• Doctoral Thesis  Open Access

      57Fe Mössbauer spectroscopic studies on β-thalassaemia using a mouse model for β-thalassaemia and red blood cell samples from patients 

      Charitou, Georgios H. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2019-05)
      Η β-θαλασσαιμία είναι μια κληρονομική αναιμία που προκαλείται από μεταλλάξεις του γονιδίου β‑σφαιρίνης. Επηρεάζει πολλαπλά όργανα και συνδέεται με σημαντική νοσηρότητα και θνησιμότητα. Σε αυτή την εργασία χρησιμοποιήθηκε ...
    • Article  

      Effect of pentoxifylline on treatment of lower limb ulcers in patients with thalassemia major 

      Angelides, N. S.; Angastiniotis, C.; Pavlidis, Nicholas (1992)
      The possible healing effect of deferoxamine and pentoxifylline on persisting lower limb ulcers was studied in 51 patients with thalassemia major. The results indicated that the regular use of deferoxamine at an intravenous ...
    • Article  

      Interactions of hydroxycarbamide (Hydroxyurea) with Iron and copper: Implications on toxicity and therapeutic strategies 

      Konstantinou, E.; Pashalidis, Ioannis; Kolnagou, A.; Kontoghiorghes, G. J. (2011)
      Presented at the 19th International Conference on Chelation, London, UK, 13-16 November 2009Preliminary spectrophotometric and potentiometric studies have shown that hydroxycarbamide or hydroxyurea (HU) can interact with ...
    • Doctoral Thesis  

      Screening for HbF inducing agents and evaluating the effect of metal ions on hydroxyurea's HbF inducing activity 

      Voskou, Stella M. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2019-12)
      Η β-θαλασσαιμία είναι μια αιμοσφαιρινοπάθεια που χαρακτηρίζεται από ελάχιστη έως καθόλου παραγωγή β-σφαιρίνης. Η φαρμακευτική επανεργοποίηση της εμβρυικής αιμοσφαιρίνης αποτελεί μια ελκυστική θεραπευτική προσέγγιση. Διάφοροι ...
    • Article  

      Survival of medically treated thalassemia patients in Cyprus. Trends and risk factors over the period 1980-2004 

      Telfer, Paul; Coen, Pietro G.; Christou, Soteroula; Hadjigavriel, Michael; Kolnakou, Anita; Pangalou, Evangelia; Pavlidis, Nicholas; Psiloines, Michael; Simamonian, Krikor; Skordos, Georghios; Sitarou, Maria; Angastiniotis, Michael (2006)
      BACKGROUND AND OBJECTIVES: A large number of patients with thalassemia major have been born and treated exclusively in Cyprus. They have been managed according to standard international practice, but few have been transplanted. ...