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Browsing by Subject "Survival"

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    • Article  

      Advanced stage clear-cell epithelial ovarian cancer: The Hellenic cooperative oncology group experience 

      Pectasides, Dimitrios; Fountzilas, George; Aravantinos, Gerasimos; Kalofonos, H. P.; Efstathiou, E.; Farmakis, D.; Skarlos, Dimosthenis V.; Pavlidis, Nicholas; Economopoulos, T.; Dimopoulos, M. A. (2006)
      Purpose.: Ovarian clear-cell carcinomas (OCCC) are known to be possibly resistant to platinum-based chemotherapy and to have a poorer prognosis with respect to other subtypes of epithelial ovarian cancer (EOC). This study ...

    • Article  

      Cancer of unknown primary patients with midline nodal distribution: Midway between poor and favourable prognosis? 

      Pentheroudakis, George; Stoyianni, A.; Pavlidis, Nicholas (2011)
      Background: Midline nodal cancer of unknown primary (CUP) has varying definitions and an unclear natural history compared to that of extragonadal germ cell cancer (EGCC) and neuroendocrine tumors. Methods: We systematically ...

    • Article  

      Comparative survival with diverse chemotherapy regimens for cancer of unknown primary site: Multiple-treatments meta-analysis 

      Golfinopoulos, Vassilis; Pentheroudakis, George; Salanti, G.; Nearchou, A. D.; Ioannidis, J. P. A.; Pavlidis, Nicholas (2009)
      Objectives: To synthesize the evidence from randomized controlled trials concerning systemic treatment regimens for patients with cancer of unknown primary site (CUP). Data sources: PubMed and the Cochrane Library Central ...

    • Article  

      Effects of different chemotherapy regimens on survival for advanced cervical cancer: Systematic review and meta-analysis 

      Tzioras, S.; Pavlidis, Nicholas; Paraskevaidis, E.; Ioannidis, J. P. A. (2007)
      Background: A large number of trials have assessed various chemotherapy regimens for the treatment of advanced cervical cancer, but there is uncertainty about the magnitude of survival benefits. Methods: We searched (last ...

    • Article  

      Estrogen receptor β agonism increases survival in experimentally induced sepsis and ameliorates the genomic sepsis signature: A pharmacogenomic study 

      Christaki, Eirini; Opal, Steven M.; Jr, James C. Keith; Kessimian, Nubar; Palardy, J. E.; Parejo, N. A.; LaVallie, Edward R.; Racie, L.; Mounts, W.; Malamas, Michael S.; Mewshaw, Richard E.; Harris, Heather A.; Vlasuk, G. P. (2010)
      Background. Nonsteroidal agonists have been developed that selectively bind to and activate estrogen receptor β (ERβ) rather than estrogen receptor α (ERα). ERβ is expressed equally in both male and female mammals in ...

    • Article  

      Extraskeletal Ewing's sarcoma. Presentation of two cases and review of the literature 

      Pavlidis, Nicholas; Klouvas, G. D.; Kyparissiadis, P.; Sourla, A.; Papadimitriou, C. (1991)
      We present here two cases extraskeletal Ewing's sarcoma, the first in a 50-year-old female and the second in a 25-year-old male. We discuss the clinical picture, histopathology and therapeutic management. The literature ...

    • Article  

      Intensive chemotherapy with high-dose epirubicin every 2 weeks and prophylactic administration of filgrastim in advanced breast cancer 

      Fountzilas, George; Skarlos, Dimosthenis V.; Giannakakis, T.; Athanasiades, A.; Bafaloukos, Dimitrios; Kalogera-Fountzila, Anna; Bamia, C.; Pavlidis, Nicholas; Kosmidis, Paraskevas A. (1994)
      50 women with advanced breast cancer were treated with an intensified regimen which consisted of high-dose epirubicin (110 mg/m2) every 2 weeks and filgrastim (5 μg/kg) subcutaneously for 13 days, starting 24 h after ...

    • Article  

      Is the mortality rate for septic shock really decreasing? 

      Christaki, Eirini; Opal, Steven M. (2008)
      Survival rates for patients in septic shock have gradually improved in critical care units worldwide over the last 25 years. Further improvement will be predicated on the discovery of new therapies to disrupt the underlying ...

    • Article  

      Juvenile cancer: Improving care for adolescents and young adults within the frame of medical oncology 

      Pentheroudakis, George; Pavlidis, Nicholas (2005)
      Despite unique tumour epidemiology, a higher cancer incidence and modest survival improvement compared to paediatric patients, adolescents and young adults aged 15-30 have not been considered as a separate, 'special' group ...

    • Article  

      «Juvenile» oncology - A missing subspecialty. The experience of a reference cancer centre 

      Pentheroudakis, George; Mauri, D.; Kostadima, Lida; Golfinopoulos, Vassilis; Alexiou, G.; Karakatsanis, A.; Pavlidis, Nicholas (2006)
      Introduction: Despite unique tumor epidemiology and a higher cancer incidence compared to pediatric patients, adolescents and young adults have not been receiving specialized, multidisciplinary, centralized care. In an ...

    • Article  

      Levels of absolute survival benefit for systemic therapies of advanced cancer: A call for standards 

      Ioannidis, J. P. A.; Pavlidis, Nicholas (2003)
      Research on systemic interventions in patients with advanced stage malignancies should be systematised with an emphasis on the absolute gain in survival for the median patient. Such information is most meaningful with ...

    • Article  

      Liver metastases from cancer of unknown primary (CUPL): A retrospective analysis of presentation, management and prognosis in 49 patients and systematic review of the literature 

      Lazaridis, G.; Pentheroudakis, George; Fountzilas, George; Pavlidis, Nicholas (2008)
      Aim: Patients with liver metastases from cancer of unknown primary (CUPL) have a dismal prognosis. We retrospectively analysed their management and outcome and performed a systematic review of CUPL series published in the ...

    • Article  

      Long-term survivors among patients with cancer of unknown primary 

      Pavlidis, Nicholas; Petrakis, Dimitrios; Golfinopoulos, Vassilis; Pentheroudakis, George (2012)
      There is a general conception among oncologists that CUP patients behave poorly to treatment and carry a dismal survival. In this paper we are trying to elucidate the different groups of CUP patients and to describe in ...

    • Article  

      Malignant melanoma of unknown primary site. To make the long story short. A systematic review of the literature 

      Kamposioras, K.; Pentheroudakis, George; Pectasides, Dimitrios; Pavlidis, Nicholas (2011)
      Introduction: Although more than 90% of melanomas have a cutaneous origin, occasionally it is discovered as a secondary deposit without evident primary site. The aim of this study was to systematically review published ...

    • Book Chapter  

      Managing thoracic tumors during pregnancy 

      Pavlidis, Nicholas; Zarkavelis, George (Springer International Publishing, 2016)
      Thoracic tumors during pregnancy is a rare coexistence. Only 66 cases of lung cancer have been published during the last two decades. Gestational thymomas and mesotheliomas are even more infrequent gestational tumors. Among ...

    • Article  

      Metabolic syndrome and its components as predictors of all-cause mortality and coronary heart disease in type 2 diabetic patients 

      Protopsaltis, I. D.; Nikolopoulos, Georgios K.; Dimou, Eftihia; Brestas, Paris; Kokkoris, Stelios; Korantzopoulos, Panagiotis; Melidonis, Andreas (2007)
      Background: There is no consistent evidence regarding the prognostic value of metabolic syndrome (MS) in predicting all-cause mortality and coronary heart disease (CHD) risk among type 2 diabetic patients. We sought to ...

    • Article  

      Metastatic breast cancer with liver metastases: A registry analysis of clinicopathologic, management and outcome characteristics of 500 women 

      Pentheroudakis, George; Fountzilas, George; Bafaloukos, Dimitrios; Koutsoukou, V.; Pectasides, Dimitrios; Skarlos, Dimosthenis V.; Samantas, E.; Kalofonos, H. P.; Gogas, H.; Pavlidis, Nicholas (2006)
      Introduction. Breast cancer patients developing liver metastases have traditionally been considered to make up a poor prognosis group with median survival rates of less than 6 months. We retrospectively analysed clinicopathologic ...

    • Article  

      Metastatic breast carcinoma confined to bone: Portrait of a clinical entity 

      Briassoulis, E. Ch; Karavasilis, V.; Kostadima, Lida; Ignatiadis, M.; Fountzilas, George; Pavlidis, Nicholas (2004)
      BACKGROUND. The current study was performed to study metastatic breast carcinoma that remains confined to bone. METHODS. The medical notes of 2514 breast carcinoma patients who were treated in 2 academic units over a 20-year ...

    • Article  

      The missing kiss of life: Transcriptional activity of the metastasis suppressor gene KiSS1 in early breast cancer 

      Kostadima, Lida; Pentheroudakis, George; Pavlidis, Nicholas (2007)
      Background: KiSS-1 is a metastasis suppressor gene encoding a neuropeptide with potent antimetastatic activities in tumour cell lines. The transcriptional activity of the gene and its associations in resected breast cancer ...

    • Article  

      Molecular assignment of tissue of origin in cancer of unknown primary may not predict response to therapy or outcome: A systematic literature review 

      Pentheroudakis, George; Greco, F. A.; Pavlidis, Nicholas (2009)
      Background: Gene expression profiling platforms were recently shown to accurately assign cancer of unknown primary (CUP) to a primary tissue of origin, with unknown impact on patient outcome. We examined chemotherapy ...

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