Browsing by Subject "Thiophenes"

Now showing items 1-3 of 3

    • Article  

      3,5-bis(4-dodecylthiophen-2-yl)-4H-1,2,6-thiadiazin-4-one 

      Ioannidou, Heraklidia A.; Koutentis, Panayiotis Andreas (2012)
      3,5-Dichloro-4H-1,2,6-thiadiazin-4-one 1 reacts with (4-dodecylthiophen-2-yl)trimethylstannane 4 (2.2 equiv.) and Pd(Ph 3P) 2Cl 2 (5 mol%) in acetonitrile at ca. 82 °C to give 3,5-bis(4-dodecylthiophen-2-yl)-4H-1,2,6-thi ...
    • Article  

      3-Chloro-5-(4-dodecylthiophen-2-yl)-4H-1,2,6-thiadiazin-4-one 

      Ioannidou, Heraklidia A.; Koutentis, Panayiotis Andreas (2012)
      3-Chloro-5-trifluoromethanesulfonate-4H-1,2,6-thiadiazin-4-one 3 reacts with (4-dodecylthiophen-2-yl)trimethylstannane 5 (1 equiv.) in the presence of Pd(Ph 3P) 2Cl 2 (5 mol%) in benzene at ca. 20 °C for 5 h to give ...
    • Article  

      Predictive QSAR workflow for the in silico identification and screening of novel HDAC inhibitors 

      Melagraki, G.; Afantitis, Antreas; Sarimveis, H.; Koutentis, Panayiotis Andreas; Kollias, G.; Igglessi-Markopoulou, O. (2009)
      A linear Quantitative Structure-Activity Relationship (QSAR) is developed in this work for modeling and predicting HDAC inhibition by 5-pyridin-2-yl- thiophene-2-hydroxamic acids. In particular, a five-variable model is ...