• Article  

      Biphasic modeling of brain tumor biomechanics and response to radiation treatment 

      Angeli, S.; Stylianopoulos, T. (2016)
      Biomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical ...
    • Article  

      Classification capacity of a modular neural network implementing neurally inspired architecture and training rules 

      Poirazi, Panayiota; Neocleous, Costas K.; Pattichis, Constantinos S.; Schizas, Christos N. (2004)
      A three-layer neural network (NN) with novel adaptive architecture has been developed. The hidden layer of the network consists of slabs of single neuron models, where neurons within a slab-but not between slabs- have the ...
    • Article  

      Computational predictions of the tensile properties of electrospun fibre meshes: Effect of fibre diameter and fibre orientation 

      Barocas, V. Η; Stylianopoulos, T.; Bashur, C. A.; Goldstein, A. S.; Guelcher, S. A. (2008)
      The mechanical properties of biomaterial scaffolds are crucial for their efficacy in tissue engineering and regenerative medicine. At the microscopic scale, the scaffold must be sufficiently rigid to support cell adhesion, ...
    • Article  

      Experimental measurements and mathematical modeling towards quantification of brain swelling stress 

      Angeli, S.; Stylianopoulos, T. (2017)
      Traumatic brain injury results in brain tissue swelling which can be a life threatening condition due to skull confinement. While previous efforts successfully measured the exhibited volume change in brain tissue swelling, ...
    • Conference Object  

      Haemostasis in minimal invasive gynaecological surgery energies: Technical aspects, safety and efficacy 

      Tanos, Vasilios; Neofytou, Marios S.; Pattichis, Constantinos S. (Springer Verlag, 2016)
      The objective of this article is to examine the options, the effectiveness and the safety of the energies used in gynaecological minimal invasive surgery (MIGS), laparoscopic surgery developed in the end of 20th century. ...
    • Article  

      MRI-based morphological modeling, synthesis and characterization of cardiac tissue-mimicking materials 

      Kossivas, Fotis; Angeli, Stelios I.; Kafouris, Demetris; Patrickios, Costas S.; Tzagarakis, V.; Constantinides, Christakis (2012)
      This study uses standard synthetic methodologies to produce tissue-mimicking materials that match the morphology and emulate the in vivo murine and human cardiac mechanical and imaging characteristics, with dynamic mechanical ...
    • Conference Object  

      Multi-scale AM-FM motion analysis of ultrasound videos of carotid artery plaques 

      Murillo, S.; Murray, V.; Loizou, Christos P.; Pattichis, Constantinos S.; Pattichis, Marios S.; Barriga, E. S. (2012)
      An estimated 82 million American adults have one or more type of cardiovascular diseases (CVD). CVD is the leading cause of death (1 of every 3 deaths) in the United States. When considered separately from other CVDs, ...
    • Article  

      Multiscale computation for bioartificial soft tissues with complex geometries 

      Barocas, V. Η; Luo, X.-J.; Stylianopoulos, T.; Shephard, M. S. (2009)
      The mechanical function of soft collagenous tissues is inherently multiscale, with the tissue dimension being in the centimeter length scale and the underlying collagen network being in the micrometer length scale. This ...
    • Article  

      Regional elastic modulus measurements of the ex-vivo murine heart using atomic force microscopy 

      Kossivas, F.; Cao, L.; Michaelides, M.; Kyprianou, Andreas; Constantinides, C. (2013)
      Stiffness is an important mechanical index for characterisation of human and animal cells, tissues and intact organs. This study presents efforts for passive mechanical characterisation of the ex-vivo C57BL/6 murine heart ...
    • Conference Object  

      A simplified 2D real time navigation system for hysteroscopy imaging 

      Herakleous, I.; Constantinos, I. P.; Michael, E.; Neofytou, Marios S.; Pattichis, Constantinos S.; Tanos, Vasilios (2011)
      In this paper, a simplified 2D navigation system for hysteroscopy imaging was introduced. This system was evaluated in virtual endometrium models, and the position sensor measurement errors were very small and acceptable ...
    • Article  

      Snakes based segmentation of the common carotid artery intima media 

      Loizou, Christos P.; Pattichis, Constantinos S.; Pantzaris, Marios C.; Tyllis, Theodosis K.; Nicolaïdes, Andrew N. (2007)
      Ultrasound measurements of the human carotid artery walls are conventionally obtained by manually tracing interfaces between tissue layers. In this study we present a snakes segmentation technique for detecting the ...
    • Article  

      The Solid Mechanics of Cancer and Strategies for Improved Therapy 

      Stylianopoulos, T. (2017)
      Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...
    • Article  

      A standardised protocol for texture feature analysis of endoscopic images in gynaecological cancer 

      Neofytou, Marios S.; Tanos, Vasilios; Pattichis, Marios S.; Pattichis, Constantinos S.; Kyriacou, Efthyvoulos C.; Koutsouris, Demetrios Dionysios (2007)
      Background: In the development of tissue classification methods, classifiers rely on significant differences between texture features extracted from normal and abnormal regions. Yet, significant differences can arise due ...
    • Conference Object  

      Texture analysis of the endometrium during hysteroscopy: Preliminary results 

      Neophytou, Michael S.; Pattichis, Constantinos S.; Pattichis, Marios S.; Tanos, Vasilios; Kyriacou, Efthyvoulos C.; Pavlopoulos, Sotirios A.; Koutsouris, Demetrios Dionysios (2004)
      The objective of this study is to investigate the usefulness of texture analysis in the endometrium during hysteroscopy in endoscopic imaging of the uterine cavity. Endoscopy images from the endometrium from three subjects, ...
    • Conference Object  

      Uniaxial and biaxial mechanical behavior of human amnion 

      Barocas, V. Η; Oyen, M. L.; Stylianopoulos, T.; Calvin, S. E.; Cook, R. F. (Affiliation: Department of Biophysical Sciences and Medical Physics, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Minnesota Perinatal Physicians/Allina Health System, Minneapolis, MN 55407, United StatesCorrespondence Address: Oyen, M.L.Department of Biophysical Sciences and Medical Physics, University of Minnesota, Minneapolis, MN 55455, United States, 2005)
      Chorioamnion, the membrane surrounding a fetus during gestation (the "amniotic sac"), is a structural soft tissue for which the mechanical behavior is poorly understood-despite its critical role in maintaining a successful ...
    • Article  

      Uniaxial and biaxial mechanical behavior of human amnion 

      Barocas, V. Η; Oyen, M. L.; Cook, R. F.; Stylianopoulos, T.; Calvin, S. E.; Landers, D. V. (2005)
      Chorioamnion, the membrane surrounding a fetus during gestation, is a structural soft tissue critical for maintaining a successful pregnancy and delivery. However, the mechanical behavior of this tissue membrane is poorly ...
    • Article  

      Water solubility, antioxidant activity and cytochrome C binding of four families of exohedral adducts of C60 and C70 

      Witte, P.; Beuerle, F.; Hartnagel, U.; Lebovitz, R.; Savouchkina, A.; Sali, S.; Guldi, D.; Chronakis, Nikos; Hirsch, A. (2007)
      Over the past decade, surface-modified, water soluble fullerenes have been shown by many different investigators to exhibit strong antioxidant activity against reactive oxygen species (ROS) in vitro and to protect cells ...