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Browsing by Subject "Randomized controlled trial (topic)"

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    • Article  

      The beginning of personalized medicine in sepsis: Small steps to a bright future 

      Christaki, Eirini; Giamarellos-Bourboulis, Evangelos J. (2014)
      There is a growing recognition that there is a need for a more personalized approach towards sepsis care. In most clinical trials investigating novel therapeutic interventions against sepsis, patients have been considered ...

    • Article  

      The complex pathogenesis of bacteremia: From antimicrobial clearance mechanisms to the genetic background of the host 

      Christaki, Eirini; Giamarellos-Bourboulis, Evangelos J. (2014)
      Bacteremia develops when bacteria manage to escape the host immune mechanisms or when the otherwise well-orchestrated immune response fails to control bacterial spread due to inherent or acquired immune defects that are ...

    • Article  

      Developing the evidence base for cancer chemoprevention: Use of meta-analysis 

      Nikolopoulos, Georgios K.; Bagos, Pantelis G.; Bonovas, Stefanos (2011)
      Meta-analysis is a quantitative approach for systematically combining the results of previous studies in order to arrive at conclusions about the body of research. It answers a specific research question, includes an ...

    • Article  

      Efficacy and safety of more intensive lowering of LDL cholesterol [1] 

      Bonovas, Stefanos; Nikolopoulos, Georgios K.; Sitaras, N. M. (2011)

    • Article  

      Evaluation of the prognostic role of centromere 17 gain and HER2/topoisomerase II alpha gene status and protein expression in patients with breast cancer treated with anthracycline-containing adjuvant chemotherapy: Pooled analysis of two Hellenic Cooperative Oncology Group (HeCOG) phase III trials 

      Fountzilas, George; Dafni, U.; Bobos, M.; Kotoula, V.; Batistatou, Anna; Xanthakis, I.; Papadimitriou, C.; Kostopoulos, I.; Koletsa, T.; Tsolaki, E.; Televantou, D.; Timotheadou, E.; Koutras, A. K.; Klouvas, G. D.; Samantas, E.; Pisanidis, N.; Karanikiotis, C.; Sfakianaki, I.; Pavlidis, Nicholas; Gogas, H.; Linardou, H.; Kalogeras, K. T.; Pectasides, Dimitrios; Dimopoulos, M. A. (2013)
      Background: The HER2 gene has been established as a valid biological marker for the treatment of breast cancer patients with trastuzumab and probably other agents, such as paclitaxel and anthracyclines. The TOP2A gene has ...

    • Article  

      Major depressive disorder in breast cancer: A critical systematic review of pharmacological and psychotherapeutic clinical trials 

      Carvalho, A. F.; Hyphantis, T.; Sales, P. M. G.; Soeiro-de-Souza, M. G.; Macêdo, D. S.; Cha, D. S.; McIntyre, R. S.; Pavlidis, Nicholas (2014)
      Background: While women with breast cancer often face varying levels of psychological distress, there is a subgroup whose symptomatology reaches a threshold for diagnosis of major depressive disorder (MDD). Major depressive ...

    • Article  

      On the criteria used for assessing the risk of bias in randomized trials included in systematic reviews and meta-analyses addressing adverse effects 

      Bonovas, Stefanos; Lytras, Theodoros; Nikolopoulos, Georgios K. (2015)

    • Article  

      Prognostic significance of RACGAP1 mRNA expression in high-risk early breast cancer: A study in primary tumors of breast cancer patients participating in a randomized Hellenic Cooperative Oncology Group trial 

      Pliarchopoulou, K.; Kalogeras, K. T.; Kronenwett, R.; Wirtz, R. M.; Eleftheraki, A. G.; Batistatou, Anna; Bobos, M.; Soupos, N.; Polychronidou, G.; Gogas, H.; Samantas, E.; Christodoulou, C.; Makatsoris, T.; Pavlidis, Nicholas; Pectasides, Dimitrios; Fountzilas, George (2013)
      Purpose: RACGAP1 is a Rac GTPase-activating protein involved in cell growth regulation, cell transformation and metastasis. The aim of the present study was to explore the prognostic and/or predictive significance of RACGAP1 ...

    • Article  

      Statins and the risk of colorectal cancer: An updated systematic review and meta-analysis of 40 studies 

      Lytras, Theodoros; Nikolopoulos, Georgios K.; Bonovas, Stefanos (2014)
      Aim: To investigate the association between statin use and colorectal cancer risk, we conducted an updated meta-analysis of published studies. Methods: We performed a comprehensive search for studies published up to July ...

    • Article  

      Use of Fibrates and Cancer Risk: A Systematic Review and Meta-Analysis of 17 Long-Term Randomized Placebo-Controlled Trials 

      Bonovas, Stefanos; Nikolopoulos, Georgios K.; Bagos, Pantelis G. (2012)
      Background: Fibrates comprise a class of well-established antilipidemic agents that significantly reduce cardiovascular events. Given the concerns of cancer with fibrate therapy, we undertook a systematic review and ...

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