Browsing by Subject "X ray crystallography"

Article

The 1.76 Å resolution crystal structure of glycogen phosphorylase b complexed with glucose, and CP320626, a potential antidiabetic drug

Oikonomakos, Nikos G.; Zographos, Spyros E.; Skamnaki, Vicky T.; Archontis, Georgios Z. (2002)

CP320626, a potential antidiabetic drug, inhibits glycogen phosphorylase in synergism with glucose. To elucidate the structural basis of synergistic inhibition, we determined the structure of muscle glycogen phosphorylase ...

Article

Amphiphilic single and double networks: a small-angle X-ray scattering investigation

Zhang, X. K.; Kyriakos, K.; Rikkou-Kalourkoti, Maria D.; Kitiri, E. N.; Patrickios, Costas S.; Papadakis, Christine M. (2016)

We investigated the microphase-separated morphologies of water-swollen amphiphilic single and double polymer networks using small-angle X-ray scattering (SAXS). The networks consist of (i) a first conetwork containing ...

Article

Correlations of synthetic, spectroscopic, structural, and speciation studies in the biologically relevant Cobalt(II) - Citrate system: The tale of the first aqueous dinuclear Cobalt(II) - Citrate complex

Kotsakis, N.; Raptopoulou, C. P.; Tangoulis, V.; Terzis, A.; Giapintzakis, John; Jakusch, T.; Kiss, T.; Salifoglou, A. (2003)

Synthetic efforts targeting soluble species of Co(II) with the low molecular mass physiological ligand citric acid led to the isolation of the first dinuclear complex [Co2(C6H5O7)2 (H2O)4]2-, at pH ∼5, in the form of its ...

Article

Crystallographic and computational studies on 4-phenyl-N-(β-D- glucopyranosyl)-1H-1,2, 3-triazole-1-acetamide, an inhibitor of glycogen phosphorylase: Comparison with α-D-glucose, N-acetyl-β-D- glucopyranosylamine and N-benzoyl-N′-β-D-glucopyranosyl urea binding

Alexacou, Kyra Melinda; Hayes, Joseph M.; Tiraidis, Costas; Zographos, Spyros E.; Leonidas, Demetres D.; Chrysina, Evangelia D.; Archontis, Georgios Z.; Oikonomakos, Nikos G.; Paul, J. V.; Varghese, B.; Loganathan, D. (2008)

4-Phenyl-N-(β-D-glucopyranosyl)-1H-1,2,3-triazole-1-acetamide (glucosyltriazolylacetamide) has been studied in kinetic and crystallographic experiments with glycogen phosphorylase b (GPb), in an effort to utilize its ...

Article

Employment of methyl 2-pyridyl ketone oxime in manganese non-carboxylate chemistry: MnII2MnIV and MnII 2MnIII6 complexes

Stoumpos, Constantinos C.; Stamatatos, Theocharis C.; Sartzi, H.; Roubeau, O.; Tasiopoulos, Anastasios J.; Nastopoulos, Vassilios; Teat, S. J.; Christou, George; Perlepes, Spyros P. (2009)

The employment of the anion of methyl 2-pyridyl ketone oxime (mpko -) as a tridentate chelating/bridging ligand in manganese chemistry is described. The inorganic anion (Br-, ClO4-) used in the reaction affects the identity ...

Article

Glucose-based spiro-isoxazolines: A new family of potent glycogen phosphorylase inhibitors

Benltifa, Mahmoud; Hayes, Joseph M.; Vidal, Sébastien; Gueyrard, David; Goekjian, Peter G.; Praly, Jean Pierre; Kizilis, Gregory; Tiraidis, Costas; Alexacou, Kyra Melinda; Chrysina, Evangelia D.; Zographos, Spyros E.; Leonidas, Demetres D.; Archontis, Georgios Z.; Oikonomakos, Nikos G. (2009)

A series of glucopyranosylidene-spiro-isoxazolines was prepared through regio- and stereoselective [3+2]-cycloaddition between the methylene acetylated exo-glucal and aromatic nitrile oxides. The deprotected cycloadducts ...

Article

High nuclearity single-molecule magnets: A mixed-valence Mn26 cluster containing the di-2-pyridylketone diolate dianion

Stamatatos, Theocharis C.; Nastopoulos, Vassilios; Tasiopoulos, Anastasios J.; Moushi, Eleni E.; Wernsdorfer, W.; Christou, George; Perlepes, Spyros P. (2008)

The employment of the dianion (dpkd2-) of the gem-diol form of di-2-pyridylketone (dpk) as a tetradentate chelate in manganese chemistry is reported, and the synthesis, crystal structure, and magnetochemical characterization ...

Article

HIV-1 integrase: From biology to chemotherapeutics

Zeinalipour-Loizidou, E.; Nicolaou, Charalambos P.; Nicolaïdes, Andrew N.; Kostrikis, Leontios G. (2007)

AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people are HIV-infected and new cases are being diagnosed every year. Despite the fact that HAART has moved AIDS from the category of ...

Article

HIV-1 integrase: From biology to chemotherapeuticsAAA

Zeinalipour-Loizidou, E.; Nicolaou, Charalambos P.; Nicolaïdes, Andrew N.; Kostrikis, Leontios G. (2007)

AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people are HIV-infected and new cases are being diagnosed every year. Despite the fact that HAART has moved AIDS from the category of ...

Article

Inducing single-molecule magnetism in a family of loop-of-loops aggregates: Heterometallic Mn40Na4 clusters and the homometallic Mn44 analogue

Moushi, Eleni E.; Lampropoulos, Christos; Wernsdorfer, W.; Nastopoulos, Vassilios; Christou, George; Tasiopoulos, Anastasios J. (2010)

The syntheses, crystal structures, and magnetic properties of a new family of heterometallic Mn40Na4 and homometallic Mn44 loop-of-loops aggregates are reported. The reactions of [Mn3O(O 2CMe)6(py)3]•py with 1,3-propanediol ...

Article

Insertion of functional groups into a Nd 3+ metal-organic framework via single-crystal-to-single-crystal coordinating solvent exchange

Manos, Manolis J.; Kyprianidou, Eleni J.; Papaefstathìou, Giannis S.; Tasiopoulos, Anastasios J. (2012)

Single-crystal-to-single-crystal (SCSC) transformations represent some of the most fascinating phenomena in chemistry. They are not only intriguing from a basic science point of view but also provide a means to modify or ...

Article

Investigation on uranyl interaction with bioactive ligands. Synthesis and structural studies of the uranyl complexes with glycine and N-(2-mercaptopropionyl)glycine

Keramidas, Anastasios D.; Rikkou, Maria P.; Drouza, Chryssoula; Raptopoulou, Catherine P.; Terzis, Aris; Pashalidis, Ioannis (2002)

Three new uranium(VI) compounds have been prepared with glycine (Hgly), N-(2-mercaptopropionyl)glycine (Hmpg) and 2,2′-dithiobis(N-propionylglycine) (tpg). The crystal structure of [UO2(Hgly)2Cl2] has been solved, revealing ...

Article

Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase

Watson, K. A.; Chrysina, Evangelia D.; Tsitsanou, K. E.; Zographos, Spyros E.; Archontis, Georgios Z.; Fleet, G. W. J.; Oikonomakos, Nikos G. (2005)

Glycogen phosphorylase (GP) is currently exploited as a target for inhibition of hepatic glycogenolysis under high glucose conditions. Spirohydantoin of glucopyranose and N-acetyl-β-D-glucopyranosylamine have been identified ...

Article

Manganese citrate chemistry: Syntheses, spectroscopic studies, and structural characterizations of novel mononuclear, water-soluble manganese citrate complexes

Matzapetakis, M.; Karligiano, N.; Bino, A.; Dakanali, M.; Raptopoulou, C. P.; Tangoulis, V.; Terzis, A.; Giapintzakis, John; Salifoglou, A. (2000)

The first two mononuclear manganese citrate complexes, (NH4)4[Mn(II)(C6H5O7)2] (1) and (NH4)5[Mn(III)(C6H4O7)2]·2H2O (2) were synthesized in aqueous solutions near physiological pH values. They were isolated in their pure ...

Article

Mixed transition metal-lanthanide complexes at high oxidation states: Heteronuclear CeIVMnIV clusters

Tasiopoulos, Anastasios J.; Milligan Jr., P. L.; Abboud, K. A.; O'Brien, T. A.; Christou, George (2007)

The syntheses of the first mixed-metal CeIVMnIV complexes are reported. [CeMn2O3(O2CMe)(NO 3)4(H2O)2(bpy)2]-(NO 3) (1

Article

A Mn15 single-molecule magnet consisting of a supertetrahedron incorporated in a loop

Moushi, Eleni E.; Masello, A.; Wernsdorfer, W.; Nastopoulos, Vassilios; Christou, George; Tasiopoulos, Anastasios J. (2010)

Two new Mn15 clusters consisting of a supertetrahedron which is incorporated in a loop are reported. The reactions of [Mn(O2CEt) 2]·2H2O with the diols 1,3-propanediol (H 2pd) or 2-methyl-1,3-propanediol (H2mpd) in the ...

Article

Model investigations for vanadium-protein interactions: Vanadium(III) compounds with dipeptides and their oxovanadium(IV) analogues

Tasiopoulos, Anastasios J.; Tolis, Evangelos I.; Tsangaris, John Michael; Evangelou, Angelos M.; Woollins, J. D.; Slawin, A. M. Z.; Pessoa, J. C.; Correia, I.; Kabanos, Themistoklis A. (2002)

The reaction of VCl3 with 1,10-phenanthroline and a series of dipeptides (H2dip), having aliphatic as well as aromatic side chains, in methyl alcohol and in the presence of triethylamine affords vanadium(III) compounds of ...

Article

Molecular Dynamics in Drug Design: New Generations of Compstatin Analogs

Tamamis, Phanourios; López de Victoria, A.; Gorham, R. D.; Bellows-Peterson, M. L.; Pierou, P.; Floudas, C. A.; Morikis, D.; Archontis, Georgios Z. (2012)

We report the computational and rational design of new generations of potential peptide-based inhibitors of the complement protein C3 from the compstatin family. The binding efficacy of the peptides is tested by extensive ...

Article

Molybdenum(VI) coordination chemistry of the N,N-disubstituted bis(hydroxylamido)-1,3,5-triazine ligand, H2bihyat. Water-assisted activation of the MoVI=O bond and reversible dimerization of cis-[MoVIO2(bihyat)] to [MoVI2O 4(bihyat)2(H2O)2]

Stylianou, Marios; Nikolakis, Vladimiros A.; Chilas, G. I.; Jakusch, T.; Vaimakis, T.; Kiss, Tamás; Sigalas, Michael P.; Keramidas, Anastasios D.; Kabanos, Themistoklis A. (2012)

Reaction of the N,N-disubstituted bis(hydroxylamino) ligand 2,6-bis[hydroxy(methyl)amino]-4-morpholino-1,3,5-triazine (H2bihyat) with cis-[MoVIO2(acac)2] in tetrahydrofuran resulted in isolation of the mononuclear compound ...

Article

Monolayers, bilayers and micelles of zwitterionic lipids as model systems for the study of specific anion effects

Aroti, Andria; Leontidis, Epameinondas; Dubois, M.; Zemb, T.; Brezesinski, G. (2007)

This work is a review of the effect of different monovalent anions (belonging to the Hofmeister series) on a single model amphiphile, phosphatidylcholine molecules in contact with water, in three different geometries, ...