• Article  

      Advanced soft-tissue sarcoma and treatment options: Critical appraisal of trabectedin 

      Desar, Ingrid M. E.; Constantinidou, Anastasia; Kaal, Suzanne E. J.; Jones, Robin Lewis; Graaf, W. T. A. van der (2016)
      Soft-tissue sarcomas (STS) are a heterogeneous group of rare solid tumors of mesenchymal origin. This paper reviews the current status of systemic treatment in advanced and metastatic soft tissue sarcomas, with an emphasis ...
    • Article  

      The evolution of systemic therapy in sarcoma 

      Constantinidou, Anastasia; Pollack, S. M.; Loggers, Elizabeth; Rodler, E.; Jones, Robin Lewis (2013)
      Approximately 50% of patients with localized soft tissue sarcomas will develop recurrent disease after complete surgical resection, requiring alternative means of treatment. Conventional chemotherapy comprising of doxorubicin ...
    • Article  

      Trabectedin in advanced synovial sarcomas: A multicenter retrospective study from four European institutions and the Italian Rare Cancer Network 

      Sanfilippo, R.; Dileo, Palma; Blay, Jean-Yves; Constantinidou, Anastasia; Cesne, Axel Le; Benson, Charlotte; Vizzini, L.; Contu, Marianna; Baldi, Giacomo G.; P, Angelo Dei Tos; Casali, Paolo G. (2015)
      Treatment options for patients with metastatic synovial sarcoma are limited. Over recent years, trabectedin has emerged as an effective agent for patients with advanced soft tissue sarcomas resistant to anthracyclines and ...
    • Article  

      Trabectedin-related rhabdomyolysis: An uncommon but fatal toxicity 

      Stoyianni, A.; Kapodistrias, N.; Kampletsas, E. O.; Pentheroudakis, George; Pavlidis, Nicholas (2011)
      Rhabdomyolysis is defined as the dissolution of striped muscle characterized by the leakage of intracellular muscle components into the circulation, which can ultimately lead to renal failure with a possible fatal outcome. ...