Browsing by Subject "Transgenes"

Now showing items 1-3 of 3

Article

Direct conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes

Iacovides, D.; Rizki, G.; Lapathitis, Georgios; Strati, K. (2016)

The insufficient ability of specialized cells such as neurons, cardiac myocytes, and epidermal cells to regenerate after tissue damage poses a great challenge to treat devastating injuries and ailments. Recent studies ...
Article

Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes

Markstein, M.; Pitsouli, Chrysoula; Villalta, C.; Celniker, S. E.; Perrimon, N. (2008)

A major obstacle to creating precisely expressed transgenes lies in the epigenetic effects of the host chromatin that surrounds them. Here we present a strategy to overcome this problem, employing a Gal4-inducible luciferase ...
Article

vavCre transgenic mice: A tool for mutagenesis in hematopoietic and endothelial lineages

Georgiades, Pantelis; Ogilvy, S.; Duval, H.; Licence, D. R.; Charnock-Jones, D. S.; Smith, S. K.; Print, C. G. (2002)

Cre transgenic mice can be used to delete gene sequences flanked by loxP sites in specific somatic tissues. We have generated vavCre transgenic mice, which can be used to inactivate genes specifically in adult hematopoietic ...