• Article  

      Biphasic modeling of brain tumor biomechanics and response to radiation treatment 

      Angeli, S.; Stylianopoulos, T. (2016)
      Biomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical ...
    • Article  

      Computational predictions of the tensile properties of electrospun fibre meshes: Effect of fibre diameter and fibre orientation 

      Barocas, V. Η; Stylianopoulos, T.; Bashur, C. A.; Goldstein, A. S.; Guelcher, S. A. (2008)
      The mechanical properties of biomaterial scaffolds are crucial for their efficacy in tissue engineering and regenerative medicine. At the microscopic scale, the scaffold must be sufficiently rigid to support cell adhesion, ...
    • Article  

      Experimental measurements and mathematical modeling towards quantification of brain swelling stress 

      Angeli, S.; Stylianopoulos, T. (2017)
      Traumatic brain injury results in brain tissue swelling which can be a life threatening condition due to skull confinement. While previous efforts successfully measured the exhibited volume change in brain tissue swelling, ...
    • Article  

      Multiscale computation for bioartificial soft tissues with complex geometries 

      Barocas, V. Η; Luo, X.-J.; Stylianopoulos, T.; Shephard, M. S. (2009)
      The mechanical function of soft collagenous tissues is inherently multiscale, with the tissue dimension being in the centimeter length scale and the underlying collagen network being in the micrometer length scale. This ...
    • Article  

      Regional elastic modulus measurements of the ex-vivo murine heart using atomic force microscopy 

      Kossivas, F.; Cao, L.; Michaelides, M.; Kyprianou, Andreas; Constantinides, C. (2013)
      Stiffness is an important mechanical index for characterisation of human and animal cells, tissues and intact organs. This study presents efforts for passive mechanical characterisation of the ex-vivo C57BL/6 murine heart ...
    • Article  

      The Solid Mechanics of Cancer and Strategies for Improved Therapy 

      Stylianopoulos, T. (2017)
      Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...
    • Conference Object  

      Uniaxial and biaxial mechanical behavior of human amnion 

      Barocas, V. Η; Oyen, M. L.; Stylianopoulos, T.; Calvin, S. E.; Cook, R. F. (Affiliation: Department of Biophysical Sciences and Medical Physics, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Minnesota Perinatal Physicians/Allina Health System, Minneapolis, MN 55407, United StatesCorrespondence Address: Oyen, M.L.Department of Biophysical Sciences and Medical Physics, University of Minnesota, Minneapolis, MN 55455, United States, 2005)
      Chorioamnion, the membrane surrounding a fetus during gestation (the "amniotic sac"), is a structural soft tissue for which the mechanical behavior is poorly understood-despite its critical role in maintaining a successful ...
    • Article  

      Uniaxial and biaxial mechanical behavior of human amnion 

      Barocas, V. Η; Oyen, M. L.; Cook, R. F.; Stylianopoulos, T.; Calvin, S. E.; Landers, D. V. (2005)
      Chorioamnion, the membrane surrounding a fetus during gestation, is a structural soft tissue critical for maintaining a successful pregnancy and delivery. However, the mechanical behavior of this tissue membrane is poorly ...