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Browsing by Subject "Transcription, Genetic"

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    • Article  

      Genomic approaches that aid in the identification of transcription factor target genes 

      Kirmizis, Antonis; Farnham, P. J. (2004)
      It is well-established that deregulation of the transcriptional activity of many different genes has been causatively linked to human diseases. In cancer, altered patterns of gene expression are often the result of the ...

    • Article  

      Histone H3 tail clipping regulates gene expression 

      Santos-Rosa, H.; Kirmizis, Antonis; Nelson, C.; Bartke, T.; Saksouk, N.; Cote, J.; Kouzarides, T. (2009)
      Induction of gene expression in yeast and human cells involves changes in the histone modifications associated with promoters. Here we identify a histone H3 endopeptidase activity in Saccharomyces cerevisiae that may ...

    • Article  

      Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy 

      Kirmizis, Antonis; Bartley, S. M.; Farnham, P. J. (2003)
      We have previously identified SU(Z)12 as an E2F target gene. Because many E2F target genes encode proteins that are critical for the control of cell proliferation, we have further characterized the regulation and expression ...

    • Article  

      Involvement of host DNA gyrase in growth of bacteriophage T5 

      Constantinou, Andreas I.; Voelkel-Meiman, K.; Sternglanz, R.; McCorquodale, M. M.; McCorquodale, D. J. (1986)
      Bacteriophage T5 did not grow at the nonpermissive temperature of 42°C in Escherichia coli carrying a temperature-sensitive mutation in gyrB [gyrB(Ts)], but it did grow in gyrA(Ts) mutants at 42°C. These findings indicate ...

    • Article  

      Overexpression of the m4 and mα genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition 

      Apidianakis, Yiorgos; Nagel, A. C.; Chalkiadaki, Angeliki; Preiss, A.; Delidakis, Christos (1999)
      Intercellular signalling mediated by Notch proteins is crucial to many cell fate decisions in metazoans. Its profound effects on cell fate and proliferation require that a complex set of responses involving positive and ...

    • Article  

      Refinement of the gene locus for autosomal dominant medullary cystic kidney disease type 1 (MCKD1) and construction of a physical and partial transcriptional map of the region 

      Rüschendorf, F.; Fuchshuber, A.; Kroiss, S.; Karle, S.; Berthold, S.; Huck, K.; Burton, C.; Rahman, N.; Koptides, Michael; Constantinou-Deltas, Constantinos D.; Otto, E.; Feest, T.; Hildebrandt, F. (2001)
      Autosomal dominant medullary cystic kidney disease (MCKD) is an adult onset tubulointerstitial nephropathy that leads to salt wasting and end-stage renal failure. A gene locus (MCKD1) has been mapped on chromosome 1q21. ...

    • Article  

      Regulation of Lactate Dehydrogenase Gene Expression by AMP‐dependent Protein Kinase Subunits 

      JUNGMANN, R. A.; Constantinou, Andreas I.; SQUINTO, S. P.; KWAST‐WELFELD, J.; SCHWEPPE, J. S. (1986)

    • Article  

      Regulation of retinoid X receptor-γ gene transcript levels in rat heart cells 

      Georgiades, Pantelis; Brickell, P. M. (1998)
      Retinoid X receptor-γ (RXRγ) is a transcription factor that mediates retinoid signalling and is expressed in rat heart during adult life. However, its expression in embryonic and neonatal heart has not been investigated ...

    • Article  

      Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells 

      Tonetti, D. A.; Rubenstein, R.; DeLeon, M.; Zhao, H.; Pappas, S. G.; Bentrem, D. J.; Chen, B.; Constantinou, Andreas I.; Jordan, V. C. (2003)
      We previously reported stable transfection of estrogen receptor alpha (ERα) into the ER-negative MDA-MB-231 cells (S30) as a tool to examine the mechanism of action of estrogen and antiestrogens [J. Natl. Cancer Inst. 84 ...

    • Article  

      Viral correlates of HIV-1 disease 

      Anastassopoulou, C. G.; Kostrikis, Leontios G. (2005)
      The transmission of HIV and the progression of HIV disease are influenced not only by a large number of human host factors, but also by certain correlates of the ever fluctuating virus quasispecies. The present review ...

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