Browsing by Subject "Transcription, Genetic"

Article

Genomic approaches that aid in the identification of transcription factor target genes

Kirmizis, Antonis; Farnham, P. J. (2004)

It is well-established that deregulation of the transcriptional activity of many different genes has been causatively linked to human diseases. In cancer, altered patterns of gene expression are often the result of the ...

Article

Histone H3 tail clipping regulates gene expression

Santos-Rosa, H.; Kirmizis, Antonis; Nelson, C.; Bartke, T.; Saksouk, N.; Cote, J.; Kouzarides, T. (2009)

Induction of gene expression in yeast and human cells involves changes in the histone modifications associated with promoters. Here we identify a histone H3 endopeptidase activity in Saccharomyces cerevisiae that may ...

Article

Identification of the polycomb group protein SU(Z)12 as a potential molecular target for human cancer therapy

Kirmizis, Antonis; Bartley, S. M.; Farnham, P. J. (2003)

We have previously identified SU(Z)12 as an E2F target gene. Because many E2F target genes encode proteins that are critical for the control of cell proliferation, we have further characterized the regulation and expression ...

Article

Involvement of host DNA gyrase in growth of bacteriophage T5

Constantinou, Andreas I.; Voelkel-Meiman, K.; Sternglanz, R.; McCorquodale, M. M.; McCorquodale, D. J. (1986)

Bacteriophage T5 did not grow at the nonpermissive temperature of 42°C in Escherichia coli carrying a temperature-sensitive mutation in gyrB [gyrB(Ts)], but it did grow in gyrA(Ts) mutants at 42°C. These findings indicate ...

Article

Overexpression of the m4 and mα genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition

Apidianakis, Yiorgos; Nagel, A. C.; Chalkiadaki, Angeliki; Preiss, A.; Delidakis, Christos (1999)

Intercellular signalling mediated by Notch proteins is crucial to many cell fate decisions in metazoans. Its profound effects on cell fate and proliferation require that a complex set of responses involving positive and ...

Article

Refinement of the gene locus for autosomal dominant medullary cystic kidney disease type 1 (MCKD1) and construction of a physical and partial transcriptional map of the region

Rüschendorf, F.; Fuchshuber, A.; Kroiss, S.; Karle, S.; Berthold, S.; Huck, K.; Burton, C.; Rahman, N.; Koptides, Michael; Constantinou-Deltas, Constantinos D.; Otto, E.; Feest, T.; Hildebrandt, F. (2001)

Autosomal dominant medullary cystic kidney disease (MCKD) is an adult onset tubulointerstitial nephropathy that leads to salt wasting and end-stage renal failure. A gene locus (MCKD1) has been mapped on chromosome 1q21. ...

Article

Regulation of Lactate Dehydrogenase Gene Expression by AMP‐dependent Protein Kinase Subunits

JUNGMANN, R. A.; Constantinou, Andreas I.; SQUINTO, S. P.; KWAST‐WELFELD, J.; SCHWEPPE, J. S. (1986)

Article

Regulation of retinoid X receptor-γ gene transcript levels in rat heart cells

Georgiades, Pantelis; Brickell, P. M. (1998)

Retinoid X receptor-γ (RXRγ) is a transcription factor that mediates retinoid signalling and is expressed in rat heart during adult life. However, its expression in embryonic and neonatal heart has not been investigated ...

Article

Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells

Tonetti, D. A.; Rubenstein, R.; DeLeon, M.; Zhao, H.; Pappas, S. G.; Bentrem, D. J.; Chen, B.; Constantinou, Andreas I.; Jordan, V. C. (2003)

We previously reported stable transfection of estrogen receptor alpha (ERα) into the ER-negative MDA-MB-231 cells (S30) as a tool to examine the mechanism of action of estrogen and antiestrogens [J. Natl. Cancer Inst. 84 ...

Article

Viral correlates of HIV-1 disease

Anastassopoulou, C. G.; Kostrikis, Leontios G. (2005)

The transmission of HIV and the progression of HIV disease are influenced not only by a large number of human host factors, but also by certain correlates of the ever fluctuating virus quasispecies. The present review ...