Browsing by Subject "Theoretical"

Article

Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model

Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (2013)

Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...

Article

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Jain, S. R.; Diop-Frimpong, B.; Bardeesy, N.; Smith, B. L.; Ferrone, C. R.; Hornicek, F. J.; Boucher, Y.; Munn, L. L.; Jain, R. K. (2012)

The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...

Article

In Vitro localized release of thermosensitive liposomes with ultrasound-induced hyperthermia

Mannaris, Christophoros; Efthymiou, Eleni; Meyre, Marie-Edith; AVERKIOU, MICHALAKIS A. (2013)

Article

Network characteristics of people who inject drugs within a new HIV epidemic following austerity in Athens, Greece

Tsang, M. A.; Schneider, J. A.; Sypsa, V.; Schumm, P.; Nikolopoulos, Georgios K.; Paraskeva, D.; Friedman, Samuel R.; Malliori-Minerva, Melpomeni; Hatzakis, A. (2015)

Background: Greece experienced an unprecedented increase in HIV cases among drug injectors in 2011 after economic crisis. Network-level factors are increasingly understood to drive HIV transmission in emerging epidemics. ...

Article

Remodeling of extracellular matrix due to solid stress accumulation during tumor growth

Pirentis, A. P.; Polydorou, C.; Papageorgis, P.; Voutouri, C.; Mpekris, F.; Stylianopoulos, T. (2015)

Solid stresses emerge as the expanding tumor displaces and deforms the surrounding normal tissue, and also as a result of intratumoral component interplay. Among other things, solid stresses are known to induce extensive ...

Article

The role of mechanical forces in tumor growth and therapy

Jain, R. K.; Martin, J. D.; Stylianopoulos, T. (2014)

Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...

Article

Role of vascular normalization in benefit from metronomic chemotherapy

Mpekris, F.; Baish, J. W.; Stylianopoulos, T.; Jain, R. K. (2017)

Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in ...

Article

Second-harmonic generation in a sound beam reflected and transmitted at a curved interface

Makin, I. R.; AVERKIOU, MICHALAKIS A.; Hamilton, M. F. (2000)

This article presents a model for second-harmonic generation in a sound beam that is reflected from or transmitted through a curved interface. Propagation in homogeneous fluids is assumed. Simple analytic solutions are ...

Article

Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes.

Stylianopoulos, T.; Kokonou, M.; Michael, S.; Tryfonos, A.; Rebholz, Claus; Odysseos, A. D.; Doumanidis, C. C. (2012)

The mechanical properties and hydraulic permeabilities of biomaterial scaffolds play a crucial role in their efficacy as tissue engineering platforms, separation processors, and drug delivery vehicles. In this study, ...

Article

Unemployment consequences of an aging population: An application of insider-outsider theory

Pissarides, Christopher A. (1989)