyphantis, T.; Sales, P. M. G.; Soeiro-de-Souza, M. G.; Macêdo, D. S.; Cha, D. S.; McIntyre, R. S.; Pavlidis, Nicholas (2014)

Background: While women with breast cancer often face varying levels of psychological distress, there is a subgroup whose symptomatology reaches a threshold for diagnosis of major depressive disorder (MDD). Major depressive ...

Article

On the criteria used for assessing the risk of bias in randomized trials included in systematic reviews and meta-analyses addressing adverse effects

Bonovas, Stefanos; Lytras, Theodoros; Nikolopoulos, Georgios K. (2015)

Article

Prognostic significance of RACGAP1 mRNA expression in high-risk early breast cancer: A study in primary tumors of breast cancer patients participating in a randomized Hellenic Cooperative Oncology Group trial

Pliarchopoulou, K.; Kalogeras, K. T.; Kronenwett, R.; Wirtz, R. M.; Eleftheraki, A. G.; Batistatou, Anna; Bobos, M.; Soupos, N.; Polychronidou, G.; Gogas, H.; Samantas, E.; Christodoulou, C.; Makatsoris, T.; Pavlidis, Nicholas; Pectasides, Dimitrios; Fountzilas, George (2013)

Purpose: RACGAP1 is a Rac GTPase-activating protein involved in cell growth regulation, cell transformation and metastasis. The aim of the present study was to explore the prognostic and/or predictive significance of RACGAP1 ...

Article

Statins and the risk of colorectal cancer: An updated systematic review and meta-analysis of 40 studies

Lytras, Theodoros; Nikolopoulos, Georgios K.; Bonovas, Stefanos (2014)

Aim: To investigate the association between statin use and colorectal cancer risk, we conducted an updated meta-analysis of published studies. Methods: We performed a comprehensive search for studies published up to July ...

Article

Use of Fibrates and Cancer Risk: A Systematic Review and Meta-Analysis of 17 Long-Term Randomized Placebo-Controlled Trials

Bonovas, Stefanos; Nikolopoulos, Georgios K.; Bagos, Pantelis G. (2012)

Background: Fibrates comprise a class of well-established antilipidemic agents that significantly reduce cardiovascular events. Given the concerns of cancer with fibrate therapy, we undertook a systematic review and ...