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Browsing by Subject "Theoretical"

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    • Article  

      Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model 

      Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (2013)
      Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...

    • Article  

      Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors 

      Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Jain, S. R.; Diop-Frimpong, B.; Bardeesy, N.; Smith, B. L.; Ferrone, C. R.; Hornicek, F. J.; Boucher, Y.; Munn, L. L.; Jain, R. K. (2012)
      The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...

    • Article  

      In Vitro localized release of thermosensitive liposomes with ultrasound-induced hyperthermia 

      Mannaris, Christophoros; Efthymiou, Eleni; Meyre, Marie-Edith; AVERKIOU, MICHALAKIS A. (2013)

    • Article  

      Network characteristics of people who inject drugs within a new HIV epidemic following austerity in Athens, Greece 

      Tsang, M. A.; Schneider, J. A.; Sypsa, V.; Schumm, P.; Nikolopoulos, Georgios K.; Paraskeva, D.; Friedman, Samuel R.; Malliori-Minerva, Melpomeni; Hatzakis, A. (2015)
      Background: Greece experienced an unprecedented increase in HIV cases among drug injectors in 2011 after economic crisis. Network-level factors are increasingly understood to drive HIV transmission in emerging epidemics. ...

    • Article  

      Remodeling of extracellular matrix due to solid stress accumulation during tumor growth 

      Pirentis, A. P.; Polydorou, C.; Papageorgis, P.; Voutouri, C.; Mpekris, F.; Stylianopoulos, T. (2015)
      Solid stresses emerge as the expanding tumor displaces and deforms the surrounding normal tissue, and also as a result of intratumoral component interplay. Among other things, solid stresses are known to induce extensive ...

    • Article  

      The role of mechanical forces in tumor growth and therapy 

      Jain, R. K.; Martin, J. D.; Stylianopoulos, T. (2014)
      Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, ...

    • Article  

      Role of vascular normalization in benefit from metronomic chemotherapy 

      Mpekris, F.; Baish, J. W.; Stylianopoulos, T.; Jain, R. K. (2017)
      Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in ...

    • Article  

      Second-harmonic generation in a sound beam reflected and transmitted at a curved interface 

      Makin, I. R.; AVERKIOU, MICHALAKIS A.; Hamilton, M. F. (2000)
      This article presents a model for second-harmonic generation in a sound beam that is reflected from or transmitted through a curved interface. Propagation in homogeneous fluids is assumed. Simple analytic solutions are ...

    • Article  

      Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes. 

      Stylianopoulos, T.; Kokonou, M.; Michael, S.; Tryfonos, A.; Rebholz, Claus; Odysseos, A. D.; Doumanidis, C. C. (2012)
      The mechanical properties and hydraulic permeabilities of biomaterial scaffolds play a crucial role in their efficacy as tissue engineering platforms, separation processors, and drug delivery vehicles. In this study, ...

    • Article  

      Unemployment consequences of an aging population: An application of insider-outsider theory 

      Pissarides, Christopher A. (1989)

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