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Browsing by Subject "Stress"

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    • Article  

      Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels 

      Chauhan, V. P.; Martin, J. D.; Liu, H.; Lacorre, D. A.; Jain, S. R.; Kozin, S. V.; Stylianopoulos, T.; Mousa, A. S.; Han, X.; Adstamongkonkul, P.; Popovic, Z.; Huang, P.; Bawendi, M. G.; Boucher, Y.; Jain, R. K. (2013)
      Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...

    • Article  

      Anxiety, depression and defense mechanisms associated with treatment decisional preferences and quality of life in non-metastatic breast cancer: A 1-year prospective study 

      Hyphantis, T.; Almyroudi, A.; Paika, V.; Degner, L. F.; Carvalho, A. F.; Pavlidis, Nicholas (2013)
      Objective: Treatment decisional preferences impact breast cancer patients' health-related quality of life (HRQoL) and may relate to psychological variables, although many aspects of this relationship remain unknown. This ...

    • Article  

      Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors 

      Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Jain, S. R.; Diop-Frimpong, B.; Bardeesy, N.; Smith, B. L.; Ferrone, C. R.; Hornicek, F. J.; Boucher, Y.; Munn, L. L.; Jain, R. K. (2012)
      The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...

    • Article  

      Coevolution of solid stress and interstitial fluid pressure in tumors during progression: Implications for vascular collapse 

      Stylianopoulos, T.; Martin, J. D.; Snuderl, M.; Mpekris, F.; Jain, S. R.; Jain, R. K. (2013)
      The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or induced by the tumor itself due to its growth. Fluid pressure is ...

    • Article  

      Coping through avoidance may explain gender disparities in anxiety 

      Panayiotou, Georgia; Karekla, Maria; Leonidou, Chrysanthi (2017)
      To-date no models adequately address the higher vulnerability of women to anxiety pathology, in contrast to other disorders, such as depression where ruminative thinking has been identified as accounting for women's greater ...

    • Article  

      Depression in cancer: The many biobehavioral pathways driving tumor progression 

      Bortolato, B.; Hyphantis, T.; Valpione, S.; Perini, G.; Maes, M.; Morris, G.; Kubera, M.; Köhler, C. A.; Fernandes, B. S.; Stubbs, B.; Pavlidis, Nicholas; Carvalho, A. F. (2017)
      Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased ...

    • Article  

      Dispositional coping in individuals with anxiety disorder symptomatology: Avoidance predicts distress 

      Panayiotou, Georgia; Karekla, Maria; Mete, I. (2014)
      Anxiety disorders entail avoidance of feared situations and anxious experiences, which is believed to maintain anxiety pathology. It remains unclear if predominant coping styles, like avoidance, are similar across anxiety ...

    • Article  

      Does psychological distress vary between younger and older adults in health and disease? 

      Goulia, P.; Papadimitriou, I.; Machado, M. O.; Mantas, C.; Pappa, C.; Tsianos, Epameinondas; Pavlidis, Nicholas; Drosos, Alexandros A.; Carvalho, A. F.; Hyphantis, T. (2012)
      Objective: The effect of age on psychological distress remains controversial and it is unclear how a chronic medical illness influences this association. We aimed to compare the level of psychological distress between ...

    • Conference Object  

      Effects of stress on fricatives: Evidence from Standard Modern Greek 

      Themistocleous, Charalambos; Savva, Angelandria; Aristodemou, Andrie (International Speech and Communication Association, 2016)
      This study investigates the effects of stress on the spectral properties of fricative noise in Standard Modern Greek (SMG). Twenty female speakers of SMG participated in the study. Fricatives were produced in stressed and ...

    • Article  

      Factors affecting macrophage cytotoxic activity with particular emphasis on corticosteroids and acute stress 

      Schultz, R. M.; Chirigos, M. A.; Stoychkov, J. N.; Pavlidis, Nicholas (1979)

    • Article  

      Image-based biomechanics of collagen-based tissue equivalents 

      Barocas, V. Η; Sander, E.; Stylianopoulos, T.; Tranquillo, R. (2009)

    • Article  

      Multiscale modelling of solid tumour growth: the effect of collagen micromechanics 

      Wijeratne, P. A.; Vavourakis, V.; Hipwell, J. H.; Voutouri, C.; Papageorgis, P.; Stylianopoulos, T.; Evans, A.; Hawkes, D. J. (2016)
      Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. ...

    • Article  

      Multiscale, structure-based modeling for the elastic mechanical behavior of arterial walls 

      Barocas, V. Η; Stylianopoulos, T. (2007)
      Passive elastic behavior of arterial wall remains difficult to model. Although phenomenological and structural models exist, the question of how the three-dimensional network structure of the collagen in the artery determines ...

    • Article  

      Perceived social support helps, but does not buffer the negative impact of anxiety disorders on quality of life and perceived stress 

      Panayiotou, Georgia; Karekla, Maria (2013)
      Purpose: Anxiety disorders are prevalent and substantially hinder quality of life, in all domains, including social connections, mental and physical health. Past research on stress indicates that perceived social support ...

    • Article  

      Personality variables are associated with colorectal cancer patients' quality of life independent of psychological distress and disease severity 

      Paika, V.; Almyroudi, A.; Tomenson, B.; Creed, F.; Kampletsas, E. O.; Siafaka, V.; Gkika, S.; Mavreas, V.; Pavlidis, Nicholas; Hyphantis, T. (2010)
      Objective: The aim of the present study was to test whether psychological distress and personality variables are independently associated with health-related quality of life (HRQOL) in colorectal cancer patients, after ...

    • Article  

      Personality variables as predictors of early non-metastatic colorectal cancer patients' psychological distress and health-related quality of life: A one-year prospective study 

      Hyphantis, T.; Paika, V.; Almyroudi, A.; Kampletsas, E. O.; Pavlidis, Nicholas (2011)
      Objective: We aimed to assess the course of early non-metastatic colorectal cancer patients' psychological distress and health-related quality of life (HRQOL) and to identify relevant clinical and psychological predictors ...

    • Article  

      Psychiatric manifestations, personality traits and health-related quality of life in cancer of unknown primary site 

      Hyphantis, T.; Papadimitriou, I.; Petrakis, Dimitrios; Fountzilas, George; Repana, D.; Assimakopoulos, K.; Carvalho, A. F.; Pavlidis, Nicholas (2013)
      Objective Psychiatric manifestations and personality traits are known to influence cancer patients. We aimed to assess psychological distress symptoms, psychosocial factors and health-related quality of life (HRQoL) in ...

    • Article  

      Psychosocial predictors of health outcomes in colorectal cancer: A comprehensive review 

      Sales, P. M. G.; Carvalho, A. F.; McIntyre, R. S.; Pavlidis, Nicholas; Hyphantis, T. (2014)
      Background: A diagnosis of colorectal cancer (CRC) and its long-term treatment may lead to significant psychological distress and impaired health-related quality of life (HRQoL) for a significant proportion of patients. ...

    • Article  

      Remodeling of extracellular matrix due to solid stress accumulation during tumor growth 

      Pirentis, A. P.; Polydorou, C.; Papageorgis, P.; Voutouri, C.; Mpekris, F.; Stylianopoulos, T. (2015)
      Solid stresses emerge as the expanding tumor displaces and deforms the surrounding normal tissue, and also as a result of intratumoral component interplay. Among other things, solid stresses are known to induce extensive ...

    • Article  

      Role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors 

      Voutouri, C.; Mpekris, F.; Papageorgis, P.; Odysseos, A. D.; Stylianopoulos, T. (2014)
      Mechanical forces play a crucial role in tumor patho-physiology. Compression of cancer cells inhibits their proliferation rate, induces apoptosis and enhances their invasive and metastatic potential. Additionally, compression ...

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