Browsing by Subject "Topotecan"

Article

Effects of different chemotherapy regimens on survival for advanced cervical cancer: Systematic review and meta-analysis

Tzioras, S.; Pavlidis, Nicholas; Paraskevaidis, E.; Ioannidis, J. P. A. (2007)

Background: A large number of trials have assessed various chemotherapy regimens for the treatment of advanced cervical cancer, but there is uncertainty about the magnitude of survival benefits. Methods: We searched (last ...

Article

Management of leptomeningeal malignancy

Pentheroudakis, George; Pavlidis, Nicholas (2005)

Leptomeningeal carcinomatosis is defined as malignant infiltration of the pia matter and arachnoid membrane. Leukaemias and lymphomas, lung, breast cancer and melanoma are the primary tumours commonly associated with ...

Article

Management of patients with recurrent/advanced cervical cancer beyond first line platinum regimens: Where do we stand? A literature review

Boussios, Stergios; Seraj, E.; Zarkavelis, George; Petrakis, Dimitrios; Kollas, Aristomenes; Kafantari, Aikaterini; Assi, A.; Tatsi, K.; Pavlidis, Nicholas; Pentheroudakis, George (2016)

Background Cervical cancer is the fourth most common cancer affecting women worldwide. Despite advances in screening and human papillomavirus (HPV) vaccination, a significant number of women present with or develop advanced ...

Article

Phase I trial of intravenous cisplatin-topotecan chemotherapy for three consecutive days in patients with advanced solid tumors: Parallel topotecan escalation in two fixed platinum dosing schemes

Pentheroudakis, George; Briassoulis, E. Ch; Karavasilis, V.; Mauri, D.; Tzamakou, E.; Rammou, D.; Pavlidis, Nicholas (2005)

Purpose: We performed a phase I study of two fixed dosing schemes of cisplatin, a DNA cross-linker, with intravenous escalating topotecan, a DNA-topoisomerase I inhibitor. Experimental Design: 40 patients with advanced ...

Article

Phase II study of docetaxel-vinorelbine in platinum-resistant, paclitaxel-pretreated ovarian cancer

Aravantinos, Gerasimos; Bafaloukos, Dimitrios; Fountzilas, George; Christodoulou, C.; Papadimitriou, C.; Pavlidis, Nicholas; Kalofonos, H. P.; Gogas, H.; Kosmidis, Paraskevas A.; Dimopoulos, M. A. (2003)

Background: This multicenter, prospective phase II study evaluated the safety and efficacy of the combination of docetaxel and vinorelbine in patients with platinum-resistant, paclitaxel-pretreated recurrent ovarian cancer. ...

Article

Survival benefits with diverse chemotherapy regimens for ovarian cancer: Meta-analysis of multiple treatments

Kyrgiou, M.; Salanti, G.; Pavlidis, Nicholas; Paraskevaidis, E.; Ioannidis, J. P. A. (2006)

Background: Numerous randomized trials have compared different chemotherapy regimens in women with ovarian cancer. Although ovarian cancer survival has improved in recent years, the magnitude of these incremental benefits ...

Article

Treatment for Patients With Unknown Primary Carcinoma and Unfavorable Prognostic Factors

Greco, F. A.; Pavlidis, Nicholas (2009)

The treatment for patients with unknown primary carcinoma, particularly those with unfavorable prognosis factors, has changed in the last decade, and continues to evolve. Empiric chemotherapy trials reported since 2000 ...